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Proliferative activity of preovulatory follicles and newly formed corpora lutea in cycling rats from late prooestrus to early oestrus

Published online by Cambridge University Press:  01 October 1997

FRANCISCO GAYTÁN ,
CARMEN BELLIDO ,
CONCEPCIÓN MORALES ,
ENRIQUE AGUILAR  and
JOSÉ EUGENIO SÁNCHEZ-CRIADO
FRANCISCO GAYTÁN
Affiliation:
Department of Cell Biology, Faculty of Medicine, University of Cordoba, Spain
CARMEN BELLIDO
Affiliation:
Department of Physiology, Faculty of Medicine, University of Cordoba, Spain
CONCEPCIÓN MORALES
Affiliation:
Department of Pathology, Faculty of Medicine, University of Cordoba, Spain
ENRIQUE AGUILAR
Affiliation:
Department of Physiology, Faculty of Medicine, University of Cordoba, Spain
JOSÉ EUGENIO SÁNCHEZ-CRIADO
Affiliation:
Department of Physiology, Faculty of Medicine, University of Cordoba, Spain
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Abstract

Ovaries from adult cycling rats were studied from 1600 h on the day of prooestrus to 0700 h on the day of oestrus in order to relate the cyclic hormonal changes to the proliferative activity of preovulatory and postovulatory (i.e. newly-formed corpora lutea) follicles. Proliferative activity was studied by the immunohistochemical demonstration of DNA-incorporated 5-bromodeoxyuridine (BrdU). The proliferative activity of granulosa cells (GC) in large preovulatory follicles showed a centripetal pattern and decreased during prooestrus, reaching a minimum at 2100 h. However, a proliferative wave was found in the GC of preovulatory follicles at 0200 h on the day of oestrus and in those of newly-formed corpora lutea at 0700 h on the day of oestrus. These results suggest that the granulosa cells of preovulatory follicles show maturational changes that followed a different pattern, depending on their location within the follicle, and that the proliferative wave found from 0200 to 0700 h on oestrus is important for the establishment of the number of steroidogenic cells in the cyclic corpus luteum.

Keywords

Ovarycorpus luteum
Type
Research Article
Information
The Journal of Anatomy , Volume 191 , Issue 3 , October 1997 , pp. 425 - 430
Copyright
© Anatomical Society of Great Britain and Ireland 1997

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