Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-26T01:55:20.107Z Has data issue: false hasContentIssue false
  • English
  • Français

Additive and dominance effects of the αs1-casein locus on milk yield and composition traits in dairy goats

Published online by Cambridge University Press:  01 August 2012

Felicitas Vázquez-Flores ,
Hugo H Montaldo ,
José A Torres-Vázquez ,
Rogelio A Alonso-Morales ,
Amanda Gayosso-Vázquez ,
Mauricio Valencia-Posadas  and
Héctor Castillo-Juárez
Felicitas Vázquez-Flores
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Benemérita Universidad Autónoma de Puebla, 75482 Tecamachalco, Puebla, Mexico
Hugo H Montaldo*
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de México, 04510 Distrito Federal, Mexico
José A Torres-Vázquez
Affiliation:
Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, 76280 Querétaro, México
Rogelio A Alonso-Morales
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de México, 04510 Distrito Federal, Mexico
Amanda Gayosso-Vázquez
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de México, 04510 Distrito Federal, Mexico
Mauricio Valencia-Posadas
Affiliation:
División de Ciencias de la Vida, Campus Irapuato-Salamanca, Universidad de Guanajuato, 36500 Irapuato, Guanajuato, Mexico
Héctor Castillo-Juárez
Affiliation:
Departamento de Producción Agrícola y Animal, Universidad Autónoma Metropolitana-Xochimilco, 04960, Distrito Federal, Mexico
*
*For correspondence; e-mail: [email protected]; [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The objective of this study was to evaluate the effects of the CSN1S1 locus polymorphism on 305-d records of milk, fat, protein, lactose and total solids yields, fat, protein, lactose and total solids contents in Mexican dairy goats. A total of 514 lactation records belonging to Alpine (n=60), Saanen (n=105) and Toggenburg (n=74) goats, born from 2003 to 2006 in three herds were used. Discrimination between alleles E, F, N, A* (CSN1S1 A, G, H, I, O1 and O2) and B* (CSN1S1 B1, B2, B3, B4, C and L) were made by amplification of fragments of the gene CSN1S1 and digestion with the restriction endonuclease XmnI. In order to estimate additive and dominance effects, data sets including (1) all genotypes, and (2) only homozygote genotypes, were analysed using linear mixed models. The allele A*, had significant additive effects for protein content (0·21±0·07%; P=0·002) and total solids content (0·66±0·23%; P=0·005) when compared with allele F. An unfavourable additive effect of allele A* on milk yield was found in the Alpine breed (−81·4±40·2; P=0·046) when compared with allele F. Favourable dominance effects were found for some genotypes (P<0·05) for milk yield (A*N and B*N), fat yield (A*N and B*E), protein yield (A*N and B*E), lactose yield (A*N) and total solids yield (A*N). Also, unfavourable dominance effects were found (P<0·05) for protein content (A*B* and A*N) and total solids content (A*B*, A*N, and A*F). Allele A* was the only one with a positive effect for protein content. Significant allele-year interaction effects were also observed. The presence of significant dominance effects, estimated between specific pairs of alleles, challenged the purely additive nature of the genetic effect at the CSN1S1 locus. Implications from use of CSN1S1 effects in goat breeding programmes are presented.

