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Spontaneous Abortion and Birth Order

Published online by Cambridge University Press:  31 July 2008

William H. James
William H. James
Affiliation:
The Galton Laboratory, University College London
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Summary

It is well established that, in general, pregnancies at advanced maternal ages or of advanced birth order are at greater risk of aborting spontaneously. It does not follow that each individual woman, as she proceeds through her reproductive life, becomes steadily more prone to abort. The present paper attempts to analyse evidence on how individual women's abortion probabilities vary during their reproductive lives. Statistical examination of the data suggests that:

1. A spontaneous abortion in a given birth rank is more likely than a live birth in the same rank to be followed by a further pregnancy. Abortion-prone women have more pregnancies than other women.

2. There is no significant overall tendency for spontaneous abortions to appear early or late in sibships even when account is taken of the reproductive compensation reported above.

3. Pathological examination of spontaneously aborted fetuses suggests that more (perhaps many more) than 10% of spontaneous abortions (e.g. those associated with trisomy and maternal isoimmunization) are causally associated with advanced maternal age or birth order.

4. The mean maternal age of spontaneously aborted fetuses which fail to grow in culture is higher than that of fetuses which are successfully cultured.

One would infer:

A. (from suggestions 1 and 2 above) that reproductive compensation (rather than a real birth order effect) is a major reason why abortion rates are higher at higher maternal ages and higher birth ranks;

B. (from suggestions 2 and 3 above) that there must be another group of abortions, roughly equal in number, which are causally associated with low maternal age or early birth order.

Little is known about this second group of reproductive casualties (those associated with low birth order or maternal age), but it is suggested that some have CNS malformations. I have made similar suggestions in regard to stillbirth and neonatal death.

Type
Research Article
Information
Journal of Biosocial Science , Volume 6 , Issue 1 , January 1974 , pp. 23 - 41
Copyright
Copyright © Cambridge University Press 1974

