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Of mice and men: solving the molecular mysteries of Huntington's disease

Published online by Cambridge University Press:  01 May 2000

P. F. SHELBOURNE
P. F. SHELBOURNE
Affiliation:
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
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Abstract

Recent advances in the manipulation of mouse embryos provide opportunities for the disciplines of neuroscience and molecular genetics to join forces and tackle some previously intractable questions in this area of research. Even Huntington's disease has started to yield clues to its complex pathophysiology as a result of the recent application of transgenic technologies. This short review, while necessarily providing some background clinical information on Huntington's disease, will focus on how modifications of the mouse genome have contributed, and are continuing to contribute, to our understanding of the complex disease process. Such new insights may well turn the hope of developing the first effective treatment for this devastating disease into reality.

Keywords

Trinucleotide repeat disorderstransgenic miceneurodegeneration
Type
Review
Information
The Journal of Anatomy , Volume 196 , Issue 4 , May 2000 , pp. 617 - 628
Copyright
© Anatomical Society of Great Britain and Ireland 2000

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