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25-hydroxyvitamin D circulates in different fractions of calf plasma if the parent compound is vitamin D2 or vitamin D3, respectively

Published online by Cambridge University Press:  26 November 2015

Lone Hymøller  and
Søren K Jensen
Lone Hymøller*
Affiliation:
Department of Animal Science, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark
Søren K Jensen
Affiliation:
Department of Animal Science, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark
*
*For correspondence; e-mail: [email protected]
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Abstract

Vitamin D has become one of the most discussed nutrients in human nutrition, which has led to an increased interest in milk as a vitamin D source. Problems related to fortifying milk with synthetic vitamin D can be avoided by securing a high content of natural vitamin D in the milk by supplying dairy cows with sufficient vitamin D. However, choosing the most efficient route and form of supplementation requires insight into how different vitamin D metabolites are transported in the body of cattle. There are two forms of vitamin D: vitamin D2 (D2) and vitamin D3 (D3). Vitamin D2 originates from fungi on roughage. Vitamin D3 originates either from endogenous synthesis in the skin or from feed supplements. Vitamin D2 is chemically different from, and less physiologically active than, D3. Endogenous and dietary D3 is chemically similar but dietary D3 is toxic, whereas endogenous D3 appears well regulated in the body.

Keywords

Calfcattlecholecalciferolendogenousergocalciferollipoproteinsyntheticvitamin D2vitamin D3
Type
Research Article
Information
Journal of Dairy Research , Volume 83 , Issue 1 , February 2016 , pp. 67 - 71
Copyright
Copyright © Proprietors of Journal of Dairy Research 2015 

