Hostname: page-component-745bb68f8f-f46jp Total loading time: 0 Render date: 2025-01-11T22:20:57.519Z Has data issue: false hasContentIssue false
  • English
  • Français

Cardiovascular responses and mammary substrate uptake in Jersey cows treated with pituitary-derived growth hormone during late lactation

Published online by Cambridge University Press:  01 June 2009

Frances M. Fullerton ,
Ivan R. Fleet ,
R. Brian Heap ,
Ian C. Hart  and
T. Ben Mepham
Frances M. Fullerton
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
Ivan R. Fleet
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
R. Brian Heap
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
Ian C. Hart
Affiliation:
AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, UK
T. Ben Mepham
Affiliation:
University of Nottingham, Department of Physiology and Environmental Science, Faculty of Agricultural Science, Sutton Bonington, Loughborough LE12 5RD, UK
Get access Rights & Permissions [Opens in a new window]

Summary

Pituitary-derived bovine growth hormone (bGH) was administered to Jersey cows during late lactation for 7 d. Milk yield increased significantly during treatment and by a maximum of 49·6% on d 7. The magnitude of the increase was similar to that of mammary plasma flow (47·8±18·3%) over the same period. By 15–21 d after treatment, both variables had returned to pretreatment values. With respect to milk composition, bGH had negligible effect on lactose and fat concentrations but there were significant decreases in protein, sodium and chloride. Arterial plasma concentrations of bGH increased substantially during treatment, but the associated rise in insulin was not statistically significant. Haematocrit decreased significantly, the lowest value being recorded 3 d after bGH treatment ceased. Mammary respiratory quotient fell progressively after the start of bGH treatment and reached the lowest recorded value 3 d after treatment ceased (62·2 ± 7·3% of pretreatment value). Glucose and acetate uptake by the mammary gland increased significantly during treatment, increase in glucose uptake being due both to a greater arterio-venous difference and to mammary plasma flow. There was strong evidence that the acute response in increased milk yield was associated with multiple effects in terms of mammary plasma flow and metabolism, as well as haematocrit changes indicative of increased plasma volume.

