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Functional and technological properties of camel milk proteins: a review

Published online by Cambridge University Press:  15 November 2016

Yonas Hailu*
Affiliation:
Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark Haramaya University, School of Animal and Range Sciences, P.O. Box 138, Dire Dawa, Ethiopia
Egon Bech Hansen
Affiliation:
Technical University of Denmark, National Food Institute, 2860-Søborg, Denmark
Eyassu Seifu
Affiliation:
Department of Food Science and Technology, Botswana University of Agriculture and Natural Resources, Private Bag 0027, Botswana
Mitiku Eshetu
Affiliation:
Haramaya University, School of Animal and Range Sciences, P.O. Box 138, Dire Dawa, Ethiopia
Richard Ipsen
Affiliation:
Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark
Stefan Kappeler
Affiliation:
M+W Central Europe GmbH, Gewerbestr. 12, 4123 Allschwil/Basel, Schweiz
*
*For correspondence; e-mail: [email protected] & [email protected]

Abstract

This review summarises current knowledge on camel milk proteins, with focus on significant peculiarities in protein composition and molecular properties. Camel milk is traditionally consumed as a fresh or naturally fermented product. Within the last couple of years, an increasing quantity is being processed in dairy plants, and a number of consumer products have been marketed. A better understanding of the technological and functional properties, as required for product improvement, has been gained in the past years. Absence of the whey protein β-LG and a low proportion of к-casein cause differences in relation to dairy processing. In addition to the technological properties, there are also implications for human nutrition and camel milk proteins are of interest for applications in infant foods, for food preservation and in functional foods. Proposed health benefits include inhibition of the angiotensin converting enzyme, antimicrobial and antioxidant properties as well as an antidiabetogenic effect. Detailed investigations on foaming, gelation and solubility as well as technological consequences of processing should be investigated further for the improvement of camel milk utilisation in the near future.

Type
Review Article
Copyright
Copyright © Proprietors of Journal of Dairy Research 2016 

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References

Abbas, S, Ashraf, H, Nazir, A & Sarfraz, L 2013 Physico-chemical analysis and composition of camel milk. International Researchers 2 8298 Google Scholar
Agrawal, RP, Jain, S, Shah, S, Chopra, A & Agarwal, V 2011 Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial. European Journal of Clinical Nutrition 65 10481052 CrossRefGoogle ScholarPubMed
Al haj, OA & Al Kanhal, HA 2010 Compositional, technological and nutritional aspects of dromedary camel milk. International Dairy Journal 20 811821 CrossRefGoogle Scholar
Attia, H, Kherouatou, N, Nasria, M & Khorchani, T 2000 Characterization of the dromedary milk casein micelle and study of its changes during acidification. Le Lait 80 503515 Google Scholar
Beg, OU, von Bahr-Lindström, H, Zaidi, ZH & Jörnvall, H 1985 The primary structure of α-lactalbumin from camel milk. European Journal of Biochemistry 147 233239 Google Scholar
Beg, OU, Bahr-Lindstrom, HV, Zaidi, ZH & Jornvall, H 1986a A camel milk whey protein rich in half-cystine: primary structure, assessment of variations, internal repeat patterns, and relationships with neurophysin and other active polypeptides. European Journal of Biochemistry 159 195201 CrossRefGoogle Scholar
