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The long-term accumulation and depletion of copper in the liver of different breeds of sheep fed diets of differing copper content

Published online by Cambridge University Press:  27 March 2009

J. A. Woolliams ,
N. F. Suttle ,
G. Wiener ,
A. C. Field  and
C. Woolliams
J. A. Woolliams
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh, EH9 3JQ
N. F. Suttle
Affiliation:
Moredun Research Institute, 408 Oilmerton Road, Edinburgh, EH17 7JH
G. Wiener
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh, EH9 3JQ
A. C. Field
Affiliation:
Moredun Research Institute, 408 Oilmerton Road, Edinburgh, EH17 7JH
C. Woolliams
Affiliation:
ARC Animal Breeding Research Organisation, West Mains Road, Edinburgh, EH9 3JQ
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Summary

Changes in Cu concentration in the livers of adult Scottish Blackface (B), Welsh Mountain (W) and B × W ewes fed diets containing 4, 9, 17 and 29 mg Cu/kg D.M. were measured over a 28-week period. Measurement continued during two further periods of 18 weeks when first all sheep were fed the diet containing 4 mg Cu/kg D.M. and finally, when 4 mg Mo/kg D.M. was added to this diet.

During the first period the increase on all diets was least in B ewes and, apart from the 4 mg Cu/kg D.M. diet, greatest in W ewes; this difference increased as the Cu in the diet increased. The rate of increase for all ewes diminished towards the end of the period. All breed types retained proportionately less Cu in their livers as the Cu in the diet increased; at one extreme B ewes fed 17 or 29 mg Cu/kg D.M. retained equal amounts.

When during the second period all sheep were fed the 4 mg Cu/kg D.M. diet the Cu concentration in their livers decreased, the rate of decrease being greatest for ewes whose mean concentration in the liver was highest, but at similar concentrations the decrease was greater in B than W ewes. During the final period the decrease was faster and was again associated with the mean Cu concentration, but the decrease was not significantly affected by breed.

Throughout the trial, W ewes had the highest concentration of Cu in their plasma, whilst B ewes and ewes fed the 4 mg Cu/kg D.M. diet throughout had the lowest concentrations both in plasma and in their kidneys at slaughter.

The results show that breeds differ in their ability to retain Cu from the diet in their livers. The magnitude of these differences depends on the intake of Cu and Mo from the diet and is affected by the concentration of Cu in the liver. Breed differences in the absorption and endogenous loss of Cu are suggested.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 100 , Issue 2 , April 1983 , pp. 441 - 449
Copyright
Copyright © Cambridge University Press 1983

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