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References

Ametaj, BN, Nonnecke, BJ, Franklin, ST, Horst, RL, Bidlack, WR, Stuart, RL & Beitz, DC 2000 Dietary vitamin A modulates the concentrations of RRR-α-tocopherol in plasma lipoproteins from calves fed milk replacer. Journal of Nutrition 130 329–636CrossRefGoogle ScholarPubMed
Axis-Shield 2011 Fractionation of Mammalian and Non-Mammalian Plasma Lipoproteins. Application sheet M07. Fourth edition august 2011. http://www.axis-shield-density-gradient-media.com/M07.pdf (Accessed 4th February 2014)Google Scholar
Bauchart, D 1993 Lipid absorption and transport in ruminants. Journal of Dairy Science 76 3864–3881CrossRefGoogle ScholarPubMed
Diarrassouba, F, Garrait, G, Remondetto, G, Alvarez, P, Beyssac, E & Subirade, M 2015 Improved bioavailability of vitamin D3 using a β-lactoglobulin-based coagulum. Food Chemistry 172 361–367CrossRefGoogle ScholarPubMed
Dueland, S, Pedersen, JI, Helgerud, P & Drevon, CA 1983 Absorption, distribution, and transport of vitamin D3 and 25-hydroxyvitamin D3 in the rat. American Journal of Physiology 245 E463–E467Google ScholarPubMed
Gardner, RS, Ogden, NH, Cripps, PJ & Billington, D 2003 Separation of bovine plasma lipoproteins by a rapid ultra-centrifugation method. Journal of Comparative Pathology 128 15–23CrossRefGoogle Scholar
Haddad, JG, Matsuoka, LY, Hollis, BW, Hu, Y & Wortsman, J 1993 Human plasma transport of vitamin D after its endogenous synthesis. Journal of Clinical Investigation 91 2552–2555CrossRefGoogle ScholarPubMed
Herdt, TH & Smith, JC 1996 Blood-lipid and lactation-stage factors affecting serum vitamin E concentrations and vitamin E cholesterol ratios in dairy cattle. Journal of Veterinary Diagnostic Investigation 8 228–232CrossRefGoogle ScholarPubMed
Horst, RL, Reinhardt, TA, Russel, JR & Napoli, JL 1984 The isolation and identification of vitamin D2 and vitamin D3 from medicago sativa (alfalfa plant). Archives of Biochemistry and Biophysics 231 67–71CrossRefGoogle ScholarPubMed
Hymøller, L & Jensen, SK 2010a Stability in the rumen and effect on plasma status of single oral doses of vitamin D and vitamin E in high yielding dairy cows. Journal of Dairy Science 93 5748–5757CrossRefGoogle ScholarPubMed
Hymøller, L & Jensen, SK 2010b Vitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage. Journal of Dairy Science 93 2025–2029CrossRefGoogle ScholarPubMed
Hymøller, L & Jensen, SK 2011a Vitamin D2 impairs utilization of vitamin D3 in high-yielding dairy cows in a cross-over supplementation regimen. Journal of Dairy Science 94 3462–3466CrossRefGoogle Scholar
Hymøller, L & Jensen, SK 2011b Vitamin D analysis in plasma by high performance liquid chromatography (HPLC) with C30 reversed phase column and UV detection – easy and acetonitrile-free. Journal of Chromatography A 1218 1835–1841CrossRefGoogle ScholarPubMed
Jensen, SK, Jensen, C, Jakobsen, K, Engberg, RM, Andersen, JO, Lauridsen, C, Sørensen, P, Henckel, P, Skibsted, LH & Bertelsen, G 1998 Supplementation of broiler diets with retinol acetate, β-carotene or canthaxanthin: effect on vitamin and oxidative status of broilers in vivo and meat stability. Acta Agricultura Scandinavica, Animal Science 48 28–37Google Scholar
Kayden, HJ & Traber, MG 1993 Absorption, lipoprotein transport, and regulation of plasma concentration of vitamin E in humans. Journal of Lipid Research 34 343–358CrossRefGoogle ScholarPubMed
Kurmann, A & Indyk, H 1994 The endogenous vitamin D content of bovine milk: influence of season. Food Chemistry 50 75–81CrossRefGoogle Scholar
Leplaix-Charlat, L, Bauchart, D, Durand, D, Laplaud, PM & Chapman, MJ 1996 Plasma lipoproteins in pre-ruminant calves fed diets containing tallow or soybean oil wit and without cholesterol. Journal of Dairy Science 79 1267–1277CrossRefGoogle Scholar
Littell, RC, Milliken, GA, Stroup, WW, Wolfinger, RD & Schabenberger, O 2006 SAS® for MIXED Models, 2nd edition. Cary, NC: SAS Institute Inc., 813 ppGoogle Scholar
Maislos, M, Silver, J & Fainaru, M 1981 Intestinal absorption of vitamin D sterols: differential absorption into lymph and portal blood in the rat. Gastroenterology 80 1528–1534CrossRefGoogle ScholarPubMed
Nechama, H, Hoff, D, Harell, A & Edelstein, S 1977 The intestinal absorption of vitamin D and its metabolites. Journal of Molecular Medicine 2 413–422Google Scholar
Nigwekar, SU, Bhan, I & Thadhani, R 2012 Ergocalciferol and cholecalciferol in CKD. American Journal of Kidney Diseases 60 139–156CrossRefGoogle ScholarPubMed
Pysera, B & Opalka, A 2000 The effect of gestation and lactation of dairy cows on lipid and lipoprotein patterns and composition in serum during winter and summer feeding. Journal of Animal and Feed Sciences 9 411–424CrossRefGoogle Scholar
Richardson, MD & Logendra, S 1997 Ergosterol as an indicator of endophyte biomass in grass seeds. Journal of Agricultural and Food Chemistry 45 3903–3907CrossRefGoogle Scholar
Senaidy, AM 1996 Distribution of α- and γ-tocopherols within blood fractions of ruminants. Comparative Biochemistry and Physiology A 115 223–227CrossRefGoogle ScholarPubMed
Sneddon, JC, Walton, R & Bond, A 2004 A simplified technique for estimation of body surface area in horses and ponies. Equine and Comparative Exercise Physiology 1 51–60CrossRefGoogle Scholar
Thiel, RJ 2000 Natural vitamins may be superior to synthetic ones. Medical Hypotheses 55 461–469CrossRefGoogle ScholarPubMed