Keywords

CSN1S1alpha-s1 caseinmilk traitdairy goatdominance effect
Type
Research Article
Information
Journal of Dairy Research , Volume 79 , Issue 3 , August 2012 , pp. 367 - 374
Copyright
Copyright © Proprietors of Journal of Dairy Research 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Analla, M, Angulo-Heras, C & Serradilla, JM 2000 Comparaison de l'effet des allèles de la caséine αs1 sur le taux protéique du lait entre deux races caprines et deux milieux. In: Joint ANPA-EAAP-CIHEAM-FAO International Symposium on Livestock Production and Climatic Uncertainty in the Mediterranean, Agadir, Morocco. pp. 247–250 Google Scholar
Barbieri, ME, Manfredi, E, Elsen, JM, Ricordeau, G, Bouillon, J, Grosclaude, F, Mahé, MF & Bibé, B 1995 Influence du locus de la caséine αs1 sur les performances laitières et les paramètres génétiques des chèvres de race Alpine. Genetics Selection Evolution 27 437–450 CrossRefGoogle Scholar
Chilliard, Y, Rouel, J & Leroux, C 2006 Goat's alpha-s1 casein genotype influences its milk fatty acid composition and delta-9 desaturation ratios. Animal Feed Science and Technology 131 474–487 CrossRefGoogle Scholar
Clark, S & Sherbon, JW 2000 Alphas1-casein, milk composition and coagulation properties of goat milk. Small Ruminant Research 38 123–134 CrossRefGoogle Scholar
CONAGUA, Comisión Nacional del Agua 2011 http://smn.cna.gob.mx/index.php?option=com_content&view=article&id=12:temperatura-y-precipitacion&catid=6:slider&Itemid=65 (accessed 12 November 2011)Google Scholar
Dagnachew, BS, Thaller, G, Lien, S & Åndøy, T 2011 Casein SNP in Norwegian goats: additive and dominance effects on milk composition and quality. Genetics Selection Evolution 43 1–31 CrossRefGoogle ScholarPubMed
Gama, LT & Bressan, MC 2011 Biotechnology applications for the sustainable management of goat genetic resources. Small Ruminant Research 98 133–146 CrossRefGoogle Scholar
Gómez-Ruiz, JA, Miralles, B, Agüera, P & Amigo, L 2004 Quantitative determination of as2- and as1-casein in goat's milk with different genotypes by capillary electrophoresis. Journal of Chromatography A 1054 279–284 CrossRefGoogle Scholar
Grosclaude, F, Mahé, MF, Brignon, G, Di Stasio, L & Jeunet, R 1987 A Mendelian polymorphism underlying quantitative variations of goat αs1-casein. Genetics, Selection, Evolution 19 399–412 CrossRefGoogle Scholar
Hayes, B, Hagesaether, N, Ådnoy, T, Pellerud, G, Berg, PR & Lien, S 2006 Effects on production traits of haplotypes among casein genes in Norwegian goats and evidence for a site of preferential recombination. Genetics 174 455–464 CrossRefGoogle ScholarPubMed
ICAR, International Committee for Animal Recording 2011. http://www.icar.org (accessed 23 November 2011)Google Scholar
Maga, EA, Daftari, P, Kültz, D & Penedo, MCT 2009 Prevalence of αs1-casein genotypes in American dairy goats. Journal of Animal Science 87 3464–3469 CrossRefGoogle ScholarPubMed
Mahé, MF, Manfredi, E, Ricordeau, G, Piacere, A & Grosclaude, F 1993 Effects of the alpha-s1-casein polymorphism on goat dairy performances: within-sire analysis of alpine bucks. Genetics Selection Evolution 26 151–157 CrossRefGoogle Scholar
Manfredi, E, Barbieri, ME, Bouillon, J, Piacère, A, Mahe, MF, Grosclaude, F & Ricordeau, G 1993 Effects of αS1 casein variants on dairy performance in goats. Lait 73 567–572 CrossRefGoogle Scholar
Martin, P & Leroux, C 2000 Le gène caprin spécifiant la caséine αs1: un suspect tout désigné aux effets aussi multiples qu'inattendus. INRA Production Animal Special issue, Molecular genetics: principles and applications in animal populations 125–132 http://granit.jouy.inra.fr/productions-animales/2000_hors-serie/Prod_Anim_2000_hs_hs_19.pdf (accessed 23 November 2011)CrossRefGoogle Scholar
