Published online by Cambridge University Press: 27 March 2009
Two fundamental explanations have been advanced to account for the unequal distribution of electrolytes on either side of a cell membrane: the one bases the unequal distribution on the existence of a cell membrane of so-called selective permeability, by which the membrane is endowed with the property of presenting varying resistance to the passage of different ions; the other regards the unequal distribution as being due to the selective action of the cell constituents themselves. This latter theory regards the cell primarily as a system in which the distribution of electrolytes is governed by the equilibrium existing on either side of a membrane permeable to electrolytes but impermeable to other ionised constituents of the cell.