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Morphogenesis of Doublefoot (Dbf), a mouse mutant with polydactyly and craniofacial defects

Published online by Cambridge University Press:  01 July 1998

CHRISTOPHER HAYES ,
MARY F. LYON  and
GILLIAN M. MORRISS-KAY
CHRISTOPHER HAYES
Affiliation:
Department of Human Anatomy, University of Oxford, UK
MARY F. LYON
Affiliation:
MRC Mammalian Genetics Unit, Harwell, UK
GILLIAN M. MORRISS-KAY
Affiliation:
Department of Human Anatomy, University of Oxford, UK
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Abstract

We report the morphogenesis of a new mouse mutant, Doublefoot (Dbf). The major phenotypic features involve the limb and craniofacial regions. There is polydactyly of all 4 limbs, with typically 6–8 digits per limb. All of the digits are triphalangeal; some show bifurcations and some are not attached to the carpus/tarsus. The carpus and tarsus are broader than normal, and their elements are partially fused. There are also tibial defects. Mutant embryos show a diencephalic bulge on d 10.0, with older animals exhibiting broadened and bulbous skulls sometimes with an additional midline skeletal element, shortened snouts and bulging eyes. Homozygotes, which do not survive beyond d 15, show midline facial clefting. In this study of the embryonic and fetal development of Dbf animals, we focus on the morphogenesis of the limbs and head, and discuss the possible molecular developmental mechanisms.

Keywords

Limb developmentSonic hedgehog
Type
Research Article
Information
The Journal of Anatomy , Volume 193 , Issue 1 , July 1998 , pp. 81 - 91
Copyright
© Anatomical Society of Great Britain and Ireland 1998

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