Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-28T22:01:23.177Z Has data issue: false hasContentIssue false
  • English
  • Français

Developmental basis of disease: environmental impacts

Published online by Cambridge University Press:  23 February 2011

G. W. Collman
G. W. Collman*
Affiliation:
Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
*
*Address for correspondence: Dr G. W. Collman, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Gwen, PO Box 12233, Research Triangle Park, North Carolina 27709, USA. (Email [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Exposure to environmental chemicals and other environmental stressors have health impacts on the fetus that may not be apparent until later in life. The concept of developmental origins of disease should be expanded to include these early life exposures in addition to the effects of nutrition and maternal factors. This paper will describe the toxicological, biological and epidemiological issues that are pertinent to conducting research on environmental exposures early in life and their health consequences over the life span.

Keywords

early life exposuresenvironmental chemicalswindows of susceptibility
Type
Themed Content: Role of Environmental Stressors in the Developmental Origins of Disease
Information
Journal of Developmental Origins of Health and Disease , Volume 2 , Issue 1: Including Themed Content: Role of Environmental Stressors in the Developmental Origins of Disease , 23 February 2011 , pp. 49 - 55
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Barker, DJ, Osmond, C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986; 1, 1077–1081.CrossRefGoogle ScholarPubMed
2.Gillman, MW, Smith, GD, Hanson, MA. Developmental origins of health and disease across generations – theory, observations, experiment. In Early Life Origins of Human Health and Disease (eds. Newnham JP, Ross MG), 2009; pp. 52–64. Karger: Basel.CrossRefGoogle Scholar
3.Barr, DB, Bishop, A, Needham, LL. Concentrations of xenobiotic chemicals in the maternal-fetal unit. Reprod Toxicol. 2007; 23, 260–266.CrossRefGoogle ScholarPubMed
4.Whyatt, RM, Camann, D, Perera, FP, et al. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol. 2005; 206, 246–254.CrossRefGoogle ScholarPubMed
5.Bradman, A, Eskenazi, B, Barr, DB, et al. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environ Health Perspect. 2005; 113, 1802–1807.CrossRefGoogle Scholar
6.Ye, X, Pierik, FH, Angerer, J, et al. Levels of metabolites of organophosphate pesticides, phthalates and bis phenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort (MoBa). Int J Hyg Env Health. 2009; 212, 481–491.CrossRefGoogle Scholar
7.Altshuler, K, Berg, M, et al. Critical periods in development. OCHP Paper Series on Children's Health and the Environment. February 2003.Google Scholar
8.Suk, WA, Collman, GW. Genes and the environment: their impact on children's health. Environ Health Perspect. 1998; 106(Suppl. 3), 817–820.Google ScholarPubMed
9.Huen, K, Harley, K, Brooks, J, et al. Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms. Environ Health Perspect. 2009; 117, 1632–1638.CrossRefGoogle ScholarPubMed
10.Waterland, RA, Michels, K. Epigenetics epidemiology: the developmental origins hypothesis. Annu Rev Nutr. 2007; 27, 363–388.CrossRefGoogle ScholarPubMed
11.CDC, Fourth National Report on Human Exposure to Environmental Chemicals. 2009; http://www.cdc.gov/exposurereport/pdf/FourthReport.pdfGoogle Scholar
12.Wolff, MS, Teitelbaum, SL, Windham, G, et al. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect. 2007; 115, 116–121.CrossRefGoogle ScholarPubMed
13.Wolff, MS, Engel, SM, Berkowitz, GS, et al. Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect. 2008; 116, 1092–1097.CrossRefGoogle ScholarPubMed
14.Apelberg, BJ, Witter, FR, Herbstman, JB, et al. Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. Environ Health Perspect. 2007; 115, 1670–1676.CrossRefGoogle ScholarPubMed
15.Lovasi, GS, Quinn, JW, Rauh, VA, et al. Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment. Am J Public Health. 2010; 101, doi:10.2105/AJPH.2009.168419, 63–70.Google Scholar
16.Herbstman, JB, Sjödin, A, Kurzon, M, et al. Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect. 2010; 118, 712–719.CrossRefGoogle ScholarPubMed
