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Intrauterine exposure to smoking and wheezing in adolescence: the 1993 Pelotas Birth Cohort

Published online by Cambridge University Press:  18 November 2014

F. C. Werhmeister ,
B. P. Nunes ,
C. Loret de Mola Open the ORCID record for C. Loret de Mola [Opens in a new window] ,
N. Gómez-Cofré ,
P. D. de Oliveira ,
P. L. Marco ,
M. C. F. Assunção ,
H. Gonçalves ,
B. L. Horta  and
A. M. B. Menezes
F. C. Werhmeister*
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
B. P. Nunes
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
C. Loret de Mola
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
N. Gómez-Cofré
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
P. D. de Oliveira
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
P. L. Marco
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
M. C. F. Assunção
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
H. Gonçalves
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
B. L. Horta
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
A. M. B. Menezes
Affiliation:
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
*
*Address for correspondence: F. C. Wehrmeister, Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, no 1160, 3o piso, CEP 96020-220, Pelotas/RS, Brazil. (Email [email protected])
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Abstract

Previous studies have suggested an association between maternal smoking during pregnancy and asthma symptoms such as wheezing during childhood. However, few have evaluated this association in adolescence, especially in populations with high prevalence of wheezing as in Brazil. Using the 1993 Pelotas birth cohort, a longitudinal study set in southern Brazil of 5249 urban live births, we aimed to evaluate the association between maternal and the partner’s smoking during pregnancy and wheezing at 11 and 15 years of age. We evaluated smoking during pregnancy using number of cigarettes/day, and our main outcomes were as follows: wheezing in the last year and number of wheezing crises, at both 11 and 15 years of age, as well as persistent wheezing (having crises at 11 and 15 years of age) and medical asthma diagnosis at age 15. In addition, other socio-demographic variables were included as possible confounders and mediators of this association. We used Poisson regression models to evaluate crude and adjusted associations. Of the 5249 live births in 1993, 87.5% and 85.7% were followed-up to 11 and 15 years of age, respectively. Maternal smoking during pregnancy showed a dose-response association with number of wheezing crises at age 15 (P=0.023), presence of persistent wheezing (P=0.034) and asthma diagnosis (P=0.023). Partner’s smoking was not associated with any wheezing variables. Maternal smoking during pregnancy appears to exert an effect on respiratory morbidity of adolescents, evaluated by wheezing symptoms.

Keywords

adolescentlongitudinal studiespregnancyrespiratory soundssmoking
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 6 , Supplement 3 , June 2015 , pp. 217 - 224
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2014 

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