Hostname: page-component-745bb68f8f-cphqk Total loading time: 0 Render date: 2025-01-11T15:50:33.223Z Has data issue: false hasContentIssue false
  • English
  • Français

Intramammary pressure and luteal oxytocin after PGF2α administration in cycling and early pregnant ewes

Published online by Cambridge University Press:  01 June 2009

Pierre-Guy Marnet  and
Jacques Labussière
Pierre-Guy Marnet
Affiliation:
INRA, Laboratoire de Recherches sur la Traite, ENSAR, 65 rue de Saint-Brieuc, 35042 Rennes Cédex, France
Jacques Labussière
Affiliation:
INRA, Laboratoire de Recherches sur la Traite, ENSAR, 65 rue de Saint-Brieuc, 35042 Rennes Cédex, France
Get access Rights & Permissions [Opens in a new window]

Summary

The aim of this work was to investigate whether luteal oxytocin released after non-luteolytic prostaglandin F2α (PGF2α) challenge could explain the intramammary pressure (IMP) rises previously described in pregnant ewes after the normal life span of a corpus luteum. Blood oxytocin levels and IMP after challenge were measured in cycling and pregnant lactating ewes until the response ceased (˜ 55 d post oestrus). Oxytocin release was not significantly different for cycling and pregnant ewes, and fell to its lowest levels on days 16–18 post oestrus in both groups, i.e. with or without luteolysis. However, although IMP response fell with luteolysis in cycling ewes, the response persisted until day 55 in pregnant ewes. This lack of correlation between oxytocin release and IMP response raised interesting questions including: is there an unknown oxytocic compound that can be released after PGF2α stimulation of the corpora lutea?