Beg, OU, Bahr-Lindström, HV, Zaidi, ZH & Jörnvall, H 1986b Characterization of a camel milk protein rich in proline identifies a new β-casein fragment. Regulatory Peptides 15 5562 Google Scholar
Boehmer, JL, Ward, JL, Peters, RR, Shefcheck, KJ, McFarland, MA & Bannerman, DD 2010 Proteomic analysis of the temporal expression of bovine milk proteins during coliform mastitis and label-free relative quantification. Journal of Dairy Science 93 593603 CrossRefGoogle ScholarPubMed
Bornaz, S, Sahli, A, Attalah, A & Attia, H 2009 Physicochemical characteristics and renneting properties of camels’ milk: a comparison with goats’, ewes’ and cows’ milks. International Journal of Dairy Technology 62 505513 Google Scholar
Boye, JI, Alli, I, Ismail, AA, Gibbs, BF & Konishi, Y 1995 Factors affecting molecular characteristics of whey protein gelation. International Dairy Journal 5 337353 CrossRefGoogle Scholar
Brulé, G, Lenoir, J, Remeuf, F, Eck, A, Gillis, JC & others 2000 Chapter 1, the casein micelle and milk coagulation. In Cheese Making from Science to Quality Assurance, pp. 740 (2nd Eds Eck, A & JC, Gillis). UK, Intercept LtdGoogle Scholar
Caessens, PWJR, Gruppen, H, Visser, S, Van Aken, GA & Voragen, AGJ 1997 Plasmin hydrolysis of β-Casein: foaming and emulsifying properties of the fractionated hydrolysate. Journal of Agricultural and Food Chemistry 45 29352941 CrossRefGoogle Scholar
Chatterton, DEW, Smithers, G, Roupas, P & Brodkorb, A 2006 Bioactivity of β-lactoglobulin and α-lactalbumin-technological implications for processing. International Dairy Journal 16 12291240 CrossRefGoogle Scholar
Conesa, C, Sánchez, L, Rota, C, Pérez, MD, Calvo, M, Farnaud, S & Evans, RW 2008 Isolation of lactoferrin from milk of different species: calorimetric and antimicrobial studies. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 150 131139 Google Scholar
Desouky, MM, Shalaby, SM & Soryal, KA 2013 Compositional, rheological and organoleptic qualities of camel milk labneh as affected by some milk heat treatments. World Journal of Dairy and Food Science 8 118130 Google Scholar
De wit, JN 1998 Nutritional and functional characteristics of whey proteins in food products. Journal of Dairy Science 81 597608 CrossRefGoogle ScholarPubMed
Dickinson, E 1999 Adsorbed protein layers at fluid interfaces: interactions, structure and surface rheology. Colloids and Surfaces B: Biointerfaces 15 161176 Google Scholar
Dziuba, B & Dziuba, M 2014 Milk proteins-derived bioactive peptides in dairy products: molecular, biological and methodological aspects. Acta Scientiarum Polonorum Technologia Alimentaria 13 525 Google Scholar
El-Agamy, EI 2000 Effect of heat treatment on camel milk proteins with respect to antimicrobial factors: a comparison with cows’ and buffalo milk proteins. Food Chemistry 68 227232 Google Scholar
El-Agamy, EI 2006 Camel milk. In Handbook of Milk Non-bovine Mammals, pp. 297344 (Eds Park, YW & Haenlein, GF). Iowa, USA: Blackwell Publishing CrossRefGoogle Scholar
El-Agamy, EI 2007 The challenge of cow milk protein allergy. Small Ruminant Research 68 6472 CrossRefGoogle Scholar
El-Agamy, EI, Ruppanner, R, Ismail, A, Champagne, CPP & Assaf, R 1996 Purification and characterization of lactoferrin, lactoperoxidase, lysozyme and immunoglobulins from camel's milk. International Dairy Journal 6 129145 Google Scholar
El-Hatmi, H, Levieux, A & Levieux, D 2006 Camel (Camelus dromedarius) immunoglobulin G, α-lactalbumin, serum albumin and lactoferrin in colostrum and milk during the early postpartum period. Journal of Dairy Research 73 288293 Google Scholar
