Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-02T18:58:24.730Z Has data issue: false hasContentIssue false
  • English
  • Français

Does trans-10, cis-12 conjugated linoleic acid affect the intermediary glucose and energy expenditure of dairy cows due to repartitioning of milk component synthesis?

Published online by Cambridge University Press:  05 August 2015

Jens Benninghoff ,
Katrin Metzger-Petersen ,
Arnulf HA Tröscher  and
Karl-Heinz Südekum
Jens Benninghoff
Affiliation:
Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
Katrin Metzger-Petersen
Affiliation:
Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
Arnulf HA Tröscher
Affiliation:
BASF SE, 68623 Lampertheim, Germany
Karl-Heinz Südekum*
Affiliation:
Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
*
*For correspondence; e-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The overall goal of this study was to evaluate if intermediary energy metabolism of cows fed with trans-10, cis-12 conjugated linoleic acid (CLA) was modified such that milk-energy compounds were produced with less intermediary energy expenditure as compared to control cows. Published data on supplemented CLA were assembled. The extent was calculated to which the trans-10, cis-12 CLA isomer has an impact on glucose and energy conversion in the mammary gland by modifying glucose equivalent supply and energy required for fatty acid (FA) and fat synthesis, and if this will eventually lead to an improved glucose and energy status of CLA-supplemented high-yielding dairy cows. A possible relationship between CLA supplementation level and milk energy yield response was also studied. Calculations were conducted separately for orally and abomasally administered CLA and based on energy required for supply of glucose equivalents, i.e. lactose, glycerol and NADPH2. Further, modifications of milk FA profile due to CLA supplementation were considered when energy expenditures for FA and fat synthesis were quantified. Differences in yields between control and CLA groups were transformed into glucose energy equivalents. Only abomasal infusion (r2 = 0·31) but not oral CLA administration (r2 = 0·11) supplementation to dairy cow diets resulted in less glucose equivalent energy. Modifications of milk FA profiles also saved energy but the relationship with CLA supplementation was weaker for abomasal infusion (r2 = 0·06) than oral administration (r2 = 0·38). On average, 10 g/d of abomasally infused trans-10, cis-12 CLA saved 1·1 to 2·3 MJ net energy expressed as glucose equivalents, whereas both positive and negative values were observed when the trans-10, cis-12 CLA was fed to the cows.

This study revealed a weak to moderate dose-dependent relationship between the amount of trans-10, cis-12 CLA administered and the amount of energy in glucose equivalents and energy for the synthesis of milk fat conserved from milk ingredient synthesis. Because abomasal infusion of the trans-10, cis-12 CLA more consistently conserved energy in glucose equivalents compared with oral CLA intake, rumen protection of the fed CLA products appears incomplete. Milk fat synthesis showed an energy saving with a weak dose-dependent relationship when CLA was supplemented orally or by abomasal infusion.

Keywords

CLAenergy metabolismglucose turnoverdairy cow
Type
Research Article
Information
Journal of Dairy Research , Volume 82 , Issue 4 , November 2015 , pp. 407 - 415
Copyright
Copyright © Proprietors of Journal of Dairy Research 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bauman, DE & Davis, CL 1974 Biosynthesis of milk fat. In Lactation: A Comprehensive Treatise, vol. 2, pp. 31–75 (eds Larson, L, Smith, VR). New York, NY, USA: Academic PressGoogle Scholar
Baumgard, LH, Corl, BA, Dwyer, DA, Saebø, A & Bauman, DE 2000 Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 278 R179–R184CrossRefGoogle ScholarPubMed
