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POSITIVE AND NEGATIVE LIFE CHANGES AND LDL CHOLESTEROL

Published online by Cambridge University Press:  01 April 1999

ANNELI HELMINEN ,
TUOMO RANKINEN ,
PIRJO HALONEN ,
SARI VÄISÄNEN  and
RAINER RAURAMAA
ANNELI HELMINEN
Affiliation:
Kuopio Research Institute of Exercise Medicine and Department of Physiology
TUOMO RANKINEN
Affiliation:
Kuopio Research Institute of Exercise Medicine and Department of Physiology
PIRJO HALONEN
Affiliation:
Computing Centre, University of Kuopio, Finland
SARI VÄISÄNEN
Affiliation:
Kuopio Research Institute of Exercise Medicine and Department of Physiology
RAINER RAURAMAA
Affiliation:
Kuopio Research Institute of Exercise Medicine and Department of Physiology
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Abstract

Epidemiological studies have revealed that stressful changes in social environment increase the risk of cardiovascular mortality. In this study, the influence of major negative and positive life changes on serum cholesterol was examined in middle-aged men to determine a possible biochemical link between life changes and cardiovascular mortality. The results showed no influence of negative life changes on serum cholesterols. However, positive life changes significantly predicted a reduction in total and LDL (low-density lipoprotein) cholesterol levels after adjustment for the baseline cardiovascular health status, baseline cholesterol level, diet, body mass index, waist-to-hip ratio and cardiorespiratory fitness. The odds ratio for lowering LDL cholesterol was 5·2 in the men reporting positive events compared with those reporting none. The findings suggest a predictive value of positive life changes for atherogenic lipid profile in middle-aged men.

Type
Research Article
Information
Journal of Biosocial Science , Volume 31 , Issue 2 , April 1999 , pp. 269 - 277
Copyright
© 1999 Cambridge University Press

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