El-Hatmi, H, Girardet, JM, Gaillard, JL, Yahyaoui, MH & Attia, H 2007 Characterisation of whey proteins of camel (Camelus dromedarius) milk and colostrum. Small Ruminant Research 70 267271 Google Scholar
Farah, Z 1996 Camel milk. Properties and Products. St. Gallen, Switzerland: SKATGoogle Scholar
Farah, Z & Atkins, D 1992 Heat coagulation of camel milk. Journal of Dairy Research 59 229231 Google Scholar
Felfoul, I, Lopez, C, Gaucheron, F, Attia, H & Ayadi, MA 2015 Fouling behavior of camel and cow milks under different heat treatments. Food and Bioprocess Technology 8 17711778 CrossRefGoogle Scholar
Foegeding, EA, Davis, JP, Doucet, D & McGuffey, MK 2002 Advances in modifying and understanding whey protein functionality. Trends in Food Science and Technology 13 151159 Google Scholar
Fox, PF 2003 The major constituents of milk. In Dairy Processing, Improving Quality, pp. 5–38 (Ed. Smit, G). Cambridge, England: Woodhead Publishing Limited Google Scholar
Fox, PF & Mcsweeney, PLH 1998 Dairy Chemistry and Biochemistry, pp. 478. NY: Kluwer Academic/Plenum Publisher Google Scholar
Girardet, JM, Saulnier, F, Gaillard, JL, Ramet, JP & Humbert, G 2000 Camel (Camelus dromedarius) milk PP3: evidence for an insertion in the amino-terminal sequence of the camel milk whey protein. Biochemistry and Cell Biology 78 1926 Google Scholar
Graham, DE & Phillips, MC 1980 Proteins at liquid interfaces. V. Shear properties. Journal of Colloid Interface Science 76 240250 CrossRefGoogle Scholar
Gutiérrez-Adán, A, Maga, EA, Meade, H, Shoemaker, CF, Medrano, JF, Anderson, GB & Murray, JD 1996 Alterations of the physical characteristics of milk from transgenic mice producing bovine к-casein. Journal of Dairy Science 79 791799 Google Scholar
Hailu, Y, Hansen, EB, Seifu, E, Eshetu, M & Ipsen, R 2016 Factors influencing the gelation and rennetability of camel milk using camel chymosin. International Dairy Journal 60 6269 Google Scholar
Hamad, EM, Abdel-Rahim, EA & Romeih, EA 2011 Beneficial effect of camel milk on liver and kidneys function in diabetic sprague-dawley rats. International Journal of Dairy Science 6 190197 CrossRefGoogle Scholar
Hattem, HE, Naeim, MA, Sakr, HS & Abouel-Einin, EH 2011 A study on the effect of thermal treatments on composition and some properties of camel milk. Journal of Brewing and Distilling 2 5054 Google Scholar
Hettinga, K, van Valenberg de Vries, HS, Boeren, S, van Hooijdonk, T, van Arendonk, J & Vervoort, J 2011 The host defence proteome of human and bovine milk. PLoS ONE 6 29 Google Scholar
Hinz, K, O'Connor, PM, Huppertz, T, Ross, RP & Kelly, AL 2012 Comparison of the principal proteins in bovine, caprine, buffalo, equine and camel milk. Journal of Dairy Research 79 185191 Google Scholar
Kamau, P, Lamuka, PO & Wangoh, J 2010 Effect of lactoperoxidase-thiocyanate-hydrogen peroxide system and storage temperature on keeping quality of raw camel milk. African Journal of Food Agriculture Nutrition and Development 10 41854201 Google Scholar
Kappeler, S 1998 Compositional and Structural Analysis of Camel Milk Proteins with Emphasis on Protective Proteins. Zurich: Swiss Federal Institute of Technology Google Scholar
Kappeler, S, Farah, Z & Puhan, Z 1998 Sequence analysis of Camelus dromedarius milk caseins. Journal of Dairy Research 65 209222 Google Scholar
Kappeler, SR, Ackermann, M, Farah, Z & Puhan, Z 1999 Sequence analysis of camel (Camelus dromedarius) lactoferrin. International Dairy Journal 9 481486 Google Scholar
