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Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation

Published online by Cambridge University Press:  20 March 2001

KAREN L. HOSKIN ,
DAVID C. E. BULMER ,
MICHELE LASALANDRA ,
ANJA JONKMAN  and
PETER J. GOADSBY
KAREN L. HOSKIN
Affiliation:
Department of Clinical Neurology, Institute of Neurology, London
DAVID C. E. BULMER
Affiliation:
Department of Clinical Neurology, Institute of Neurology, London
MICHELE LASALANDRA
Affiliation:
Department of Clinical Neurology, Institute of Neurology, London
ANJA JONKMAN
Affiliation:
Faculty of Medical Sciences, University Hospital, Groningen, The Netherlands
PETER J. GOADSBY
Affiliation:
Department of Clinical Neurology, Institute of Neurology, London
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Abstract

There is an accumulating body of evidence suggesting that the periaqueductal grey (PAG) is involved in the pathophysiology of migraine. Positron emission tomography (PET) studies in humans have shown that the caudal ventrolateral midbrain, encompassing the ventrolateral PAG, has activations during migraine attacks. The PAG may well be involved not only through the descending modulation of nociceptive afferent information, but also by its ascending projections to the pain processing centres of the thalamus. In this study the intranuclear oncogene protein Fos was used to mark cell activation in the PAG following stimulation of the trigeminally-innervated superior sagittal sinus (SSS) in both cats and in nonhuman primates (Macaca nemestrina). Fos expression in the PAG increased following stimulation to a median of 242 cells (interquartile range 236–272) in the cat and 155 cells (range 104–203) in the monkey, compared with control levels of 35 cells (21–50) and 26 cells (18–33), respectively. Activation was predominantly in the ventrolateral area of the caudal PAG suggesting that the PAG is involved following trigeminally-evoked craniovascular pain.

Keywords

Sagittal sinuscraniofacial painmigraine
Type
Research Article
Information
The Journal of Anatomy , Volume 198 , Issue 1 , January 2001 , pp. 29 - 35
Copyright
© Anatomical Society of Great Britain and Ireland 2001

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