Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-18T12:22:18.507Z Has data issue: false hasContentIssue false
  • English
  • Français

Fermented camel milk prevents carbon tetrachloride induced acute injury in kidney of mice

Published online by Cambridge University Press:  22 May 2018

Houda Hamed ,
Manel Gargouri ,
Salha Boulila ,
Fatma Chaari ,
Ferdaws Ghrab ,
Rim Kallel ,
Zied Ghannoudi ,
Tahia Boudawara ,
Semia Chaabouni  and
Abdelfattah El Feki
...Show all authors
Houda Hamed*
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Manel Gargouri
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Salha Boulila
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Fatma Chaari
Affiliation:
Enzyme Bioconversion Unit (UR13ES74), National School of Engineering, P.O. Box 1173-3038, Sfax University, Tunisia
Ferdaws Ghrab
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Rim Kallel
Affiliation:
SMS diagnostic, P.O. Box 2034, Zahra, Tunisia
Zied Ghannoudi
Affiliation:
Anatomopathology Laboratory, CHU Habib Bourguiba, Sfax, Tunisia
Tahia Boudawara
Affiliation:
SMS diagnostic, P.O. Box 2034, Zahra, Tunisia
Semia Chaabouni
Affiliation:
Enzyme Bioconversion Unit (UR13ES74), National School of Engineering, P.O. Box 1173-3038, Sfax University, Tunisia
Abdelfattah El Feki
Affiliation:
Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Sfax, Tunisia
Ahmed Gargouri
Affiliation:
Research Unit of Toxicology, Environmental Microbiology and Health, Faculty of Science of Sfax, University of Sfax, Sfax 3064, Tunisia
*
*For correspondence; e-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Fermented milk is known to possess potent antioxidant activity. The present study was undertaken to assess the preventive effect of fermented camel milk (FCM) prepared using lactococcus lactis subsp. cremoris against CCl4 induced kidney damage in mice. Nephrotoxicity was induced in mice by a single dose of CCl4 (10 ml/kg 0·3% olive oil, ip). Female mice were pretreated daily with FCM for 15 d. Renal damage was associated with an increase in oxidative stress parameters (lipid peroxidation, protein carbonyl and changes in antioxidant enzyme activities and non-enzymatic antioxidant) and nephropathology markers.

The renal injury induced by CCl4 was confirmed by the histological study of the CCl4-intoxicated mice. Pretreatment with FCM significantly prevented renal dysfunction by reducing oxidative stress, while mice recovered normal kidney histology. Moreover, FCM prevented toxicity biomarker changes by reducing creatinine, urea, uric acid, lactate dehydrogenase (LDH) and electrolytes levels in plasma. These data indicate that FCM is efficient in inhibiting oxidative stress induced by CCl4, and suggests that the administration of this milk may be helpful in the prevention of kidney damage.

Keywords

Fermented camel milkCCl4oxidative stressmicekidney
Type
Research Article
Information
Journal of Dairy Research , Volume 85 , Issue 2 , May 2018 , pp. 251 - 256
Copyright
Copyright © Hannah Dairy Research Foundation 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