Type
Original Articles
Information
Journal of Dairy Research , Volume 61 , Issue 3 , August 1994 , pp. 345 - 353
Copyright
Copyright © Proprietors of Journal of Dairy Research 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Amico, J. A. & Hempel, J. 1990 An oxytocin precursor intermediate circulates in the plasma of humans and rhesus monkeys adminstered estrogen. Neuroendocrinology 51 437–443CrossRefGoogle Scholar
Bennegard, B., Dennefors, B. & Hamberger, L. 1984 Interaction between catecholamincs and PCF2α in human luteolysis. Acta Endocrinologica 106 532–537Google Scholar
Curto, G. M., Baldissera-Nordio, C. & Greppi, G. F. 1973 [Effect of PGF2α on milk ejection in the cow.] Rivista di Zootecnia e Veterinaria no. 1 77–78Google Scholar
Curto, G. M., Baldissera-Nordio, C., Rukfini, Castrovilli C., Greppi, G. F. & Uccelli, S. 1976 [Masteocynetic activity of prostaglandin F2α versus oxytocin.] Rivista di Zootecnia e Veterinaria no. 2 163–171Google Scholar
Dhont, G., Houvenaghel, A., Peeters, G. & Jöchle, W. 1977 Effect of prostaglandins F2α and E2 on milk ejection, blood pressure and blood flow through the mammary artery in the cow. Prostaglandins 13 1185–1199CrossRefGoogle Scholar
Fehr, S., Ivell, R., Koll, R., Schams, D., Fields, M. & Richter, D. 1987 Expression of the oxytocin gene in the large cells of the bovine corpus lutcum. FEBS Letters 210 45–50CrossRefGoogle Scholar
Flint, A. P. F. & Sheldrick, E. L. 1983 Evidence for a systemic role for ovarian oxytocin in lutcal regression in sheep. Journal of Reproduction and Fertility 67 215–225CrossRefGoogle ScholarPubMed
Flint, A. P. F., Sheldrick, E. L., McCann, T. J. & Jones, D. S. C. 1990 Luteal oxytocin: characteristics and control of synchronous episodes of oxytocin and PGF2α secretion at luteolysis in ruminants. Domestic Animal Endocrinology 7 111–124CrossRefGoogle ScholarPubMed
Furuya, K., McArdle, C. A. & Ivell, R. 1990 The regulation of oxytocin gene expression in early bovine lutcal cells. Molecular and Cellular Endocrinology 70 81–88CrossRefGoogle ScholarPubMed
Garcia-Villar, R., Marnet, P. G., Laurentie, M. P. & Toutain, P. L. 1985 Relative oxytocic properties of Fenprostalene compared with cloprostenol, prostaglandin F2α, and oxytocin in the ovariectomized ewe. American Journal of Veterinary Research 46 841–844Google ScholarPubMed
Homeida, A. M. & Cooke, R. G. 1983 Suppression of pulsatile release of oxytocin during early pregnancy in the goat. Prostaglandins 26 103–109CrossRefGoogle ScholarPubMed
Hoofer, S. B., Walker, D. W. & Thorbukn, G. D. 1986 Cannulation of the utero-ovarian vein in intact ewes: hormone concentrations and blood gas levels during the oestrous cycle and early pregnancy. Acta Endocrinologica 112 253–262Google Scholar
Ivell, R., Brackett, K. H., Fields, M. J. & Richter, D. 1985 Ovulation triggers oxytocin gene expression in the bovine ovary. FEBS Letters 190 263–267CrossRefGoogle ScholarPubMed
Jones, D. S. C. & Flint, A. P. F. 1988 Concentrations of oxytocin-ncurophysin prohormone mRNA in corpora lutea of sheep during the oestrous cycle and early pregnancy. Journal of Endocrinology 117 409–414CrossRefGoogle ScholarPubMed
Labussière, J., Combaud, J.-F. & De La Chevalerie, F. A. 1988 a PGF2α-induced milk ejection in ewes having cyclic or pregnant corpora lutea. Reproduction, Nutrition, Développement 28 541–552Google ScholarPubMed
Labussière, J., Lacroix, M. C., Combaud, J.-F., De La Chevalerie, F. A. & Thomas, P. 1990 [Suppression by lutectomy of simultaneous intramammary pressure and oxytocin increases induced by intrajugular PGF2αt administration in the ewe.] Reproduction, Nutrition, Development 30 91–96Google Scholar
Labussière, J., Marnet, P. G., Combaud, J.-F., Beaufils, M. & De La Chevalerie, F. A. 1993 [Influence of the number of corpora lutea on the release of luteal oxytocin, milk transference from alveolar to cisternal lumen and milk production in the ewe.] Reproduction, Nutrition, Development 33 383–393Google Scholar
Labussière, J., Philibert, C., Combaud, J.-F. & Dotchevski, D. 1982 [Effectiveness of PGF2α on milk ejection during the oestrous cycle in the cow.] Reproduction, Nutrition, Développement 22 49–63Google Scholar
Labussière, J., Philibert, C., Dotchevski, D., Combaud, J.-F., De La Chevalerie, F. A. & Bernabé, J. 1983 [Effects of prostaglandin F2α on milk ejection in the ewe. Variations during the oestrous cycle.] Proceedings of the third International Symposium on Machine Milking of Small Ruminants Valladolid, Spain, 64–80Google Scholar
Labussière, J., Ruiz, M.-C. & Combaud, J.-F. 1980 [Attempt to explain the rise of intramammary pressure after water injection in inguinal artery in the ewe.] Reproduction, Nutrition, Développement 20 1503–1513Google Scholar
Labussière, J., Thomas, P., Combaud, J.-F. & De La Chevalerie, F. A. 1988 b [PGF2α-induced milk ejection during the first two months after artificial insemination in cows. Implications for a new pregnancy diagnosis.] Reproduction, Nutrition, Développement 28 899–907Google Scholar
