Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-12T21:36:14.609Z Has data issue: false hasContentIssue false

NMDA receptors in the basal ganglia

Published online by Cambridge University Press:  01 May 2000

PAULA RAVENSCROFT
Affiliation:
Manchester Movement Disorders Laboratory, University of Manchester, UK
JONATHAN BROTCHIE
Affiliation:
Manchester Movement Disorders Laboratory, University of Manchester, UK
Get access

Abstract

The basal ganglia consist of several interconnected nuclei located in the telecephalon, diencephalon and mesencephalon that are involved in a variety of motor and non-motor behavioural functions. Glutamate receptors play a major role in neurotransmission within the basal ganglia and are present in all nuclei of the basal ganglia. This review focuses on the contribution of the NMDA class of glutamatergic receptors to various movement disorders whose primary pathology lies within the basal ganglia and discusses how pharmacological manipulation of such receptors may be therapeutically useful.

Type
Research Article
Copyright
© Anatomical Society of Great Britain and Ireland 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)