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Immune enhancement conferred by oral delivery of Lactobacillus rhamnosus HN001 in different milk-based substrates

Published online by Cambridge University Press:  16 April 2002

HARSHARNJIT S. GILL  and
KAY J. RUTHERFURD
HARSHARNJIT S. GILL
Affiliation:
Milk & Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
KAY J. RUTHERFURD
Affiliation:
Milk & Health Research Centre, Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand
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Abstract

The probiotic Lactobacillus rhamnosus HN001 is known to enhance immunity in animal models, following oral delivery. In this study, we investigated the immunoenhancing effects of HN001 delivered to mice in different milk-based substrates, including: whole (full-fat) milk supplemented with HN001; fermented milk supplemented with HN001; or whole milk which had been part-fermented by HN001. Direct oral feeding of mice with HN001 in whole milk was shown to enhance the phagocytic activity of blood and peritoneal cells. Similar effects on phagocytosis were observed when HN001 was offered to mice in the form of a milk- or fermented milk-based diet. The degree of immune enhancement conferred by HN001 was similar whether the probiotic was used as an additive or as a fermentative agent. These studies confirm that Lb. rhamnosus HN001, derived originally from dairy food, enhances immune function following oral delivery in different milk bases.

Keywords

Lactobacillusimmune-enhancementphagocytosismilkfermented milk
Type
Original Article
Information
Journal of Dairy Research , Volume 68 , Issue 4 , November 2001 , pp. 611 - 616
Copyright
Proprietors of Journal of Dairy Research 2001

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