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The effect of lα-hydroxycholecalciferol on the concentrations of calcium, magnesium and inorganic phosphate in the plasma of parturient cows

Published online by Cambridge University Press:  01 June 2009

Fernando Wittwer  and
Edwin J. H. Ford
Fernando Wittwer
Affiliation:
Department of Veterinary Clinical Studies, University of Liverpool, Leahurst, Neston, Merseyside, L64 7TE
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Summary

135 Cows which were expected to produce a second or subsequent calf within 4–11 d received an intramuscular injection of 500 μg lα-hydroxycholecalciferol (lα-OHD3). In those animals in which the interval between injection and calving was at least 7 d there was, at 7 d after injection of lα-OHD3, a significant increase (P < 0.001) in the blood plasma concentrations of Ca and Pi and a significant reduction (P < 0.05) in that of Mg, compared with those in control animals. Within 24 h of calving there was a significant increase (P < 0.001) in the concentration of Pi but no change in Ca or Mg compared with pre-injection levels, whilst the control animals showed a significant fall (P < 0.001) in the concentration of Ca and a rise in those of Pi (P < 0.001) and Mg (P < 0.05). There was a significant reduction (P < 0.001) in the number of animals with hypocalcaemia (defined as a plasma Ca concentration <1.9 mmol/1) in all animals injected with lα-OHD3; this reduction was particularly marked when the interval between injection and calving was between 1 and 8 d. The previously reported reduction in the incidence of clinical milk fever is considered to be a consequence of the effect of lα-OHD3 on the concentration of Ca in plasma.

Type
Original Articles
Information
Journal of Dairy Research , Volume 47 , Issue 2 , June 1980 , pp. 177 - 183
Copyright
Copyright © Proprietors of Journal of Dairy Research 1980

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References

REFERENCES

Barlet, J. P. (1975). Comptes Rendus Hebdomadaires des Séances de l' Académic de Sciences D 281, 1497–1500.Google Scholar
Barlet, J. P. (1977). Annales de Biologie animate, Biochimie, Biophysique 17, 363–371.CrossRefGoogle Scholar
Corbett, J. L. (1969). In Science of nutrition of farm livestock II, 593–644 (Ed. Cuthbertson, D.) Oxford: Pergamon Press.Google Scholar
Davies, D. C., Allen, W. M., Hoare, M. N., Pott, J. M., Riley, C. J., Sansom, B. F., Stenton, J. R. & Vagg, M. J. (1978). Veterinary Record 102, 440–442.CrossRefGoogle Scholar
Deluca, H. F. (1974). Federation Proceedings 33, 2211–2219.Google Scholar
Fiske, C. H. & Subbarow, Y. (1925). Journal of Biological Chemistry 66, 375–400.CrossRefGoogle Scholar
Haussler, M. R., Zerwekh, J. E., Hesse, R. H., Rizzardo, E. & Pechet, M. M. (1973). Proceedings of the National Academy of Science 70, 2248–2252.CrossRefGoogle Scholar
Holick, M. F., Tavela, T. E., Holick, S. A., Sohnoes, H. K., Deluca, H. F. & Gallagher, B. M. (1976). Journal of Biological Chemistry 251, 1020–1024.CrossRefGoogle Scholar
Omdahl, J. L. & Deluca, H. F. (1973). Physiological Reviews 53, 327–372.CrossRefGoogle Scholar
Sachs, M., Bar, A., Cohen, R., Mazur, Y., Mayer, E. & Hurwitz, S. (1977). American Journal of Veterinary Research 38, 2039–2041.Google Scholar
Sansom, B. F., Allen, W. M., Davies, D. C., Hoare, M. N., Stenton, J. R. & Vagg, M. J. (1976 a). Proceedings of the Third International Conference on Production Disease in Farm Animals, pp. 111–114. Wageningen: Centre for Agricultural Publishing and Documentation.Google Scholar
Sansom, B. F., Allen, W. M., Davies, D. C., Hoare, M. N., Stenton, J. R. & Vagg, M. J. (1976 b). Veterinary Record 99, 310–312.CrossRefGoogle Scholar
Sansom, B. F., Allen, W. M., Stenton, J. & Vagg, M. J. (1976 c). Reports el résumés, IX Congrés International sur les maladies du betail, Paris, p. 78.Google Scholar
Wittwer, F. G. & Ford, E. J. H. (1978). Veterinary Record 102, 442–443.CrossRefGoogle Scholar