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The induction by exogenous hormones of enzymes metabolising glucose 6-phosphate in the mammary gland of the pseudopregnant rabbit

Published online by Cambridge University Press:  01 June 2009

R. J. Heitzman
R. J. Heitzman
Affiliation:
Institute for Research on Animal Diseases, Compton, Newbury, Berkshire
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Summary

A study was made of the effects of the hormones, prolactin and cortisol acetate, on the activities in the mammary gland of the pseudopregnant rabbit of the enzymes concerned with lactose biosynthesis and glucose 6-phosphate metabolism, namely: UDP-glucose pyrophosphorylase, UDP-glucose-4'-epimerase, phosphofructokinase, phosphoglucomutase, glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Significant increases in enzyme activities were observed in rabbits examined 3 or 4 days after receiving a mammary intraductal injection of prolactin. The activities were not significantly increased at examination 2 days after injection of prolactin. Rabbits receiving cortisol acetate each day for 3 days also showed no significant increases in mammary enzyme activity. However, when prolactin and cortisol acetate were given simultaneously over a period of 3 days, increased enzyme activities were found suggesting synergistic action of the hormones.

Type
Original Articles
Information
Journal of Dairy Research , Volume 36 , Issue 1 , February 1969 , pp. 47 - 52
Copyright
Copyright © Proprietors of Journal of Dairy Research 1969

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References

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