Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-27T03:20:09.219Z Has data issue: false hasContentIssue false
  • English
  • Français

Birth weight influences the kidney size and function of Bangladeshi children

Part of: DOHaD in Indigenous Populations DOHaD on International Women's Day 2020 French DOHaD

Published online by Cambridge University Press:  18 December 2017

F. Ferdous ,
E. Ma ,
R. Raqib  and
Y. Wagatsuma
F. Ferdous*
Affiliation:
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
E. Ma
Affiliation:
Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
R. Raqib
Affiliation:
International Centre for Diarrhoeal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh
Y. Wagatsuma
Affiliation:
Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
*
*Address for correspondence: F. Ferdous, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. (Email [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Early-life conditions influence organ growth patterns and their functions, as well as subsequent risk for non-communicable chronic diseases in later life. A limited number of studies have determined that in Bangladesh, kidney size relates to its function among children as a consequence of the maternal and postnatal conditions. The present study objectives were to determine early-life conditions in relation to childhood kidney size and to compare their influences on kidney function. The study was embedded in a population-based prospective cohort of 1067 full-term singleton live births followed from fetal life onward. Kidney volume was measured by ultrasound in children at the age of 4.5 years (range 45–64 months), and the estimated glomerular filtration rate (eGFR) was assessed at the age of 9 years (range 96–116 months). The mean (s.d.) kidney volume of children at 4.5 years was 64.2 (11.3) cm3, with a significant mean difference observed between low birth weight and normal birth weight children (P<0.001). The multivariable model showed, changes in status from low birth weight to normal birth weight children, with kidney volume increases of 2.92 cm3/m2, after adjusting for the child’s age, sex, maternal age and early pregnancy body mass index, and socio-economic index variables. One-unit change in kidney volume (cm3/m2) improved the eGFR to 0.18 ml/min/1.73 m2. The eGFR in low birth weight children was 5.44 ml/min/1.73 m2 less than that in normal birth weight children after adjustments. Low birth weight leads to adverse effects on kidney size and function in children.

