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Effects of dietary supplementation of pioglitazone or walnut meal on metabolic profiles and oxidative status in dairy cows with high pre-calving BCS

Published online by Cambridge University Press:  22 February 2018

Negin Jamali Emam Gheise ,
Ahmad Riasi ,
Pietro Celi  and
Ahmad Zare Shahneh
Negin Jamali Emam Gheise
Affiliation:
Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, POB: 84156-83111, Iran
Ahmad Riasi
Affiliation:
Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, POB: 84156-83111, Iran
Pietro Celi*
Affiliation:
DSM Nutritional Products, Columbia, MD, USA Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Vic. 3010, Australia
Ahmad Zare Shahneh
Affiliation:
Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran
*
*For correspondence; e-mail: [email protected]
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Abstract

This research paper addresses the hypothesis that dietary pioglitazone (PGT), as synthetic and specific ligand for PPAR-γ or walnut meal (WM) as a natural ligand for PPAR-γ, affect plasma metabolites and reduce the oxidative status in high body condition score (BCS) dairy cows (≥4 BCS). Total of 36 multiparous Holstein cows were randomly assigned to one of the dietary treatments: 1- Control (basal diet; CTR), 2- Walnut meal (9·45% walnut meal of DMI; WM), and 3- Pioglitazone (6 mg/kg BW; PGT). The experimental diets were fed from parturition time to 21 d postpartum. Results showed that the PGT supplementation increased dry matter intake (DMI) (22·95 kg/d) compared to the CTR (21·45 kg/d) and WM (21·78 kg/d) groups. Results showed that milk yield and milk composition were not affected by the experimental diets. Body condition score losses tended to be higher in the CTR group compared to the PGT and WM cows. The PGT group had higher plasma insulin compared to the CTR group (11·84 vs. 10·68 mIU/l), and WM cows had intermediate plasma insulin. The PGT cows had lower plasma non esterified fatty acid (NEFA) and tended to have lower β-hydroxy butyric acid (BHBA) than the CTR group. Feeding pioglitazone decreased plasma malondialdehyde (MDA) and increased plasma total antioxidant capacity (TAC) and superoxide dismutase (SOD) compared to the CTR and WM groups. It was concluded that dietary pioglitazone had positive effects on DMI, BCS change, blood metabolites and oxidative status in fresh dairy cows with high pre-calving BCS. The anti-oxidant effects of walnut meal were not supported by the present data.

Keywords

Pioglitazonewalnut mealblood metaboliteoxidative statusfat cow
Type
Research Article
Information
Journal of Dairy Research , Volume 85 , Issue 1 , February 2018 , pp. 16 - 22
Copyright
Copyright © Hannah Dairy Research Foundation 2018 

