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Establishing a three-generation prospective study: Bogalusa daughters

Part of: DOHaD on International Women's Day 2020

Published online by Cambridge University Press:  20 June 2019

EW Harville Open the ORCID record for EW Harville [Opens in a new window] ,
D Breckner ,
T Shu ,
M Cooper  and
LA Bazzano
EW Harville*
Affiliation:
Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA
D Breckner
Affiliation:
Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA
T Shu
Affiliation:
Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA
M Cooper
Affiliation:
Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA
LA Bazzano
Affiliation:
Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA
*
Address for correspondence: EW Harville, Department of Epidemiology, Tulane School of Public Health and Tropical Medicine, 1440 Canal St. Ste. 2001, #8318, New Orleans, LA 70112-2715; Tel. 504-988-7327; Fax. 504-988-1568. Email: [email protected]
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Abstract

Objective:

The Developmental Origins of Disease hypothesis has spurred increased interest in how prenatal exposures affect lifelong health, while mechanisms such as epigenetics may explain the multigenerational influences on health. Such factors are not well captured within conventional epidemiologic study designs. We explored the feasibility of collecting information on the offspring and grand-offspring of participants in a long-running study.

Design:

The Bogalusa Heart Study is a study, begun in 1973, of life-course cardiovascular health in a semirural population (65% white and 35% black).

Main measures:

Female participants who had previously provided information on their pregnancies were contacted to obtain contact information for their daughters aged 12 and older. Daughters were then contacted to obtain reproductive histories, and invited for a clinic or lab visit to measure cardiovascular risk factors.

Results:

Two hundred seventy-four daughters of 208 mothers were recruited; 81% (223) had a full clinic visit and 19% (51) a phone interview only. Forty-five percent of the daughters were black, and 55% white. Mean and median age at interview was 27, with 15% under the age of 18. The strongest predictors of participation were black race, recent maternal participation in the parent study, and living in or near Bogalusa. Simple correlations for cardiovascular risk factors across generations were between r = 0.19 (systolic blood pressure) and r = 0.39 (BMI, LDL).

Conclusion:

It is feasible to contact the children of study participants even when participants are adults, and initial information on the grandchildren can also be determined in this manner.

Keywords

Transgenerationaldevelopmental origins of health and diseasemethodsepidemiologiccardiovascular healthbirth outcomes
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 2 , April 2020 , pp. 188 - 195
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

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