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Genome-wide association study for buffalo mammary gland morphology

Published online by Cambridge University Press:  02 March 2020

Jun Li ,
Jiajia Liu ,
Shenhe Liu ,
Giuseppe Campanile ,
Angela Salzano ,
Bianca Gasparrini ,
Graham Plastow ,
Chunyan Zhang ,
Zhiquan Wang  and
Aixin Liang
...Show all authors
Jun Li
Affiliation:
Department of Immunology, Zunyi Medical University, Zunyi563000, People's Republic of China Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan430070, People's Republic of China
Jiajia Liu
Affiliation:
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan430070, People's Republic of China School of Biological Science and Technology, University of Jinan, Jinan, China
Shenhe Liu
Affiliation:
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan430070, People's Republic of China
Giuseppe Campanile
Affiliation:
Department of Veterinary Medicine and Animal Productions, University of Naples “Federico II”, Naples, Italy
Angela Salzano
Affiliation:
Department of Veterinary Medicine and Animal Productions, University of Naples “Federico II”, Naples, Italy
Bianca Gasparrini
Affiliation:
Department of Veterinary Medicine and Animal Productions, University of Naples “Federico II”, Naples, Italy
Graham Plastow
Affiliation:
Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
Chunyan Zhang
Affiliation:
Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
Zhiquan Wang
Affiliation:
Department of Agricultural, Food, and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
Aixin Liang
Affiliation:
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan430070, People's Republic of China
Liguo Yang*
Affiliation:
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan430070, People's Republic of China
*
Author for correspondence: Liguo Yang, Email: [email protected]
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Abstract

This research communication describes a genome-wide association study for Italian buffalo mammary gland morphology. Three single nucleotide polymorphisms (AX-85117983, AX-8509475 and AX-85117518) were identified to be significantly associated with buffalo anterior teat length, posterior teat length and distance between anterior and posterior teat, respectively. Two significant signals for buffalo mammary gland morphology were observed in two genomic regions on the chromosome 10, and chromosome 20. One of the regions located on the chromosome 10 has the most likely candidate genes ACTC1 and GJD2, both of which have putative roles in the regulation of mammary gland development. This study provides new insights into the genetic variants of buffalo mammary gland morphology and may be beneficial for understanding of the genetic regulation of mammary growth.

Keywords

ACTC1genetic variantsGJD2QTLteat
Type
Research Article
Information
Journal of Dairy Research , Volume 87 , Issue 1 , February 2020 , pp. 27 - 31
Copyright
Copyright © Hannah Dairy Research Foundation 2020

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