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Does fetal leptin and adiponectin influence children’s lung function and risk of wheeze?

Published online by Cambridge University Press:  27 October 2020

Blanche C. Ip Open the ORCID record for Blanche C. Ip [Opens in a new window] ,
Nan Li ,
Medina Jackson-Browne ,
Melissa Eliot ,
Yingying Xu ,
Aimin Chen ,
Bruce P. Lanphear ,
Adam J. Spanier  and
Joseph M. Braun
Blanche C. Ip*
Affiliation:
Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA
Nan Li
Affiliation:
Department of Epidemiology, Brown University, Providence, RI, USA
Medina Jackson-Browne
Affiliation:
College of Health Sciences, University of Delaware, Newark, DE, USA
Melissa Eliot
Affiliation:
Department of Epidemiology, Brown University, Providence, RI, USA
Yingying Xu
Affiliation:
Cincinnati Children’s Hospital Medical Center, Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati, OH, USA
Aimin Chen
Affiliation:
Division of Epidemiology, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, USA Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Bruce P. Lanphear
Affiliation:
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada Child and Family Research Institute, BC Children’s Hospital, Vancouver, British Columbia, Canada
Adam J. Spanier
Affiliation:
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
Joseph M. Braun
Affiliation:
Department of Epidemiology, Brown University, Providence, RI, USA
*
Address for correspondence: Blanche C. Ip, BioMed Box G-B, Brown University, Providence, RI02912, USA. Email: [email protected]
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Abstract

Adipocytokines, which are secreted during fetal development by both mothers and fetuses, may influence fetal lung development, but little human data are available. We used data from the HOME Study to investigate the associations of cord blood adipocytokine concentrations with children’s lung forced expiratory volume (FEV1; N = 160) and their risk of wheeze (N = 281). We measured umbilical cord serum adipocytokine concentrations using enzyme-linked immunosorbent assays and FEV1 using a portable spirometer at ages 4 and 5 to calculate the percent predicted FEV1 (%FEV1). Parents completed standardized questionnaires of their child’s wheeze symptoms every 6 months from birth to age 5, then again at ages 6 and 8. We used multivariable linear mixed models and modified Poisson regression with generalized estimating equations to estimate associations of adipocytokine concentrations (log2-transformed) with children’s %FEV1 and the risk of wheeze, respectively, adjusting for sociodemographic, perinatal, and child factors. Cord serum leptin was not associated with children’s %FEV1. Higher cord serum adiponectin concentrations were associated with higher %FEV1 in girls (β = 3.1, 95% confidence interval [CI]: 0.6, 5.6), but not in boys (β = −1.3, 95% CI: −5.9, 3.3) (sex × adiponectin p-value = 0.05). Higher leptin was associated with lower risk of wheeze in girls (RR = 0.74, 95% CI: 0.66, 0.84), but not boys (RR = 0.87, 95% CI: 0.69, 1.11) (sex × leptin p-value = 0.01). In contrast, higher adiponectin concentrations were associated with lower risk of wheeze (RR = 0.84, 95% CI: 0.73, 0.96) in both boys and girls. These data suggest that fetal adipocytokines may impact lung development and function in early childhood. Future studies are needed to confirm these findings and explore the mechanisms underlying these associations.

Keywords

Adipocytokineschildrenlung functionwheeze
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 4 , August 2021 , pp. 570 - 577
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Copyright
© The Author(s), 2020. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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