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Family study in sickle Cell disease in Nigeria

Published online by Cambridge University Press:  31 July 2008

F. E. A. Lesi  and
Ekpo E. E. Bassey
F. E. A. Lesi
Affiliation:
Lagos University Teaching Hospital, P. M. B. 12003, Lagos, Nigeria
Ekpo E. E. Bassey
Affiliation:
Lagos University Teaching Hospital, P. M. B. 12003, Lagos, Nigeria
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Extract

A pilot survey has been made of Nigerian families at risk of producing SS haemoglobin homozygotes. Genotypes of parents and off-spring were investigated in twenty-five families. There is a suggestion that more SS children are produced where the first born suffers from haemoglobin SS disease. Mortality among offspring was higher in the study population than in the general population.

Type
Research Article
Information
Journal of Biosocial Science , Volume 4 , Issue 3 , July 1972 , pp. 307 - 313
Copyright
Copyright © Cambridge University Press 1972

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References

Konotey-Ahulu, F.D.I. (1970) Maintenance of high sickling rate in Africa—role of polygamy. J. trop. Med. Hyg. 73, 19.Google ScholarPubMed
Lehman, H. (1968) Haemoglobinopathies. In: Health Problems in Developing States. Proc. 4th Rehovoth Conference Israel, 1967. Edited by Moshe, Prywes & Michael, Davies. Grune & Stratton, New York.Google Scholar
Roberts, D. F. & Boyo, A. E. (1960) On the stability of haemoglobin gene frequencies in West Africa. Ann. hum. Genet. 24, 375.CrossRefGoogle ScholarPubMed