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Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days

Published online by Cambridge University Press:  30 April 2015

C. R. Pessanha ,
B. Ferolla da Camara Boueri ,
L. Rodrigues da Costa ,
M. Rocha Ferreira ,
H. Saldanha Melo ,
M. Duque Coutinho de Abreu ,
L. Rozeno Pessoa ,
P. C. Alves da Silva ,
A. D’Avila Pereira  and
D. Cavalcante Ribeiro
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C. R. Pessanha
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
B. Ferolla da Camara Boueri
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
L. Rodrigues da Costa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
M. Rocha Ferreira
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
H. Saldanha Melo
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
M. Duque Coutinho de Abreu
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
L. Rozeno Pessoa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
P. C. Alves da Silva
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
A. D’Avila Pereira
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
D. Cavalcante Ribeiro
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
J. Azevedo de Meneses
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
C. A. Soares da Costa
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
G. T. Boaventura*
Affiliation:
Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil
*
*Address for correspondence: G. T. Boaventura, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rua Mário Santos Braga 30, Niterói, RJ 24015-110, Brazil. (Email [email protected])
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Abstract

The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.

Keywords

brainearly weaningflaxseedrat
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Issue 4 , August 2015 , pp. 268 - 271
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2015 

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