Lamsa, J. C., Kot, S. J., Eldering, J. A., Nay, M. G. & McCracken, J. A. 1989 Prostaglandin F2α- stimulated release of ovarian oxytocin in the sheep in vivo: threshold and dose dependency. Biology of Reproduction 40 1215–1223CrossRefGoogle ScholarPubMed
Lucas, F. 1992 [Galactopoietic Effect of Follicle-Stimulating Treatments in the Lacaune Ewe. Release pattern, of luteal oxytocin after PGF2α. challenge.] Thesis, Master of animal physiology, University of Rennes I 34 pp.Google Scholar
McArdle, C. A. 1990 Chronic regulation of ovarian oxytocin and progesterone release by prostaglandins: opposite effects in bovine granulosa and early luteal cells. Journal of Endocrinology 126 245–253CrossRefGoogle ScholarPubMed
McArdle, C. A. & Holtorf, A.-P. 1989 Oxytocin and progesterone release from bovine corpus luteal cells in culture: effects of insulin-like growth factor I, insulin, and prostaglandins. Endocrinology 124 1278–1286CrossRefGoogle ScholarPubMed
McCann, T. J. & Flint, A. P. F. 1990 Effects of prostaglandin F2α and other potential secretagogues on oxytocin secretion and second messenger metabolism in the ovine corpus luteum in vitro. Journal of Endocrinology 126 89–98CrossRefGoogle ScholarPubMed
Marnet, P. G., Labussière, J., Beaufils, M. & Combaud, J.-F. 1993 Use of a new technique for studying basal levels of oxytocin during the oestrous cycle and stimulated levels of oxytocin after PGF2α challenges in ewes of the Lacaune breed with increased number of corpora lutea. Proceedings of the fifth International Symposium on Machine Milking of Small Ruminants. Budapest, Hungary; Hungarian Journal of Animal Production (Suppl. 1) 78–89Google Scholar
Marnet, P. G., Volland, H., Pradelles, P., Grassi, J. & Beaufils, M. 1994 Subpiegram determination of oxytocin in ruminant plasma by a new enzyme immunoassay technique using acetylcholinesterase as label. Journal of Immunoassay 15 35–53CrossRefGoogle Scholar
Mayer, H., Weber, F. & Segessemann, V. 1989 Oxytocin release and milking characteristics of Ostfriesian and Lacaune dairy sheep. In Proceedings of 4th International Symposium on Machine Milking of Small Ruminants, pp. 548–563 (Moshe Eitam Edit. Ministry of Agriculture, Israël)Google Scholar
Murdoch, W. J. 1990 Localization and hormonal regulation of ovarian production of histamine in the sheep. Life Sciences 46 1961–1965CrossRefGoogle ScholarPubMed
Robinson, I. C. A. F. 1980 The development and evaluation of a sensitive and specific radioimmunoassay for oxytocin in unextractcd plasma. Journal of Immunoassay 1 323–347CrossRefGoogle ScholarPubMed
Schallenberger, E., Schams, D., Bullermann, B. & Walters, D. L. 1984 Pulsatile Secretion of gonadotrophins, ovarian steroids and ovarian oxytocin during prostaglandin-induced regression of the corpus luteum in the cow. Journal of Reproduction and Fertility 71 493–501CrossRefGoogle ScholarPubMed
Schams, D. 1983 Oxytocin determination by radioimmunoassay. III. Improvement of subpieogram sensibility and application to blood levels in cyclic cattle. Acta Endocrinologica 103 180–183Google Scholar
Schams, D. & Lahlou, Kassi A. 1984 Circulating concentrations of oxytocin during pregnancy in ewes. Acta Endocrinologica 106 277–281Google ScholarPubMed
Schams, D., Mayer, H., Prokopp, A. & Worstorff, H. 1984 Oxytocin secretion during milking in dairy cows with regard to the variation and importance of a threshold level for milk removal. Journal of Endocrinology 102 337–343CrossRefGoogle Scholar
Schramm, W., Einer-Jensen, N., Schramm, G. & McCracken, J. A. 1986 Local exchange of oxytocin from the ovarian vein to ovarian arteries in sheep. Biology of Reproduction 34 671–680CrossRefGoogle ScholarPubMed
Sheldrick, E. L. & Flint, A. P. F. 1984 Ovarian oxytocin and luteal function in the early pregnant sheep. Animal Reproduction Science 7 101–113CrossRefGoogle Scholar
Symonds, E. M. 1988 Renin and reproduction. American Journal of Obstetrics and Gynecology 158 754–761CrossRefGoogle ScholarPubMed
Wathes, D. C., Guldenaar, S. E. F., Swann, R. W., Webb, R., Porter, D. G. & Pickering, B. T. 1986 A combined radioimmunoassay and immunocytochemical study of ovarian oxytocin production during the periovulatory period of the ewe. Journal of Reproduction and Fertility 78 167–183CrossRefGoogle ScholarPubMed
Wathes, D. C. & Swann, R. W. 1982 Is oxytocin an ovarian hormone? Nature 297 225–227CrossRefGoogle ScholarPubMed
Wathes, D. C., Swann, R. W. & Pickering, B. T. 1984 Variations in oxytocin, vasopressin and neurophysin concentrations in the bovine ovary during the oestrous cycle and pregnancy. Journal of Reproduction and Fertility 71 551–557CrossRefGoogle Scholar
Webb, R., Mitchell, M. D., Falconer, J. & Robinson, J. S. 1981 Temporal relationships between peripheral plasma concentrations of oxytocin, progesterone and 13, 14 dihydro-15-keto prostaglandin F2α during the oestrous cycle and early pregnancy in the ewe. Prostaglandins 22 443–454CrossRefGoogle ScholarPubMed