17.Heindel, JJ, Newbold, R. Developmental origins of health and disease: the importance of environmental exposures. In Early Life Origins of Human Health and Disease (eds. Newnham JP, Ross MG), 2009; pp. 42–51. Karger: Basel.Google Scholar
18.Cohn, BA, Wolff, MS, Cirillo, PM, Sholtz, RI. DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect. 2007; 115, 1406–1414.CrossRefGoogle ScholarPubMed
19.Vandenberg, LN, Maffini, MV, Schaeberle, CM, et al. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reprod Toxicol. 2008; 26, 210–219.CrossRefGoogle Scholar
20.Nilsson, EE, Anway, MD, Stanfield, J, Skinner, MK. Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease. Reproduction. 2008; 135, 713–721.CrossRefGoogle ScholarPubMed
21.Skinner, MK, Manikkam, M, Guerrero-Bosagna, C. Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab. 2010; 21, 214–222.CrossRefGoogle ScholarPubMed
22.Davidson, PW, Myers, GJ, Cox, C, et al. . The Seychelles Child Development Study Group. Measuring neurodevelopmental outcomes of young children following prenatal dietary low-dose methylmercury exposures. Environ Sci. 1994; 3, 55–65.Google Scholar
23.Fängström, B, Athanasiadou, M, Grandjean, P, Weihe, P, Bergman, A. Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women. Environ Health Perspect. 2002; 110, 895–899.Google ScholarPubMed
24.Kimmel, CA, Collman, GW, Fields, N, Eskenazi, B. Lessons learned for the national children's study from the National Institute of Environmental Health Sciences/U.S. Environmental Protection Agency Centers for children's environmental health and disease prevention research. Environ Health Perspect. 2005; 113, 1415–1418.CrossRefGoogle ScholarPubMed
25.Eskenazi, B, Gladstone, EA, Berkowitz, GS, et al. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the centers for children's environmental health and disease prevention research. Environ Health Perspect. 2005; 113, 1419–1429.CrossRefGoogle ScholarPubMed
26.Hiatt, RA, Haslam, SZ, Osuch, J, Breast Cancer and the Environment Research Centers. The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology. Environ Health Perspect. 2009; 117, 1814–1822.CrossRefGoogle ScholarPubMed
27.Van den Berg, BJ, Christianson, RE, Oechsli, FW. The California child health and development studies of the School of Public Health, University of California at Berkeley. Paediatr Perinat Epidemiol. 1988; 2, 265–282.CrossRefGoogle ScholarPubMed
28.Barlow, BK, Cory-Slechta, DA, Richfield, EK, Thiruchelam, M. The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod Toxicol. 2007; 23, 257–470.CrossRefGoogle ScholarPubMed
29.Groopman, JD, Johnson, D, Kensler, TW. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomark 1. 2005; 1, 5–14.CrossRefGoogle ScholarPubMed
30.Schwartz, D, Collins, F. Medicine. Environmental biology and human disease. Science. 2007; 316, 695–696.CrossRefGoogle ScholarPubMed
31.Colquhoun, DR, Goldman, LR, Cole, RN, et al. Global screening of human cord blood proteomes for biomarkers of toxic exposure and effect. Environ Health Perspect. 2009; 117, 832–838.CrossRefGoogle ScholarPubMed
32.Betancourt, AM, Mobley, JA, Russo, J, Lamartiniere, CA. Proteomic analysis in mammary glands of rat offspring exposed in utero to bisphenol A. J Proteomics. 2010; 73, 1241–1253.CrossRefGoogle ScholarPubMed
33.Perera, F, Tang, WY, Herbstman, J, et al. Relation of DNA methylation of 5′-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One. 2009; 4, 4488 (1–14).CrossRefGoogle Scholar
34.President's Cancer Panel. Reducing environmental cancer risk, what we can do now. 2008–2009; http://deainfo.nci.nih.gov/advisory/pcp/pcp08-09rpt/PCP_Report_08-09_508.pdfGoogle Scholar
35.Harrill, AH, Ross, PK, Gatti, DM, Threadgill, DW, Rusyn, I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicol Sci. 2009; 110, 235–243. Epub 6 May 2009.CrossRefGoogle ScholarPubMed
36.Bauer, AK, Kleeberger, SR. Genetic mechanisms of susceptibility to ozone-induced lung disease. Ann N Y Acad Sci. 2010; 1203, 113–119.CrossRefGoogle ScholarPubMed
37.McGlynn, KA, Guo, X, Graubard, BI, et al. Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring. Environ Health Perspect. 2009; 117, 1472–1476.CrossRefGoogle ScholarPubMed