Type
Original Articles
Information
Journal of Dairy Research , Volume 56 , Issue 1 , February 1989 , pp. 27 - 35
Copyright
Copyright © Proprietors of Journal of Dairy Research 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Annison, E. F. 1983 Metabolic utilization by the ruminant mammary gland, In Biochemistry of Lactation pp. 399–436 (Ed. Mepham, T. B.). London: ElsevierGoogle Scholar
Bauman, D. E. & Elliot, J. M. 1983 Control of nutrient partitioning in lactating ruminants. In Biochemistry of Lactation pp. 437–468 (Ed. Mepham, T. B.). London: ElsevierGoogle Scholar
Bauman, D. E., Eppard, P. J., DeGeeter, M. J. & Lanza, G. M. 1985 Responses of high-producing dairy cows to long-term treatment with pituitary somatotropin and recombinant somatotropin. Journal of Dairy Science 68 1352–1362CrossRefGoogle ScholarPubMed
Bickerstaffe, R., Annison, E. F. & Linzell, J. L. 1974 The metabolism of glucose, acetate, lipids and amino acids in lactating dairy cows. Journal of Agricultural Science 82 71–85CrossRefGoogle Scholar
Bines, J. A., Hart, I. C. & Morant, S. V. 1983 Endocrine control of energy metabolism in the cow: diurnal variations in the concentrations of hormones and metabolites in the blood plasma of beef and dairy cows. Hormone and Metabolic Research 15 330–334CrossRefGoogle ScholarPubMed
Bitman, J., Wood, D. L., Tyrrell, H. F., Bauman, D. E., Peel, C. J., Brown, A. C. G. & Reynolds, P. J. 1984 Blood and milk lipid responses induced by growth hormone administration in lactating cows. Journal of Dairy Science 67 2873–2880CrossRefGoogle ScholarPubMed
Davis, S. R., Collier, R. J., McNamara, J. P., Head, H. H., Croom, W. J. & Wilcox, C. J. 1988 b Effects of thyroxine and growth hormone treatment of dairy cows on mammary uptake of glucose, oxygen and other milk fat precursors. Journal of Animal Science 66 80–89CrossRefGoogle ScholarPubMed
Davis, S. R., Collier, R. J., McNamara, J. P., Head, H. H. & Sussman, W. 1988 a Effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. Journal of Animal Science 66 70–79CrossRefGoogle ScholarPubMed
Davis, S. R., Gluckman, P. D., Hart, I. C. & Henderson, H. V. 1987 Effects of injecting growth hormone or thyroxine on milk production and blood plasma concentrations of insulin-like growth factors I and II in dairy cows. Journal of Endocrinology 114 17–24CrossRefGoogle ScholarPubMed
Eppard, P. J., Bauman, D. E., Bitman, J., Wood, D. L., Akers, R. M. & House, W. A. 1985 Effect of dose of bovine growth hormone on milk composition: α-lactalbumin, fatty acids, and mineral elements. Journal of Dairy Science 68 3047–3054CrossRefGoogle ScholarPubMed
Fleet, I. R., Davis, A., Fullerton, F. M., Pendelton, J. W., Mepham, T. B. & Heap, R. B. 1986 Cardiovascular and renal responses to bovine growth hormone in the lactating sheep. Journal of Endocrinology 108 (suppl.) 149Google Scholar
Fleet, I. R., Linzell, J. L. & Peaker, M. 1972 The use of an auto-analyzer for the rapid analysis of milk constituents affected by subclinical mastitis. British Veterinary Journal 128 297–300CrossRefGoogle Scholar
Fleet, I. R. & Mepham, T. B. 1983 Physiological methods used in the study of mammary substrate utilization in ruminants. In Biochemistry of Lactation pp. 469–491 (Ed. Mepham, T. B.). London: ElsevierGoogle Scholar
Fleet, I. R. & Mepham, T. B. 1985 Mammary uptake of amino acids and glucose throughout lactation in Friesland sheep. Journal of Dairy Research 52 229–237CrossRefGoogle ScholarPubMed
Hart, I. C., Chadwick, P. M. E., James, S. & Simmonds, A. D. 1985 Effect of intravenous bovine growth hormone or human pancreatic growth hormone-releasing factor on milk production and plasma hormones and metabolites in sheep. Journal of Endocrinology 105 189–196CrossRefGoogle ScholarPubMed
Hart, I. C., Flux, D. S., Andrews, P. & McNeilly, A. S. 1975 Radio-immunoassay for ovine and caprine growth hormone: its application to the measurement of basal circulating levels of growth hormone in the goat. Hormone and Metabolic. Research 7 35–40CrossRefGoogle Scholar
Linzell, J. L. 1966 Measurement of venous flow by continuous thermodilution and its application to measurement of mammary blood flow in the goat. Circulation Research 43 745–754CrossRefGoogle Scholar
Linzell, J. L. & Fleet, I. R. 1969 Accuracy of the micromethod of estimating milk fat concentration by highspeed centrifugation in capillary tubes. Journal of Dairy Science 52 1685–1687CrossRefGoogle Scholar
Machlin, L. J. 1973 Effect of growth hormone on milk production and feed utilization in dairy cows. Journal of Dairy Science 56 575–580CrossRefGoogle ScholarPubMed
McDowell, G. H., Gooden, J. M., Leenanuruksa, D., Jois, M. & English, A. W. 1987 Effects of exogenous growth hormone on milk production and nutrient uptake by muscle and mammary tissues of dairy cows in mid-lactation. Australian Journal of Biological Sciences 40 295–306CrossRefGoogle ScholarPubMed
Mepham, T. B., Lawrence, S. E., Peters, A. R. & Hart, I. C. 1984 Effects of exogenous growth hormone on mammary function in lactating goats. Hormone and Metabolic Research 16 248–253CrossRefGoogle ScholarPubMed
Peel, C. J., Fronk, T. J., Bauman, D. E. & Gorewit, R. C. 1983 Effect of exogenous growth hormone in early and late lactation on lactational performance of dairy cows. Journal of Dairy Science 66 776–782CrossRefGoogle ScholarPubMed
Pethick, D. W., Lindsay, D. B., Barker, P. J. & Northrop, A. J. 1981 Acetate supply and utilization by the tissues of sheep in vivo. British Journal of Nutrition 46 97–110CrossRefGoogle ScholarPubMed
Prosser, C. G., Fleet, I. R., Corps, A. N., Heap, R. B. & Froesch, E. R. 1988 Increased milk secretion and mammary blood flow during close-arterial infusion of insulin-like growth factor (IGF-1) into the mammary gland of the goat. Journal of Endocrinology 117 (suppl.) 248Google Scholar
Seldinger, S. L. 1953 A new technique: catheter replacement of the needle in percutaneous arteriography. Acta Radiologica 39 368–376CrossRefGoogle ScholarPubMed
Sherbon, J. W. 1978 Recent developments in determining protein content of dairy products by dye binding. Journal of Dairy Science 61 1274–1278CrossRefGoogle Scholar
Tindal, J. S., Knaggs, G. S., Hart, I. C. & Blake, L. A. 1978 Release of growth hormone in lactating and non-lactating goats in relation to behaviour, stages of sleep, electroencephalograms, environmental stimuli and levels of prolactin, insulin, glucose and free fatty acids in the circulation. Journal of Endocrinology 76 333–346CrossRefGoogle ScholarPubMed