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References

Boué, J.G., Boué, A. & Lazar, P. (1969) Correlation entre les différentes anomalies chromosomiques observées dans les avortements spontanés et les âges maternels. C. r. Acad. Sci. Paris, 269, 680.Google Scholar
Carr, D.H. (1965) Chromosome studies in spontaneous abortion. Obstet. Gynec., N. Y. 26, 308.Google Scholar
Carr, D.H., Bateman, A.J. & Murray, A.B. (1966) Analysis of data from abortuses which failed to grow in culture. Obstet. Gynec., N.Y. 28, 611.Google ScholarPubMed
Coombs, L., Freedman, R. & Namboothiri, D.N. (1969) Inferences about abortion from foetal mortality data. Popul. Stud. 23, 247.CrossRefGoogle ScholarPubMed
Diddle, A.W. (1955) In: Discussion, Schoeneck, F.J. Conception effort time in relation to fetal wastage. Am. J. Obstet. Gynec. 69, 657.Google Scholar
Erhardt, C.L. & Jacobziner, H. (1956) Ectopic pregnancies and spontaneous abortions in New York City—incidence and characteristics. Am. J. publ. Hlth, 46, 828.Google Scholar
Freedman, R., Coombs, L.C. & Friedman, J. (1966) Social correlates of fetal mortality. Milbank meml Fund q. Bull. 44, 327.Google Scholar
Freire-Maia, N. (1964) Pregnancy order and risk of abortion. Lancet, i, 564.Google Scholar
French, F.E. & Bierman, J.M. (1962) Probabilities of fetal mortality. Publ. Hlth Rep. 77, 835.Google Scholar
Gebhard, P.H., Pomeroy, W.B., Martin, C.E. & Christenson, C.V. (1958) Pregnancy, Birth and Abortion. Harper, New York.Google Scholar
German, J. (1968) Mongolism, delayed fertilization and sexual behaviour. Nature, Lond. 217, 516.Google Scholar
Goldzieher, J.W. & Benigno, B. (1958) The treatment of threatened and recurrent abortion: a critical review. Am. J. Obstet. Gynec. 75, 1202.Google Scholar
Haldane, J.B.S. & Smith, C.A.B. (1947) A simple exact test for birth order effect. Ann. Eugen. 14, 117.Google Scholar
Hammond, J. (1955) The effects of nutrition on fertility. In: The Numbers of Man and Animals. Edited by Cragg, J.B. & Pirie, N.W.. Oliver & Boyd, London.Google Scholar
Henry, L. (1958) Intervals between confinements in the absence of birth control. Eugen. Q. 5, 200.CrossRefGoogle Scholar
Illsley, R. (1967) The sociological study of reproduction and its outcome. In: Childbearing, its Social and Psychological Aspects. Edited by Richardson, S.A. & Guttmacher, A.F.. Williams & Wilkins, Baltimore.Google Scholar
Jain, A.K. (1969) Fetal wastage in a sample of Taiwanese women. Milbank meml Fund q. Bull. 47, 297.Google Scholar
James, W.H. (1963) Notes towards an epidemiology of spontaneous abortion. Am. J. hum. Genet. 15, 223.Google ScholarPubMed
James, W.H. (1967) Psychological and other Factors in the Aetiology of Human Foetal Wastage. Ph.D. thesis, University of London.Google Scholar
James, W.H. (1968a) Stillbirth and birth order. Ann. hum. Genet. 32, 151.CrossRefGoogle ScholarPubMed
James, W.H. (1968b) Stillbirth, neonatal death and birth interval. Ann. hum. Genet. 32, 163.CrossRefGoogle ScholarPubMed
James, W.H. (1968c) Mongolism, delayed fertilization and sexual behaviour. Nature, Lond. 219, 279.Google Scholar
James, W.H. (1969a) Central nervous system malformation stillbirths, maternal age and birth order. Ann. hum. Genet. 32, 223.CrossRefGoogle ScholarPubMed
James, W.H. (1969b) Testing for birth order effects in the presence of birth limitation or reproductive compensation. J. R. statist. Soc. Series C (Applied Statistics), 18, 276.Google Scholar
James, W.H. (1970) Neonatal death and birth order. Ann. hum. Genet. 33, 385.Google Scholar
Javert, C.T. (1957) Spontaneous and Habitual Abortion. McGraw-Hill, New York.Google Scholar
Kinsey, A.C., Pomeroy, W.B. & Martin, C.E. (1948) Sexual Behavior in the Human Male. Saunders, Philadelphia.Google Scholar
Kinsey, A.C., Pomeroy, W.B., Martin, C.E. & Gebhard, P.H. (1953) Sexual Behavior in the Human Female. Saunders, Philadelphia.Google Scholar
Macleod, J. & Gold, R.Z. (1957) The male factor in fertility and infertility. Fert. Steril. 8, 36.Google Scholar
MacMahon, B., Hertig, A.T. & Ingalls, T. (1954) Association between maternal age and pathological diagnosis in abortion. Obstet. Gynec., N. Y. 4, 477.Google ScholarPubMed
Malpas, P. (1942) The categories of abortions and abortion-stillbirth sequences. J. Obstet. Gynaec. Br. Emp. 49, 65.CrossRefGoogle Scholar
Morris, J.N. & Heady, J.A. (1955) Social and biological factors in infant mortality. Lancet, i, 343.Google Scholar
Newcombe, H.B. & Rhynas, P.O.W. (1962) Child spacing following stillbirth and infant death. Eugen. Q. 9, 25.CrossRefGoogle ScholarPubMed
Parsons, P.A. (1964) Parental age and the offspring. Q. Rev. Biol. 39, 258.Google Scholar
Potter, R.G., Wyon, J.B., New, M. & Gordon, J.E. (1965) Fetal wastage in 11 Punjab villages. Hum. Biol. 37, 262.Google Scholar
Reed, T.E. & Kelly, E.L. (1958) The completed reproductive performances of 161 couples selected before marriage and classified by ABO blood groups. Ann. hum. Genet. 22, 165.Google Scholar
Registrar General For Scotland (1964) Annual Report for 1963. HM Stationery Office, Edinburgh.Google Scholar
Rucker, M.P. (1952) Spontaneous abortions—too many or too few? J. int. Coll. Surg. 17, 328.Google ScholarPubMed
Schoeneck, F.J. (1953) Pregnancy patterns and fetal salvage. Obstet. Gynec., N. Y. 1, 610.Google ScholarPubMed
Shapiro, S., Jones, E.W. & Densen, P.M. (1962) A life table of pregnancy terminations and correlates of fetal loss. Milbank meml Fund q. Bull. 40, 7.Google Scholar
Sheps, M.C. (1965) An analysis of reproductive patterns in an American isolate. Popul. Stud. 19, 65.Google Scholar
Slater, E.T.O. (1962) Birth order and maternal age of homosexuals. Lancet, i, 69.CrossRefGoogle Scholar
Speert, H. (1954) Pregnancy prognosis following repeated abortion. Am. J. Obstet. Gynec. 68, 665.Google Scholar
Spicer, C.C. & Lipworth, L. (1966) Regional and Social Factors in Infant Mortality. General Register Office Studies on Medical and Population Subjects, No. 19. HM Stationery Office, London.Google Scholar
Stevenson, A.C., Dudgeon, M.Y. & McClure, H.I. (1959) Observations on the results of pregnancies in women resident in Belfast. Ann. hum. Genet. 23, 395.CrossRefGoogle ScholarPubMed
Tietze, C., Guttmacher, A.F. & Rubin, S. (1950) Unintentional abortion in 1479 planned pregnancies. J. Am. med. Ass. 142, 1348.CrossRefGoogle Scholar
Warburton, D. & Fraser, F.C. (1964) Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit. Am. J. hum. Genet. 16, 1.Google Scholar
Westoff, C.F., Potter, R.G., Sagi, P.C. & Mischler, E.G. (1961) Family Growth in Metropolitan America. University Press, Princeton.Google Scholar
Yerushalmy, J., Bierman, J.M., Kemp, D.H., Connor, A. & French, F.E. (1956) Longitudinal studies of pregnancy on the island of Kauai, Territory of Hawaii. Am. J. Obstet. Gynec. 71, 80.Google Scholar