Kappeler, SR, Heuberger, C, Farah, Z & Puhan, Z 2004 Expression of the peptidoglycan recognition protein, PGRP, in the lactating mammary gland. Journal of Dairy Science 87 26602668 Google Scholar
Kashyap, DR, Rompca, A, Gaballa, A, Helmann, JD, Chan, J, Chang, CJ, Hozo, I, Gupta, D & Dziarski, R 2014 Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS Pathogens 10 [e1004280] DOIGoogle Scholar
Khan, JA, Kumar, P, Paramasivam, M, Yadav, RS, Sahani, MS, Sharma, S, Srinivasan, A & Singh, TP 2001 Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2·6 A resolution and structural basis of its dual role. Journal of Molecular Biology 309 751761 Google Scholar
Kherouatou, N, Nasri, M & Attia, H 2003 A Study of the dromedary milk casein micelle and its changes during acidification. Brazilian Journal of Food Technology 6 237244 Google Scholar
Konuspayeva, G, Faye, B & Loiseau, G 2009 The composition of camel milk: a meta-analysis of the literature data. Journal of Food Composition and Analysis 22 95101 CrossRefGoogle Scholar
Laleye, LC, Jobe, B & Wasesa, AAH 2008 Comparative study on heat stability and functionality of camel and bovine milk whey proteins. Journal of Dairy Science 91 45274534 CrossRefGoogle ScholarPubMed
Liu, C, Xu, Z, Gupta, D & Dziarski, R 2001 Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules. Journal of Biological Chemistry 276 3468634694 Google Scholar
Lomholt, SB & Qvist, KB 1997 Relationship between rheological properties and degree of к-casein proteolysis during renneting of milk. Journal of Dairy Research 64 541549 Google Scholar
Lopez, MB, Lomholt, SB & Qvist, KB 1998 Rheological properties and cutting time of rennet gels. Effect of pH and enzyme concentration. International Dairy Journal 8 289293 Google Scholar
Lorenzen, PC, Wernery, R, Johnson, B, Jose, S & Wernery, U 2011 Evaluation of indigenous enzyme activities in raw and pasteurised camel milk. Small Ruminant Research 97 7982 Google Scholar
Malacarne, M, Martuzzi, F, Summer, A & Mariani, P 2002 Protein and fat composition of mare's milk: some nutritional remarks with reference to human and cow's milk. International Dairy Journal 12 869877 Google Scholar
Meena, S, Rajput, YS, Pandey, AK, Sharma, R & Singh, R 2016 Camel milk ameliorates hyperglycaemia and oxidative damage in type-1 diabetic experimental rats. Journal of Dairy Research 83 412419 Google Scholar
Mellema, M, Walstra, P, Van Opheusden, JH & Van Vliet, T 2002 Effects of structural rearrangements on the rheology of rennet-induced casein particle gels. Advances in Colloid and Interface Science 98 2550 CrossRefGoogle ScholarPubMed
Merin, U, Bernstein, S, Bloch-Damti, A, Yagil, R, van Creveld, C, Lindner, P & Gollop, N 2001 A comparative study of milk serum proteins in camel (Camelus dromedarius) and bovine colostrum. Livestock Production Science 67 297301 Google Scholar
Moslehishad, M, Ehsani, MR, Salami, M, Mirdamadi, S, Ezzatpanah, H, Naslaji, AN & Moosavi-Movahedi, AA 2013 The comparative assessment of ACE-inhibitory and antioxidant activities of peptide fractions obtained from fermented camel and bovine milk by Lactobacillus rhamnosus PTCC 1637. International Dairy Journal 29 8287 Google Scholar
Panyam, D & Kilara, A 1996 Enhancing the functionality of food proteins by enzymatic modification. Trends Food Science and Technology 7 120125 CrossRefGoogle Scholar
Paulsson, M, Hegg, PO & Castberg, HB 1985 Thermal stability of whey proteins studied by differential scanning calorimetry. Thermochimica Acta 95 435440 Google Scholar
