Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-28T04:08:04.150Z Has data issue: false hasContentIssue false

An asymptotic formula for the transition density of random genetic drift

Published online by Cambridge University Press:  14 July 2016

Peter L. Antonelli*
Affiliation:
University of Alberta

Abstract

Stochastic models in population genetics which lead to diffusion equations are considered. A geometric formula for the asymptotic expansions of the fundamental solutions of these equations is presented. Specifically, the random genetic drift process of one-locus theory and the Ohta–Kimura model of two-locus di-allelic systems with linkage are studied. Agreement with the work of Keller and Voronka for the two-allele one-locus case is obtained. For the general n-allele problem, the formulas obtained here are apparently new.

Type
Short Communications
Copyright
Copyright © Applied Probability Trust 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Antonelli, P. L. and Strobeck, C. (1977) The geometry of random drift, I. Stochastic distance and diffusion. Adv. Appl. Prob. 9, 238249.CrossRefGoogle Scholar
[2] Antonelli, P. L., Morgan, K. and Lathrop, G. M. (1977) The geometry of random drift, III. Recombination and diffusion. Adv. Appl. Prob. 9, 260267.Google Scholar
[3] Friedman, A. (1975) Stochastic Differential Equations and Applications, Vol. I. Academic Press, New York.Google Scholar
[4] Helgason, S. (1961) Differential Geometry and Symmetric Spaces. Academic Press, New York.Google Scholar
[5] Keller, J. B. and Voronka, R. (1975) Asymptotic analysis of stochastic models in population genetics. Math. Biosci. 25, 331362.Google Scholar
[6] Molchanov, S. A. (1975) Diffusion processes and Riemannian geometry. Russian Math. Survey 30, 175.CrossRefGoogle Scholar