Keywords

birth weightchildrenestimated glomerular filtration rate (eGFR)kidney volume
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 4: Themed Issue: French DOHaD , August 2018 , pp. 386 - 394
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lee, MJ, Son, MK, Kwak, BO, et al. Kidney size estimation in Korean children with Technesium-99m dimercaptosuccinic acid scintigraphy. Korean J Pediatr. 2014; 57, 41–45.Google Scholar
2. Luyckx, VA, Bertram, JF, Brenner, BM, et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet. 2013; 382, 273–283.Google Scholar
3. Geelhoed, JJ, Verburg, BO, Nauta, J, et al. Tracking and determinants of kidney size from fetal life until the age of 2 years: the Generation R Study. Am J Kidney Dis. 2009; 53, 248–258.10.1053/j.ajkd.2008.07.030Google Scholar
4. Abitbol, CL, DeFreitas, MJ, Strauss, J. Assessment of kidney function in preterm infants: lifelong implications. Pediatr Nephrol. 2016; 31, 2213–2222.Google Scholar
5. Hinchliffe, SA, Sargent, PH, Howard, CV, Chan, YF, van Velzen, D. Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest. 1991; 64, 777–784.Google Scholar
6. Hughson, M, Farris, AB 3rd, Douglas-Denton, R, Hoy, WE, Bertram, JF. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int. 2003; 63, 2113–2122.Google Scholar
7. Langley-Evans, SC, Welham, SJ, Jackson, AA. Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat. Life Sci. 1999; 64, 965–974.Google Scholar
8. Hinchliffe, SA, Lynch, MR, Sargent, PH, Howard, CV, Van Velzen, D. The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol. 1992; 99, 296–301.Google Scholar
9. Persson, LA, Arifeen, S, Ekstrom, EC, et al. Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial. JAMA. 2012; 307, 2050–2059.Google Scholar
10. Neufeld, LM, Wagatsuma, Y, Hussain, R, Begum, M, Frongillo, EA. Measurement error for ultrasound fetal biometry performed by paramedics in rural Bangladesh. Ultrasound Obstet Gynecol. 2009; 34, 387–394.Google Scholar
11. Geelhoed, JJ, Kleyburg-Linkers, VE, Snijders, SP, et al. Reliability of renal ultrasound measurements in children. Pediatr Nephrol. 2009; 24, 1345–1353.Google Scholar
12. Wollmann, HA. Intrauterine growth restriction: definition and etiology. Horm Res. 1998; 49(Suppl. 2), 1–6.Google Scholar
13. Zappitelli, M, Parvex, P, Joseph, L, et al. Derivation and validation of cystatin C-based prediction equations for GFR in children. Am J Kidney Dis. 2006; 48, 221–230.Google Scholar
14. Haycock, GB, Schwartz, GJ, Wisotsky, DH. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr. 1978; 93, 62–66.Google Scholar
15. Smith, HW. The Kidney. Structure and Function in Health and Disease. 1951. Oxford University Press: New York.Google Scholar
16. Konus, OL, Ozdemir, A, Akkaya, A, et al. Normal liver, spleen, and kidney dimensions in neonates, infants, and children: evaluation with sonography. Am J Roentgenol. 1998; 171, 1693–1698.Google Scholar
17. Iyengar, A, Nesargi, S, George, A, et al. Are low birth weight neonates at risk for suboptimal renal growth and function during infancy? BMC Nephrol. 2016; 17, 100.Google Scholar
18. Keijzer-Veen, MG, Kleinveld, HA, Lequin, MH, et al. Renal function and size at young adult age after intrauterine growth restriction and very premature birth. Am J Kidney Dis. 2007; 50, 542–551.10.1053/j.ajkd.2007.06.015Google Scholar
19. Eze, CU, Agwu, KK, Ezeasor, DN, et al. Sonographic biometry of normal kidney dimensions among school-age children in Nsukka, Southeast Nigeria. West Indian Med J. 2014; 63, 46–53.Google Scholar
20. Spencer, J, Wang, Z, Hoy, W. Low birth weight and reduced renal volume in Aboriginal children. Am J Kidney Dis. 2001; 37, 915–920.Google Scholar
21. Emamian, SA, Nielsen, MB, Pedersen, JF, Ytte, L. Kidney dimensions at sonography: correlation with age, sex, and habitus in 665 adult volunteers. Am J Roentgenol. 1993; 160, 83–86.Google Scholar
22. White, SL, Perkovic, V, Cass, A, et al. Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis. 2009; 54, 248–261.Google Scholar
23. Brenner, BM, Garcia, DL, Anderson, S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens. 1988; 1, 335–347.Google Scholar
24. Hoy, WE, Hughson, MD, Bertram, JF, Douglas-Denton, R, Amann, K. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol. 2005; 16, 2557–2564.Google Scholar
25. Luyckx, VA, Brenner, BM. The clinical importance of nephron mass. J Am Soc Nephrol. 2010; 21, 898–910.Google Scholar
26. Nyengaard, JR, Bendtsen, TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec. 1992; 232, 194–201.Google Scholar
27. Costello, JM, Polito, A, Brown, DW, et al. Birth before 39 weeks’ gestation is associated with worse outcomes in neonates with heart disease. Pediatrics. 2010; 126, 277–284.Google Scholar
28. Neugarten, J, Golestaneh, L. Gender and the prevalence and progression of renal disease. Adv Chronic Kidney Dis. 2013; 20, 390–395.Google Scholar
29. Lindstrom, E, Hossain, MB, Lonnerdal, B, et al. Prevalence of anemia and micronutrient deficiencies in early pregnancy in rural Bangladesh, the MINIMat trial. Acta Obstet Gynecol Scand. 2011; 90, 47–56.Google Scholar
30. Christian, P, Stewart, CP. Maternal micronutrient deficiency, fetal development, and the risk of chronic disease. J Nutr. 2010; 140, 437–445.Google Scholar
31. Chowdhury, MA, Uddin, MJ, Haque, MR, Ibrahimou, B. Hypertension among adults in Bangladesh: evidence from a national cross-sectional survey. BMC Cardiovasc Disord. 2016; 16, 22.Google Scholar
32. Malik, A. Congenital and acquired heart diseases: (a survey of 7062 persons). Bangladesh Med Res Counc Bull. 1976; 2, 115–119.Google Scholar
33. Anand, S, Khanam, MA, Saquib, J, et al. High prevalence of chronic kidney disease in a community survey of urban Bangladeshis: a cross-sectional study. Global Health. 2014; 10, 9.Google Scholar
34. Hawkes, C, Webster, J. National approaches to monitoring population salt intake: a trade-off between accuracy and practicality? PLoS One. 2012; 7, e46727.Google Scholar
35. Meneton, P, Jeunemaitre, X, de Wardener, HE, MacGregor, GA. Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases. Physiol Rev. 2005; 85, 679–715.Google Scholar
Supplementary material: File

Ferdous et al. supplementary material

Table S1

Download Ferdous et al. supplementary material(File)
File 92.2 KB