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Aspects of PET imaging relevant to the assessment of striatal transplantation in Huntington's disease

Published online by Cambridge University Press:  01 May 2000

LAURENT BESRET ,
A. LISA KENDALL  and
STEPHEN B. DUNNETT
LAURENT BESRET
Affiliation:
Centre for Brain Repair, University of Cambridge, UK
A. LISA KENDALL
Affiliation:
Centre for Brain Repair, University of Cambridge, UK
STEPHEN B. DUNNETT
Affiliation:
Centre for Brain Repair, University of Cambridge, UK
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Abstract

Proper assessment of outcome in clinical trials of neural transplantation requires both biochemical and imaging indices of graft survival, and behavioural and physiological indices of graft function. For transplantation in Huntington's disease, a variety of ligands that are selective for striatal degeneration and graft-derived replacement are available, notably ligands of dopaminergic receptors on striatal neurons. However, the validity of such ligands is potentially compromised by adjunctive drug therapies (e.g. neuroleptics) given to patients in the course of normal clinical care. We review the present state of experimental and clinical understanding of the selectivity of available ligands for striatal imaging, their interaction with other drug treatments, and strategies for refining valid assessment protocols in patients.

Keywords

Huntington's diseasestriatal transplantationPET imaging
Type
Review
Information
The Journal of Anatomy , Volume 196 , Issue 4 , May 2000 , pp. 597 - 607
Copyright
© Anatomical Society of Great Britain and Ireland 2000

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