Baumgard, LH, Sangster, JK & Bauman, DE 2001 Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). Journal of Nutrition 131 1764–1769CrossRefGoogle ScholarPubMed
Baumgard, LH, Matitashvili, E, Corl, BA, Dwyer, DA & Bauman, DE 2002 Trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows. Journal of Dairy Science 85 2155–2163CrossRefGoogle ScholarPubMed
Bell, JA & Kennelly, JJ 2003 Short communication: postruminal infusion of conjugated linoleic acids negatively impacts milk synthesis in Holstein cows. Journal of Dairy Science 86 1321–1324CrossRefGoogle ScholarPubMed
Bergner, H & Hoffmann, L 1996 Bioenergetik und Stoffwechselproduktion landwirtschaftlicher Nutztiere. Amsterdam, The Netherlands: Harward Academic PublishersGoogle Scholar
Bernal-Santos, G, Perfield, JW II, Barbano, DM, Bauman, DE & Overton, TR 2003 Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation. Journal of Dairy Science 86 3218–3228CrossRefGoogle ScholarPubMed
Bernard, L, Leroux, C & Chilliard, Y 2006 Characterisation and nutritional regulation of the main lipogenic genes in the ruminant lactating mammary gland. In Ruminant Physiology, Digestion, Metabolism, and Impact of Nutrition on Gene Expression, Immunology and Stress, pp. 295–326 (eds Sejrsen, K, Hvelplund, T, Nielsen, MO). Wageningen, The Netherlands: Wageningen Academic PublishersCrossRefGoogle Scholar
Castañeda-Gutiérrez, E, Benefield, BC, de Veth, MJ, Santos, NR, Gilbert, RO, Butler, WR & Bauman, DE 2007 Evaluation of the mechanism of action of conjugated linoleic acid isomers on reproduction in dairy cows. Journal of Dairy Science 90 4253–4264CrossRefGoogle ScholarPubMed
Castañeda-Gutiérrez, E, Overton, TR, Butler, WR & Bauman, DE 2005 Dietary supplements of two doses of calcium salts of conjugated linoleic acid during the transition period and early lactation. Journal of Dairy Science 88 1078–1089CrossRefGoogle ScholarPubMed
Chouinard, PY, Corneau, L, Barbano, DM, Metzger, LE & Bauman, DE 1999 Conjugated linoleic acids alter milk fatty acid composition and inhibit milk fat secretion in dairy cows. Journal of Nutrition 129 1579–1584CrossRefGoogle ScholarPubMed
Davis, SR & Collier, RJ 1985 Mammary blood flow and regulation of substrate supply for milk synthesis. Journal of Dairy Science 68 1041–1058CrossRefGoogle ScholarPubMed
De Veth, MJ, Griinari, JM, Pfeiffer, A-M & Bauman, DE 2004 Effect of CLA on milk fat synthesis in dairy cows: comparison of inhibition by methyl esters and free fatty acids, and relationships among studies. Lipids 39 365–372CrossRefGoogle ScholarPubMed
De Veth, MJ, Gulati, SK, Luchini, ND & Bauman, DE 2005 Comparison of calcium salts and formaldehyde-protected conjugated linoleic acid in inducing milk fat depression. Journal of Dairy Science 88 1685–1693CrossRefGoogle ScholarPubMed
De Veth, MJ, Castañeda-Gutiérrez, E, Dwyer, DA, Pfeiffer, AM, Putnam, DE & Bauman, DE 2006 Response to conjugated linoleic acid in dairy cows differing in energy and protein status. Journal of Dairy Science 89 4620–4631CrossRefGoogle ScholarPubMed
De Veth, MJ, Bauman, DE, Koch, W, Mann, GE, Pfeiffer, AM & Butler, WR 2009 Efficacy of conjugated linoleic acid for improving reproduction: a multi-study analysis in early-lactation dairy cows. Journal of Dairy Science 92 2662–2669CrossRefGoogle ScholarPubMed
Gervais, R, Spratt, R, Líonard, M & Chouinard, PY 2005 Lactation response of cows to different levels of ruminally inert conjugated linoleic acids under commercial conditions. Canadian Journal of Animal Science 85 231–242CrossRefGoogle Scholar
Gervais, R, McFadden, JW, Lengi, AJ, Corl, BA & Chouinard, PY 2009 Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows. Journal of Dairy Science 92 5167–5177CrossRefGoogle Scholar
Giesy, JG, McGuire, MA, Shafii, B & Hanson, TW 2002 Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation Holstein cows. Journal of Dairy Science 85 2023–2029CrossRefGoogle ScholarPubMed