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References

Alasalvar, C, Shahidi, F, Ohshima, T, Wanasundara, U, Yurttas, HC, Liyanapathirana, CM & Rodrigues, FB 2003 Turkish Tombul hazelnut (Corylus avellana L.). 2. Lipid characteristics and oxidative stability. Journal of Agricultural and Food Chemistry 51 3797–3805 Google Scholar
Allen, MS, Bradford, BJ & Harvatine, KJ 2005 The cow as a model to study food intake regulation. Annual Review of Nutrition 25 523–547 Google Scholar
AOAC 2002 Official Methods of Analysis. 17th edition. Arlington, VA: Association of Official Analytical Chemists Google Scholar
Brand-Williams, W, Cuvelier, ME & Berset, C 1995 Use of a free radical method to evaluate antioxidant activity. LWT–Food Science and Technology 28 25–30 CrossRefGoogle Scholar
Banel, DK & Hu, FB 2009 Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. American Journal of Clinical Nutrition 90 56–63 Google Scholar
Bilici, M, Efe, H, Köroğlu, MA, Uydu, HA, Bekaroğlu, M & Değer, O 2001 Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. Journal of Affective Disorders 64 43–51 Google Scholar
Castillo, C, Hernandez, J, Bravo, A, Lopez-Alonso, M, Pereira, V & Benedito, J 2005 Oxidative status during late pregnancy and early lactation in dairy cows. Veterinary Journal 169 286–292 Google Scholar
Castillo, C, Hernandez, J, Valverde, I, Pereira, V, Sotillo, J, Alonso, ML & Benedito, J 2006 Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science 80 133–139 Google Scholar
Celi, P & Gabai, G 2015 Oxidant/antioxidant balance in animal nutrition and health: the role of protein oxidation. Frontiers in Veterinary Science 2 48–48 Google Scholar
Chaudhry, J, Ghosh, NN, Roy, K & Chandra, R 2007 Antihyperglycemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic rats. Life Science 80 1135–1142 Google Scholar
Clarke, SD 2000 Polyunsaturated fatty acid regulation of gene transcription: a mechanism to improve energy balance and insulin resistance. British Journal of Nutrition 83 59–66 Google Scholar
Ghoreishi, SM 2012 Feeding of pioglitazone in ruminants and its effects on ruminal fermentation, some blood parameters, dry matter intake. PhD thesis, Isfahan, Iran: Department of Animal Sciences, Isfahan University of Technology Google Scholar
Ghoreishi, SM, Rajaian, H, Sheykhzade, M, Alikhani, M, Rahmani, H, Hajipour, A, Khorvash, M & Khodaei, H 2012 Pharmacokinetics of pioglitazone, a thiazolidinedione derivative, in male Naeini (Iranian fat-tailed) sheep. Journal of Applied Animal Research 40 208–214 Google Scholar
Gumieniczek, A 2003 Effect of the new thiazolidinedione-pioglitazone on the development of oxidative stress in liver and kidney of diabetic rabbits. Life Science 74 553–562 Google Scholar
Guo, L & Tabrizchi, R 2006 Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance. Pharmacology and Therapeutics 111 145–173 CrossRefGoogle ScholarPubMed
Halliwell, B & Chirico, S 1993 Lipid peroxidation: its mechanism, measurement, and significance. American Journal of Clinical Nutrition 57 715–724 Google Scholar
Holtenius, P & Holtenius, K 2007 A model to estimate insulin sensitivity in dairy cows. ActaVeterinaria Scandinavica 49 29–31 Google Scholar
Houseknecht, KL, Cole, BM & Steele, PJ 2002 Peroxisome proliferator-activated receptor gamma (PPARγ) and its ligands: a review. Domestic Animal Endocrinology 22 1–23 Google Scholar
Jamali Emam Gheise, N, Riasi, A, Zareh shahneh, A, Celi, P & Ghoreishi, SM 2017 Effect of pre-calving body condition score and previous lactation on BCS change, blood metabolites, oxidative stress and milk production in Holstein dairy cows. Italian Journal of Animal Science 16 474–483 Google Scholar
Kerestes, M, Faigl, V, Kulcsár, M, Balogh, O, Földi, J, Fébel, H, Chilliard, Y & Huszenicza, G 2009 Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis. Domestic Animal Endocrinology 37 250–261 Google Scholar
Larsen, PJ, Jensen, PB, Sørensen, RV, Larsen, LK, Vrang, N, Wulff, EM & Wassermann, K 2003 Differential influences of peroxisome proliferator–activated receptorsγ and-α on food intake and energy homeostasis. Diabetes 52 2249–2259 Google Scholar
Maguire, L, O'sullivan, S, Galvin, K, O'connor, T, O'brien, N 2004 Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. International Journal of Food Science and Nutrition 55 171–178 Google Scholar
Makkar, H 2000 Quantification of tannins in tree foliage-a laboratory manual, a Joint FAO. IAEA working document, Vienna, AustriaGoogle Scholar
Makkar, HP 2003 Quantification of Tannins in Tree and Shrub Foliage: A Laboratory Manual. Springer Science & Business Media, Dordrecht, ND Google Scholar
Mir, MA, Sharma, R, Rastogi, A & Barman, K 2015 Effect of incorporation of walnut cake (Juglans regia) in concentrate mixture on degradation of dry matter, organic matter and production of microbial biomass in vitro in goat. Veterinary World 8 1172–1176 Google Scholar
Ospina, P, Nydam, D, Stokol, T & Overton, T 2010 Associations of elevated nonesterified fatty acids and β-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition dairy cattle in the northeastern United States. Journal of Dairy Science 93 1596–1603 Google Scholar
Risérus, U, Willett, WC & Hu, FB 2009 Dietary fats and prevention of type 2 diabetes. Progress in Lipid Research 48 44–51 CrossRefGoogle ScholarPubMed
Roche, JR, Friggens, NC, Kay, JK, Fisher, MW, Stafford, KJ & Berry, DP 2009 Invited review: body condition score and its association with dairy cow productivity, health, and welfare. Journal of Dairy Science 92 5769–5801 Google Scholar
SAS Institute 2001 SAS User's Guide. Statistics. Cary, NC: SAS Inst. Inc. Google Scholar
Schoenberg, KM, Perfield, KL, Farney, JK, Bradford, BJ, Boisclair, YR & Overton, TR 2011 Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-alpha and leptin, and adipose tissue gene expression. Journal of Dairy Science 94 5523–5532 Google Scholar
Schröder, UJ & Staufenbiel, R 2006 Invited review: Methods to determine body fat reserves in the dairy cow with special regard to ultrasonographic measurement of backfat thickness. Journal of Dairy Science 89 1–14 Google Scholar
Smith, K, Stebulis, S, Waldron, M & Overton, T 2007 Prepartum 2,4-thiazolidinedione alters metabolic dynamics and dry matter intake of dairy cows. Journal of Dairy Science 90 3660–3670 Google Scholar
Smith, K, Butler, W & Overton, T 2009 Effects of prepartum 2,4-thiazolidinedione on metabolism and performance in transition dairy cows. Journal of Dairy Science 92 3623–3633 Google Scholar
Tordjman, J, Chauvet, G, Quette, J, Beale, EG, Forest, C & Antoine, B 2003 Thiazolidinedione block fatty acid release by inducing glyceroneogenesis in fat cells. Journal of Biological Chemistry 278 18785–18790 Google Scholar
USDA ARS, Nutrient Data Laboratory 2012 National Nutrient Database for Standard Reference. Internet. http://www.nal.usda.gov/fnic/foodcomp/search Google Scholar
Van Soest, PV, Robertson, J & Lewis, B 1991 Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science 74 3583–3597 Google Scholar
Wu, H, Pan, A, Yu, Z, Qi, Q, Lu, L, Zhang, G, Yu, D, Zong, G, Zhou, Y & Chen, X 2010 Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. Journal of Nutrition 140 1937–1942 Google Scholar
Yilmaz, M, Bukan, N, Ayvaz, G, Karakoç, A, Törüner, F, Çakir, N & Arslan, M 2005 The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome. Human Reproduction 20 3333–3340 Google Scholar
Yousefi, AR, Kohram, H, Shahneh, AZ, Zamiri, MJ & Fouladi-Nashta, AA 2016 Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows. Theriogenology 85 1540–1548 CrossRefGoogle ScholarPubMed
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