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2003 Mixed meal effects of neprilysin inhibition

Published online by Cambridge University Press:  21 November 2018

Jessica R. Wilson ,
Daniel Rader ,
Raymond Townsend  and
Michael Rickels
Jessica R. Wilson
Affiliation:
University of Pennsylvania School of Medicine
Daniel Rader
Affiliation:
Department of Medicine, Division of Nephrology and Hypertension, University of Pennsylvania
Raymond Townsend
Affiliation:
Department of Medicine, Division of Endocrinology, University of Pennsylvania
Michael Rickels
Affiliation:
Department of Medicine, Division of Nephrology and Hypertension, University of Pennsylvania
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Abstract

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OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1.

Type
Basic/Translational Science/Team Science
Information
Journal of Clinical and Translational Science , Volume 2 , Supplement S1 , June 2018 , pp. 44
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Association for Clinical and Translational Science 2018