Gruber, L, Susenbeth, A, Schwarz, FJ, Fischer, B, Spiekers, H, Steingass, H, Meyer, U, Chassot, A, Jilg, T & Obermaier, A 2008 Bewertung des NEL-Systems und Schätzung des Energiebedarfs von Milchkühen auf der Basis von umfangreichen Fütterungsversuchen in Deutschland, Österreich und der Schweiz. In 35th Viehwirtschaftliche Fachtagung; 2008 April 9–10, pp. 47–57 (ed LFZ Raumberg-Gumpenstein). Irdning, Austria: LFZ Raumberg-GumpensteinGoogle Scholar
Han, LQ, Pang, K, Li, HJ, Zhu, SB, Wang, LF, Wang, YB, Yang, GQ & Yang, GY 2012 Conjugated linoleic acid-induced milk fat reduction associated with depressed expression of lipogenic genes in lactating Holstein mammary glands. Genetics and Molecular Research 11 4754–4764CrossRefGoogle ScholarPubMed
Harvatine, KJ, Perfield, JW II & Bauman, DE 2009 Expression of enzymes and key regulators of lipid synthesis is upregulated in adipose tissue during CLA-induced milk fat depression in dairy cows. Journal of Nutrition 139 849–854CrossRefGoogle ScholarPubMed
Hötger, K, Hammon, HM, Weber, C, Görs, S, Tröscher, A, Bruckmaier, RM & Metges, CC 2013 Supplementation of conjugated linoleic acid in dairy cows reduces endogenous glucose production during early lactation. Journal of Dairy Science 96 2258–2270CrossRefGoogle ScholarPubMed
Huang, Y, Schoonmaker, JP, Bradford, BJ & Beitz, DC 2008 Response of milk fatty acid composition to dietary supplementation of soy oil, conjugated linoleic acid, or both. Journal of Dairy Science 91 260–270CrossRefGoogle ScholarPubMed
Hussein, M, Harvatine, KH, Weerasinghe, WMPB, Sinclair, LA & Bauman, DE 2013 Conjugated linoleic acid-induced milk fat depression in lactating ewes is accompanied by reduced expression of mammary genes involved in lipid synthesis. Journal of Dairy Science 96 3825–3834CrossRefGoogle ScholarPubMed
Hutchinson, IA, de Veth, M, Stanton, C, Dewhurst, RJ, Lonergan, P, Evans, ACO & Butler, ST 2011 Effects of lipid-encapsulated conjugated linoleic acid supplementation on milk production, bioenergetics status and indicators of reproductive performance in lactating dairy cows. Journal of Dairy Research 78 308–317CrossRefGoogle ScholarPubMed
Hutchinson, IA, Hennessy, AA, Dewhurst, RJ, Evans, ACO, Lonergan, P & Butler, ST 2012 The effect of strategic supplementation with trans-10, cis-12 conjugated linoleic acid on the milk production, estrous cycle characteristics, and reproductive performance of lactating dairy cattle. Journal of Dairy Science 95 2442–2451CrossRefGoogle ScholarPubMed
Kay, JK, Mackle, TR, Bauman, DE, Thomson, NA & Baumgard, LH 2007 Effects of supplement containing trans-10, cis-12 conjugated linoleic acid on bioenergetic and milk production parameters in grazing dairy cows offered ad libitum or restricted pasture. Journal of Dairy Science 90 721–730CrossRefGoogle ScholarPubMed
Kramer, R, Wolf, S, Petri, T, von Soosten, D, Dänicke, S, Weber, E-M, Zimmer, R, Rehage, J & Jahreis, G 2014 A commonly used rumen-protected conjugated linoleic acid supplement marginally affects fatty acid distribution of body tissues and gene expression of mammary gland in heifers during early lactation. Lipids in Health and Disease 12 96–108CrossRefGoogle Scholar
Liermann, T, Pfeiffer, A-M & Schwarz, FJ 2008 Effects and post-effects on performance and metabolic parameters of early lactation dairy cows to dietary rumen-protected fat. Proceedings of the Society of Nutrition Physiology 17 30Google Scholar
Loor, JJ & Herbein, JH 2003 Reduced fatty acid synthesis and desaturation due to exogenous trans10, cis12-CLA in cows fed oleic or linoleic oil. Journal of Dairy Science 86 1354–1369CrossRefGoogle ScholarPubMed
Mackle, TR, Kay, JK, Auldist, MJ, McGibbon, AKH, Philpott, BA, Baumgard, LH & Bauman, DE 2003 Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. Journal of Dairy Science 86 644–652CrossRefGoogle ScholarPubMed
