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Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

Part of: Advance Imaging in DOHaD

Published online by Cambridge University Press:  22 December 2020

G.D. Clarke Open the ORCID record for G.D. Clarke [Opens in a new window] ,
J. Li ,
A.H. Kuo ,
A.J. Moody  and
P.W. Nathanielsz
G.D. Clarke*
Affiliation:
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J. Li
Affiliation:
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
A.H. Kuo
Affiliation:
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
A.J. Moody
Affiliation:
Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
P.W. Nathanielsz
Affiliation:
Department of Animal Science, University of Wyoming, Laramie, WY, USA
*
Address for correspondence: GD Clarke, Department of Radiology, University of Texas Health Science Center at San Antonio and Research Imaging Institute, University of Texas Health Science Center at San Antonio and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Email: [email protected]
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Abstract

Cardiovascular diseases (CVD) are important consequences of adverse perinatal conditions such as fetal hypoxia and maternal malnutrition. Cardiac magnetic resonance imaging (CMR) can produce a wealth of physiological information related to the development of the heart. This review outlines the current state of CMR technologies and describes the physiological biomarkers that can be measured. These phenotypes include impaired ventricular and atrial function, maladaptive ventricular remodeling, and the proliferation of myocardial steatosis and fibrosis. The discussion outlines the applications of CMR to understanding the developmental pathways leading to impaired cardiac function. The use of CMR, both in animal models of developmental programming and in human studies, is described. Specific examples are given in a baboon model of intrauterine growth restriction (IUGR). CMR offers great potential as a tool for understanding the sequence of dysfunctional adaptations of developmental origin that can affect the human cardiovascular system.

Keywords

Heart diseasecardiac MRIventricular remodelingdevelopmental programming
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 2 , April 2021 , pp. 203 - 219
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Copyright
© The Author(s), 2020. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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