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Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice

Published online by Cambridge University Press:  22 May 2018

Houda Hamed ,
Manel Gargouri ,
Salha Boulila ,
Fatma Chaari ,
Ferdaws Ghrab ,
Rim Kallel ,
Zied Ghannoudi ,
Tahia Boudawara ,
Semia Chaabouni  and
Abdelfattah El Feki
...Show all authors
Houda Hamed*
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Manel Gargouri
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Salha Boulila
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Fatma Chaari
Affiliation:
Enzyme Bioconversion Unit (UR13ES74), National School of Engineering, P.O. Box 1173-3038, Sfax University, Tunisia
Ferdaws Ghrab
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Rim Kallel
Affiliation:
SMS diagnostic, P.O. Box 2034, Zahra, Tunisia
Zied Ghannoudi
Affiliation:
Anatomopathology Laboratory, CHU Habib Bourguiba, Sfax, Tunisia
Tahia Boudawara
Affiliation:
SMS diagnostic, P.O. Box 2034, Zahra, Tunisia
Semia Chaabouni
Affiliation:
Enzyme Bioconversion Unit (UR13ES74), National School of Engineering, P.O. Box 1173-3038, Sfax University, Tunisia
Abdelfattah El Feki
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Ahmed Gargouri
Affiliation:
Research Unit of Toxicology, Environmental Microbiology and Health, Faculty of Science of Sfax, University of Sfax, Sfax 3064, Tunisia
*
*For correspondence; e-mail: [email protected]
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Abstract

Fermented milk is known to possess potent antioxidant activity. The present study was undertaken to assess the preventive effect of fermented camel milk (FCM) prepared using lactococcus lactis subsp. cremoris against CCl4 induced kidney damage in mice. Nephrotoxicity was induced in mice by a single dose of CCl4 (10 ml/kg 0·3% olive oil, ip). Female mice were pretreated daily with FCM for 15 d. Renal damage was associated with an increase in oxidative stress parameters (lipid peroxidation, protein carbonyl and changes in antioxidant enzyme activities and non-enzymatic antioxidant) and nephropathology markers.

The renal injury induced by CCl4 was confirmed by the histological study of the CCl4-intoxicated mice. Pretreatment with FCM significantly prevented renal dysfunction by reducing oxidative stress, while mice recovered normal kidney histology. Moreover, FCM prevented toxicity biomarker changes by reducing creatinine, urea, uric acid, lactate dehydrogenase (LDH) and electrolytes levels in plasma. These data indicate that FCM is efficient in inhibiting oxidative stress induced by CCl4, and suggests that the administration of this milk may be helpful in the prevention of kidney damage.

Keywords

Fermented camel milkCCl4oxidative stressmicekidney
Type
Research Article
Information
Journal of Dairy Research , Volume 85 , Issue 2 , May 2018 , pp. 251 - 256
Copyright
Copyright © Hannah Dairy Research Foundation 2018 

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Footnotes

†

Houda Hamed and Manel Gargouri contributed equally to this work

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