Maxin, G, Glasser, F & Rulquin, H 2010 Additive effects of trans-10, cis-12 conjugated linoleic acid and propionic acid on milk fat content and composition in dairy cows. Journal of Dairy Research 77 295–301CrossRefGoogle ScholarPubMed
Maxin, G, Glasser, F, Hurtaud, C, Peyraud, JL & Rulquin, H 2011 Combined effects of trans-10, cis-12 conjugated linoleic acid, propionate, and acetate on milk fat yield and composition in dairy cows. Journal of Dairy Science 94 2051–2059CrossRefGoogle ScholarPubMed
Medeiros, SR, Oliveira, DE, Aroeira, LJM, McGuire, MA, Bauman, DE & Lanna, DPD 2010 Effects of dietary supplementation of rumen-protected conjugated linoleic acid to grazing cows in early lactation. Journal of Dairy Science 93 1126–1137CrossRefGoogle ScholarPubMed
Metzger-Petersen, K 2013 Supplementation of a rumen-protected conjugated linoleic acid mixture (cis-9, trans-11; trans-10, cis-12) to early lactation dairy cows – effects on feed intake and performance. Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, GermanyGoogle Scholar
Moallem, U, Lehrer, H, Zachut, M, Livshitz, L & Yacoby, S 2010 Production performance and pattern of milk fat depression of high-yielding dairy cows supplemented with encapsulated conjugated linoleic acid. Animal 4 641–652CrossRefGoogle ScholarPubMed
Moore, CE, Haflinger, HC III, Mendivil, OB, Sanders, SR, Bauman, DE & Baumgard, LH 2004 Increasing amounts of conjugated linoleic acid (CLA) progressively reduces milk fat synthesis immediately postpartum. Journal of Dairy Science 87 1886–1895CrossRefGoogle ScholarPubMed
Moore, CE, Kay, JK, Collier, RJ, VanBaale, MJ & Baumgard, LH 2005 Effect of supplemental conjugated linoleic acids on heat-stressed Brown Swiss and Holstein cows. Journal of Dairy Science 88 1732–1740CrossRefGoogle ScholarPubMed
Odens, LJ, Burgos, R, Innocenti, M, VanBaale, MJ & Baumgard, LH 2007 Effects of varying doses of supplemental conjugated linoleic acid on production and energetic variables during the transition period. Journal of Dairy Science 90 293–305CrossRefGoogle ScholarPubMed
Onnen-Lübben, EF 2009 Einfluss einer gestaffelten CLA-Supplementation auf die Gelbkörperfunktion während des Zyklus und der frühen Grävidität bei Hochleistungsmilchkühen. Dissertation, Tierärztliche Hochschule Hannover, GermanyGoogle Scholar
Pappritz, J, Meyer, U, Kramer, R, Weber, EM, Jahreis, G, Rehage, J, Flachowsky, G & Dänicke, S 2011 Effects of long-term supplementation of dairy cow diets with rumen-protected conjugated linoleic acids (CLA) on performance, metabolic parameters and fatty acid profile in milk fat. Archives of Animal Nutrition 65 89–107CrossRefGoogle ScholarPubMed
Perfield, JW II, Bernal-Santos, G, Overton, TR & Bauman, DE 2002 Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation. Journal of Dairy Science 85 2609–2617CrossRefGoogle ScholarPubMed
Perfield, JW II, Lock, AL, Pfeiffer, AM & Bauman, DE 2004a Effects of amide-protected and lipid-encapsulated conjugated linoleic acid (CLA) supplements on milk fat synthesis. Journal of Dairy Science 87 3010–3016CrossRefGoogle ScholarPubMed
Perfield, JW II, Saebø, A & Bauman, DE 2004b Use of Conjugated Linoleic Acid (CLA) Enrichments to examine the effects of trans-8, cis-10 CLA, and cis-11, trans-13 CLA on milk-fat synthesis. Journal of Dairy Science 87 1196–1202CrossRefGoogle ScholarPubMed
Perfield, JW II, Delmonte, P, Lock, AL, Yurawecz, MP & Bauman, DE 2006 Trans-10, trans-12 conjugated linoleic acid does not affect milk fat yield but reduces Δ9-desaturase index in dairy cows. Journal of Dairy Science 89 2559–2566CrossRefGoogle Scholar
Perfield, JW II, Lock, AL, Griinari, JM, Saebø, A, Delmonte, P, Dwyer, DA & Bauman, DE 2007 Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cows. Journal of Dairy Science 90 2211–2218CrossRefGoogle ScholarPubMed
Petzold, M 2014 Investigations on the effects of conjugated linoleic acids and dietary concentrate proportion on performance and various physiological parameters of periparturient dairy cows and their calves. Dissertation, Martin-Luther-Universität, Halle-Wittenberg, GermanyGoogle Scholar
