Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-12-03T20:31:45.161Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of triamcinolone on glucose metabolism in ketotic sheep

Published online by Cambridge University Press:  27 March 2009

E. J. H. Ford  and
Joan Evans
E. J. H. Ford
Affiliation:
University of Liverpool Veterinary Field Station, Leahurst, Neston, South Wirral
Joan Evans
Affiliation:
University of Liverpool Veterinary Field Station, Leahurst, Neston, South Wirral
Get access Rights & Permissions [Opens in a new window]

Summary

The withdrawal of food from Clun Forest ewes pregnant with twins produced signs of pregnancy toxaemia accompanied by a significant decrease in the concentration of glucose, a significant increase in the concentration of ketones, non-esterified fatty acids (NEFA) and 3-hydroxybutyrate in plasma and a significant decrease in total entry rate and irreversible loss of glucose. A single intramuscular injection of 0·05 or 0·2 mg/kg of triamcinolone acetonide had no significant effect on the concentration of glucose, ketones or 3-hydroxybutyrate in plasma or on the total entry, irreversible loss or recycling of glucose in ketotic or in normal pregnant sheep. The low dose had a significant effect on the concentration of NEFA in plasma. Recovery from the clinical signs was slow after either dose of steroid but appeared to be hastened by the onset of parturition which was more rapid after the higher dose.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 106 , Issue 2 , April 1986 , pp. 337 - 340
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bakker, N. & White, R. R. (1957). A simplified micro method for the determination of total acetone bodies in blood. New Zealand Journal of Science and Technology 38B, 1001–1008.Google Scholar
Bergmeyer, H. U. (1974). Methods of Enzymatic Analysis, 2nd edn. Verlag Chemie Weinheim IV, 1836. London and New York: Academic Press.Google Scholar
Drury, D. R. & Wick, A. N. (1952). The effect of β-hydroxybutyric acid on glucose oxidation in insulinized animals. Journal of Biological Chemistry 196, 129.CrossRefGoogle ScholarPubMed
Fischer, W. (1971). Behandlungsversuche bei de Azetonamie des Rindes mit Triamcinolon-Acetonid. Deutsche Tierärztliche Wochenschrift 78, 402–405.Google Scholar
Flint, A. P. F., Anderson, A. B. M., Steele, P. A. & Turnbull, A. C. (1975). The mechanism by which foetal cortisol controls the onset of parturition in the sheep. Biochemical Society Transactions 3, 1189.CrossRefGoogle Scholar
Hetenyi, G. & Reynolds, J. (1967). A simplified procedure for counting doubly labelled quenched samples of liquid scintillation spectrometry. International Journal of Applied Radiation and Isotopes 18, 331–332.CrossRefGoogle Scholar
Jones, G. B. (1965). Determination of the specific activity of labelled blood glucose by liquid scintillation using glucose pentacetate. Analytical Biochemistry 12, 249–258.CrossRefGoogle Scholar
Lerner, L. J., Turkheimer, A. R., Bianchi, A., Singer, F. M. & Borman, A. (1964). Comparison of anti-granuloma, thymolytic and glucocorticoid activities of anti-inflammatory steroids. Proceedings of the Society of Experimental Biology and Medicine 116, 385–388.CrossRefGoogle ScholarPubMed
McClymont, G. L. & Setchell, B. P. (1955). Ovine pregnancy toxaemia. 1. Tentative identification as a hypoglycaemic encephalopathy. The Australian Veterinary Journal 31, 53–68.CrossRefGoogle Scholar
Morley, G., Dawson, A. & Marks, V. (1968). Manual and auto-analyzer methods for measuring blood glucose using guaiacum and glucose oxidase. Proceedings of the Association of Clinical Biochemistry 5, 42–45.CrossRefGoogle Scholar
Ranaweera, A. & Ford, E. J. H. (1976). The effect of two synthetic steroids on plasma glucose concentration and total entry rate of glucose in sheep. Journal of Agricultural Science, Cambridge 87, 417–421.CrossRefGoogle Scholar
Ranaweera, A., Ford, E. J. H. & Evans, J. (1981). Glucogenesis from glycerol by ketotic sheep pregnant with twins. Research in Veterinary Science 30, 303–308.CrossRefGoogle Scholar
Ranaweera, A., Ford, E. J. H. & Samad, A. R. (1979). The effect of triamcinolone acetonide on plasma glucose and ketone concentration and on the total entry rate of glucose in twin pregnant hypoglycaemic ketotic sheep. Research in Veterinary Science 26, 12–16.CrossRefGoogle ScholarPubMed
Reid, R. L. (1950). Studies on the carbohydrate metabolism of sheep. 1. The range of blood-sugar values under several conditions. Australian Journal of Agricultural Research 1, 182–199.CrossRefGoogle Scholar
Reilly, P. E. B. & Black, A. L. (1973). Early effects of cortisol on glucose and alanine metabolism in adrenalectomized sheep. American Journal of Physiology 225, 689–695.CrossRefGoogle ScholarPubMed
Williamson, J. R. & Krebs, H. A. (1961). Acetoacetate as fuel of respiration in the perfused rat heart. Biochemical Journal 80, 540–547.CrossRefGoogle ScholarPubMed