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3559 Mechanisms of sebaceous skin microbial community remodeling through microenvironment modulation.

Published online by Cambridge University Press:  26 March 2019

William Howard McCoy IV ,
Bruce Rosa ,
John Martin ,
Makedonka Mitreva  and
Jeffrey P. Henderson
William Howard McCoy IV
Affiliation:
Washington University in St. Louis
Bruce Rosa
Affiliation:
Washington University in St. Louis
John Martin
Affiliation:
Washington University in St. Louis
Makedonka Mitreva
Affiliation:
Washington University in St. Louis
Jeffrey P. Henderson
Affiliation:
Washington University in St. Louis
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Abstract

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OBJECTIVES/SPECIFIC AIMS: To understand the mechanisms of how a non-antimicrobial can reshape a commensal microbe community to cure a ubiquitous human disease. METHODS/STUDY POPULATION: Whole genome sequencing of bacterial isolates, metabolomic investigations of previously collected skin microbe isolates from patients, and structural investigations of a protein from these skin microbes. RESULTS/ANTICIPATED RESULTS: Metabolic pathways associated with adaptation to a changing skin microenvironment, novel antimicrobial characterization, and a structural understanding of a novel nutrient acquisition protein. DISCUSSION/SIGNIFICANCE OF IMPACT: Multiple angles of this investigation are poised to improve current non-antimicrobial dermatologic treatments and they have the potential to impact microbe-related diseases in other human microenvironments.

Type
Mechanistic Basic to Clinical
Information
Journal of Clinical and Translational Science , Volume 3 , Issue s1 , March 2019 , pp. 109
Creative Commons
Creative Common License - CCCreative Common License - BYCreative Common License - NCCreative Common License - ND
This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-ncnd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
Copyright
© The Association for Clinical and Translational Science 2019