†

Houda Hamed and Manel Gargouri contributed equally to this work

References

Aebi, H 1984 Catalase in vitro. Methods in Enzymology 105 121–126Google Scholar
Bellassoued, K, Ben Hsouna, A, Athmouni, K, Pelt, JV, Makni Ayadi, F, Rebai, T & Elfeki, A 2018 Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats. Lipids in Health and Disease 17 9Google Scholar
Beyer, WF & Fridovich, I 1987 Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Analytical Biochemistry 161 559–66Google Scholar
Dashti-Khavidaki, S, Shahbazi, F, Khalili, H & Lessan-Pezeshki, M 2012 Potential renoprotective effects of silymarin againstnephrotoxic drugs: a review of literature. Journal of Pharmacy & Pharmaceutical Sciences 15 112–123Google ScholarPubMed
Desrouillères, K, Millette, M, DangVu, K, RTouja, R & Lacroix, M 2017 Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine. Journal of Functional Foods 17 816–827Google Scholar
El-kholy, TA, Hassanen, NHM & Abbas, HY 2013 Protection of the mushroom (shiitake “Lentinus-edodes) against carbon-tetrachloride-induced renal injury in rats. Life Sciences 10 1701–1708Google Scholar
Ellman, GL 1959 Tissue sulphydryl groups. Archives of Biochemistry and Biophysics 82 70–77CrossRefGoogle Scholar
Fardet, A & Rock, E 2017 In vitro and in vivo antioxidant potential of milks, yoghurts, fermented milks and cheeses: a narrative review of evidence. Nutrition Research Reviews 2 1–19Google Scholar
Fernández, M, Hudson, JA, Korpela, R & Reyes-Gavilán, CG 2015 Impact on human health of microorganisms present in fermented dairy products: An overview. BioMed Research International 13 1–13Google Scholar
Flohe, L & Gunzler, WA 1984 Assays of glutathione peroxydase. Methods in Enzymology 105 114–121Google Scholar
Gobbetti, M, Minervini, F & Rizzello, CG 2004 Angiotensin I converting-enzyme-inhibitory and antimicrobial bioactive peptides. International Journal of Dairy Technology 57 172–188Google Scholar
Güven, A, Güven, A & Gülmez, M 2003 The effect of kefir on the activities of GSH-Px, GST, CAT, and LPO levels in carbon tetrachloride-induced mice tissue. Journal of Veterinary Medicine 50 412–416CrossRefGoogle Scholar
Hamed, H, Chaari, F, Ghannoudi, Z, ElFeki, A, Chaabouni Ellouz, S & Gargouri, A 2017 Beneficial effects of fermented camel milk by lactococcus lactis subsp cremoris on cardiotoxicity induced by carbon tetrachloride in mice. Biomedicine & Pharmacotherapy 97 107–114CrossRefGoogle ScholarPubMed
Jacques-Silva, MC, Nogueira, CW, Broch, LC, Flores, EMM & Rocha, JBT 2001 Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmeutical Toxicoloy 88 119–125CrossRefGoogle ScholarPubMed
Jollow, DJ, Mitchell, JR, Zampaglione, N & Gillette, JR 1974 Bromobenzene-induced liver necrosis: protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11 151–169Google Scholar
Karakus, A, Değer, Y & Yıldırım, S 2016 Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats. Renal Failure 39 1–6Google Scholar
Khan, MR, Rizvi, W, Khan, GN, Khan, RA & Sheen, S 2009 Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata. Journal of Ethnopharmacology 122 91–99Google Scholar
Lowry, OH, Rosebrugh, NJ & Farr, AL 1951 Protein measurement with folin phenol reagent. Journal of Biological Chemistry 193 265–275Google Scholar
Ma, JQ, Luo, RZ, Jiang, HX & Liu, CM 2016 Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Functional Foods 7 549–556CrossRefGoogle ScholarPubMed
Mbarki, S, Alimi, H, Bouzenn, H, Elfeki, A & Hfaiedh, N 2017 Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat. Biomedicine & Pharmacotherapy 88 19–26Google Scholar
Moreno-Fernandez, J, Diaz-Castro, J, Alferez Maria, JM, Boesch, C, Nestares, T & Lopez-Aliag, I 2017 Fermented goat milk improves antioxidant status and protects from oxidative damage to bimolecular during anemia recovery. Journal of the Science of Food and Agriculture 97 1433–1442CrossRefGoogle Scholar
Moslehishad, M, Mirdamad, S, Ehsani, MR, Ezzatpanah, H & Moosavi-Movahed, AA 2013 The proteolytic activity of selected lactic acid bacteria in fermenting cow's and camel's milk and the resultant sensory characteristics of the products. International Journal of Dairy Technology 66 279–285Google Scholar
Ogeturk, M, Kus, I, Colakoglu, N, Zararsiz, I, Ilhan, NM & Sarsilmaz, M 2005 Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats. Journal of Ethnopharmacol 97 273–280CrossRefGoogle ScholarPubMed
Osman, MA, Abdel Rahman, IE & Dirar, AH 2010 Biochemical changes occurring during fermentation of camel by selected bacterial starter cultures. African Journal of Biotechnology 9 7331–7336Google Scholar
Reznick, AZ & Packer, L 1994 Oxidative damage to proteins: spectrophotometric method for carbonyl. Methods Enzymology 23 357–359CrossRefGoogle Scholar
Safhi, MM 2017 Nephroprotective effect of Zingerone against CCl4-induced renal toxicity in Swiss albino mice: molecular mechanism. Oxidative Medicine and Cellular Longevity 7 1–7Google Scholar
Sajid, M, Khan, MR, Shah, NA, Ullah, S, Younis, T, Majid, M, Ahmad, B & Nigussie, D 2016 Proficiencies of Artemisia scoparia against CCl4 induced DNA damages and renal toxicity in rat. BMC Complementary Alternative Medicine 16 149Google Scholar
Shiby, VK & Mishra, HN 2013 Fermented milks and milk products as functional foods—A review. Critical Reviews in Food Science and Nutrition 53 482–496Google Scholar
Stoyanovsky, D & Cederbaum, AI 1999 Metabolism of carbon tetrachloride to trichlo-romethylradical: an ESR and HPLC-EC study. Chemical Research in Toxicology 12 730–736Google Scholar
Yagi, K 1976 A simple fluorometric assay for lipoperoxide in blood plasma. Biochemistry Medicine 15 212–216Google Scholar
Supplementary material: PDF

Hamed et al. supplementary material

Figure S1

Download Hamed et al. supplementary material(PDF)
PDF 586.3 KB