Poltronieri, P, Cappello, MS & D'Urso, OF 2012 Bioactive peptides with health benefit and their differential content in whey of different origin. In Whey Types, Composition and Health Implications, pp. 153–168 (Eds Benitez RM & Ortero GM). NY, USA: Nova Publisher, Hauppauge Google Scholar
Ramet, JP 2001 The Technology of Making Cheese from Camel Milk (Camelus dromedarius), Animal Production and Health, No. 113. Food and Agriculture Organization of the United Nations, RomeGoogle Scholar
Saadaoui, B, Henry, C, Khorchani, T, Mars, M, Martin, P & Cebo, C 2013 Proteomics of the milk fat globule membrane from Camelus dromedarius . Proteomics 13 11801184 Google Scholar
Salami, M, Moosavi-Movahedi, AA, Moosavi-Movahedi, F, Ehsani, MR, Yousefi, R, Farhadi, M, Niasari-Naslaji, A, Saboury, AA, Chobert, JM & Haertlé, T 2011 Biological activity of camel milk casein following enzymatic digestion. Journal of Dairy Research 78 471478 Google Scholar
Saliha, SAZ, Dalila, A, Chahra, S, Saliha, BH & Abderrahmane, M 2013 Separation and characterization of major milk proteins from Algerian Dromedary (Camelus dromedarius). Emirates Journal of Food and Agriculture 25 283290 Google Scholar
Salmen, SH, Abu-Tarboush, HM, Al-Saleh, AA & Metwalli, AA 2012 Amino acids content and electrophoretic profile of camel milk casein from different camel breeds in Saudi Arabia. Saudi Journal of Biological Sciences 19 177183 CrossRefGoogle ScholarPubMed
Salwa, MQ & Lina, AFK 2010 Antigenotoxic and anticytotoxic effect of camel milk in mice treated with cisplatin. Saudi Journal of Biological Science 17 159166 Google Scholar
Shamsia, SM 2009 Nutritional and therapeutic properties of camel and human milks. International Journal of Genetics and Molecular Biology 1 5258 Google Scholar
Sharma, P, Dube, D, Sinha, M, Yadav, S, Kaur, P, Sharma, S & Singh, TP 2013a Structural insights into the dual strategy of recognition by peptidoglycan recognition protein, PGRP-S: structure of the ternary complex of PGRP-S with lipopolysaccharide and stearic acid. PLoS ONE 8 18 Google Scholar
Sharma, S, Singh, AK, Kaushik, S, Sinha, M, Singh, RP, Sharma, P, Sirohi, H, Kaur, P & Singh, TP 2013b Lactoperoxidase: structural insights into the function, ligand binding and inhibition. International Journal of Biochemistry and Molecular Biology 4 108128 Google Scholar
Sharma, S, Sinha, M, Kaushik, S, Kaur, P & Singh, TP 2013c C-lobe of lactoferrin: the whole story of the half-molecule. Biochemistry Research International 2013 18 Google Scholar
Shori, AB 2015 Camel milk as a potential therapy for controlling diabetes and its complications: a review of in vivo studies. Journal of Food and Drug Analysis 23 609618 Google Scholar
Tayefi-Nasrabadi, H, Hoseinpour-fayzi, MA & Mohasseli, M 2011 Effect of heat treatment on lactoperoxidase activity in camel milk: a comparison with bovine lactoperoxidase. Small Ruminant Research 99 187190 Google Scholar
Wangoh, J, Farah, Z & Puhan, Z 1998 Iso-electric focusing of camel milk proteins. International Dairy Journal 8 617621 Google Scholar
Wu, H, Guang, X, Al-Fageeh, MB, Cao, J, Pan, S, Zhou, H, Zhang, L, Abutarboush, MH, Xing, Y, Xie, Z, Alshanqeeti, AS, Zhang, Y, Yao, Q, Al-Shomrani, BM, Zhang, D, Li, J, Manee, MM, Yang, Z, Yang, L, Liu, Y, Zhang, J, Altammami, MA, Wang, S, Yu, L, Zhang, W, Liu, S, Ba, L, Liu, C, Yang, X, Meng, F, Wang, S, Li, L, Li, E, Li, X, Wu, K, Zhang, S, Wang, J, Yin, Y, Yang, H, Al-Swailem, AM & Wang, J 2014 Camelid genomes reveal evolution and adaptation to desert environments. Nature Communications 5 5188 Google Scholar