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Effect of serotonin on the motility of smooth muscles in teats of lactating cows

Published online by Cambridge University Press:  01 June 2009

Georgette Vandeputte-Van Messom ,
Christian Burvenich  and
Georges Peeters
Georgette Vandeputte-Van Messom
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
Christian Burvenich
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
Georges Peeters
Affiliation:
Department of Physiology, Faculty of Veterinary Medicine, University of Ghent, Casinoplein 24, B-9000 Ghent, Belgium
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Summary

The effects of serotonin, injected into one udder artery, on teat smooth muscle function were investigated in four lactating cows. Motility of longitudinal smooth muscles was recorded by a plethysmographic technique, and sphincter function by measuring milk leakage from the full udder. Serotonin (40, 120 and 360 μg) activated teat muscle tonicity and reduced the volume of milk leakage. The effects on longitudinal smooth muscles were reduced by mianserin and ketanserin (0·375, 1·5 and 6 mg) and by methysergide (1·5 mg). These blocking substances were also effective (0·2, 0·6 and 1·8 mg respectively) in antagonizing the inhibiting action of serotonin on milk leakage. It is suggested that serotonin effects are mediated by receptors of the S2-type.

Type
Original Articles
Information
Journal of Dairy Research , Volume 52 , Issue 3 , August 1985 , pp. 347 - 353
Copyright
Copyright © Proprietors of Journal of Dairy Research 1985

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References

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