Martin, P, Szymanowska, M, Zwierzchowski, L & Leroux, C 2002 The impact of genetic polymorphisms on the protein composition of ruminant milks. Reproduction Nutrition Development 42 433–459 CrossRefGoogle ScholarPubMed
Montaldo, HH & Manfredi, E 2002 Organization of selection programs for dairy goats. In: 7th World Congress on Genetics Applied to Livestock Production, Montpellier, France. pp. 191–196 Google Scholar
Montaldo, HH, Torres-Hernández, G & Valencia-Posadas, M 2010 Goat breeding research in Mexico. Small Ruminant Research 89 155–163 Google Scholar
Pagano, RI, Pennisi, P, Valenti, B, Lanza, M, Di Trana, A, Di Gregorio, P, De Angelis, A & Avondo, M 2010 Effect of CSN1S1 genotype and its interaction with diet energy level on milk production and quality in Girgentana goats fed ad libitum. Journal of Dairy Research 77 245–251 CrossRefGoogle ScholarPubMed
Pirisi, A, Colin, O, Laurent, F, Scher, J & Parmentier, M 1994 Comparison of milk composition, cheesemaking properties and textural characteristics of the cheese from two groups of goats with a high or low rate of αs1-casein synthesis. International Dairy Journal 4 329–345 CrossRefGoogle Scholar
Ramunno, L, Cosenza, G, Pappalardo, M, Pastore, N, Gallo, D, Di Gregorio, P & Masina, P 2000 Identification of the goat CSN1S1F allele by means of PCR-RFLP method. Animal Genetics 31 342 CrossRefGoogle ScholarPubMed
Ramunno, L, Cosenza, G, Rando, A, Pauciullo, A, Illario, R, Gallo, D, Di Berardino, D & Masina, P 2005 Comparative analysis of gene sequence of goat CSN1S1 F and N alleles and characterization of CSN1S1 transcript variants in mammary gland. Gene 345 289–299 CrossRefGoogle Scholar
Remeuf, F 1993 Influence du polymorphisme génétique de la caséine αs1 caprine sur les caractéristiques physico-chimiques et technologiques du lait. Lait 73 549–557 Google Scholar
Ricordeau, G, Manfredi, E & Amigues, Y 2000 Effets du locus de la caséine αs1 sur les performances laitières des chèvres Poitevines. In: 7th International Conference on Goats, Tours, France. pp. 249–251 Google Scholar
Roncada, P, Gaviraghi, A, Liberatori, S, Canas, B, Bini, L & Greppi, GF 2002 Identification of caseins in goat milk. Proteomics 2 723–726 Google Scholar
Sacchi, P, Chessa, S, Budelli, E, Bolla, P, Ceriotti, G, Soglia, D, Rasero, R, Cauvin, E & Caroli, A 2005 Casein haplotype structure in five Italian goat breeds. Journal of Dairy Science 88 1561–1568 CrossRefGoogle ScholarPubMed
Sánchez, A, Ilahi, H, Manfredi, E & Serradilla, JM 2005 Potential benefit from using the αs1-casein genotype information in a selection scheme for dairy goats. Journal of Animal Breeding and Genetics 122 21–29 CrossRefGoogle Scholar
Soares, MAM, Rodrigues, MT, Mognol, GP, Ribeiro, LFC, Silva, JLC & Brancalhão, RMC 2009 Polymorphism of alpha s1-casein gene in a dairy goat herd in the southeastern region of Brazil. Revista Brasileira de Zootecnia 38 1026–1032 Google Scholar
Sztankóová, Z, Mátlová, V & Malá, G 2007 Genetic polymorphism at the CSN1S1 gene in two Czech goat breeds. Czech Journal of Animal Science 52 199–202 CrossRefGoogle Scholar
Torres-Vázquez, JA, Valencia-Posadas, M, Castillo-Juárez, H & Montaldo, HH 2009 Genetic and phenotypic parameters of milk yield, milk composition and age at first kidding in Saanen goats from Mexico. Livestock Science 126 147–153 CrossRefGoogle Scholar
Torres-Vázquez, JA, Vázquez, F, Montaldo, HH, Ulloa-Arvizu, R, Valencia, M, Gayosso, A & Alonso, RA 2008 Genetic polymorphism of the αs1-casein locus in five populations of goats from Mexico. Electronic Journal of Biotechnology 11 1–11 http://www.ejbiotechnology.info/content/vol11/issue3/abstract/11/index.html (accessed 23 November 2011)CrossRefGoogle Scholar
Zeng, SS, Soryal, K, Fekadu, B, Bah, B & Popham, T 2007 Predictive formulae for goat cheese yield based on milk composition. Small Ruminant Research 69 180–186 CrossRefGoogle Scholar