Piamphon, N, Wachirapakorn, C, Wanapat, M & Navanukraw, C 2009 Effects of protected conjugated linoleic acid supplementation on milk fatty acid in dairy cows. Asian-Australasian Journal of Animal Sciences 22 49–56CrossRefGoogle Scholar
Piperova, LS, Moallem, U, Teter, BB, Sampugna, J, Yurawecz, MP, Morehouse, KM, Luchini, D & Erdman, RA 2004 Changes in milk fat in response to dietary supplementation with calcium salts of trans-18:1 or conjugated linoleic fatty acids in lactating dairy cows. Journal of Dairy Science 87 3836–3844CrossRefGoogle ScholarPubMed
SAS 2004 SAS/STAT® 9·1 User's Guide. Cary, NC, USA: SAS Institute Inc.Google Scholar
Saremi, B, Winand, S, Friedrichs, P, Kinoshita, A, Rehage, J, Dänicke, S, Häussler, S, Breves, G, Mielenz, M & Sauerwein, H 2014 Longitudinal profiling of the tissue-specific expression of genes related with insulin sensitivity in dairy cows during lactation focusing on different fat depots. PLoS One 9 e86211CrossRefGoogle ScholarPubMed
Schauff, DJ, Clark, JH & Drackley, JK 1992 Effects of feeding lactating dairy cows diets containing extruded soybeans and calcium salts of long-chain fatty acids. Journal of Dairy Science 75 3003–3019CrossRefGoogle ScholarPubMed
Selberg, KT, Lowe, AC, Staples, CR, Luchini, ND & Badinga, L 2004 Production and metabolic responses of periparturient Holstein cows to dietary conjugated linoleic acid and trans-octadecenoic acids. Journal of Dairy Science 87 158–168CrossRefGoogle ScholarPubMed
Shingfield, KJ, Saebø, A, Saebø, P-C, Toivonen, V & Griinari, JM 2009 Effect of abomasal infusions of a mixture of octadecenoic acids on milk fat synthesis in lactating cows. Journal of Dairy Science 92 4317–4329CrossRefGoogle ScholarPubMed
Sigl, T, Schlamberger, G, Kienberger, H, Wiedemann, S, Meyer, HHD & Kaske, M 2010 Rumen-protected conjugated linoleic acid supplementation to dairy cows in late pregnancy and early lactation: effects on milk composition, milk yield, blood metabolites and gene expression in liver. Acta Veterinaria Scandinavica 52 16–23CrossRefGoogle ScholarPubMed
Stoop, WM, van Arendonk, JAM, Heck, JML, van Valenberg, HJF & Bovenhuis, H 2008 Genetic parameters for major milk fatty acids and milk production traits of Dutch Holstein-Friesians. Journal of Dairy Science 91 385–394CrossRefGoogle ScholarPubMed
van Straalen, WM 2004 Effect of rumen stable CLA on feed intake, milk production, and -composition, energy balance, and fertility and health parameters with dairy cows in start lactation. Report nr. 658. Schothorst Feed Research, Lelystad, The NetherlandsGoogle Scholar
von Soosten, D, Meyer, U, Weber, EM, Rehage, J, Flachowsky, G & Dänicke, S 2011 Effect of trans-10, cis-12 conjugated linoleic acid on performance, adipose depot weights, and liver weight in early-lactation dairy cows. Journal of Dairy Science 94 2859–2870CrossRefGoogle ScholarPubMed
von Soosten, D, Meyer, U, Piechotta, M, Flachowsky, G & Dänicke, S 2012 Effect of conjugated linoleic acid supplementation on body composition, body fat mobilization, protein accretion, and energy utilization in early lactation dairy cows. Journal of Dairy Science 95 1222–1239CrossRefGoogle ScholarPubMed
Viswanadha, S, Giesy, JG, Hanson, TW & McGuire, MA 2003 Dose response of milk fat to intravenous administration of the trans-10, cis-12 isomer of conjugated linoleic acid. Journal of Dairy Science 86 3229–3236CrossRefGoogle ScholarPubMed
Vyas, D, Moallem, U, Teter, BB, Fardin-Kia, ARK & Erdman, RA 2013 Milk fat responses to butterfat infusion during conjugated linoleic acid-induced milk fat depression in lactating dairy cows. Journal of Dairy Science 96 2387–2399CrossRefGoogle ScholarPubMed
Waghorn, GC & Baldwin, RL 1984 Model of metabolite flux within mammary gland of the lactating cow. Journal of Dairy Science 67 531–544CrossRefGoogle ScholarPubMed