Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-03T05:00:38.332Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of alkaloid-free ergot on the growth of obese and lean mice

Published online by Cambridge University Press:  27 March 2009

P. G. Mantle  and
Julia Willingale
P. G. Mantle
Affiliation:
Biochemistry Department, Imperial College, London SW7
Julia Willingale
Affiliation:
Biochemistry Department, Imperial College, London SW7
Get access Rights & Permissions [Opens in a new window]

Summary

Young Lean And Obese Mice given diets containing, respectively, 5% reducing to 3% and 5% rising to 7% of typical alkaloid-containing ergot (Claviceps purpurea) showed inappetence, failed to grow during the period of 19 days and some individuals died. In contrast, ergot of a strain which cannot biosynthesize ergoline alkaloids was generally well accepted in dietary proportions, rising stepwise from 5 to 12% over the same period; growth rates of animals on control and alkaloid-free ergot diets did not differ significantly. The findings provide a context in which to discuss differentiation of ergoline alkaloids from the inappetence which is a prominent feature of ergot poisoning.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 105 , Issue 2 , October 1985 , pp. 407 - 411
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Berde, B. & Schild, H. O. (1978). Ergot alkaloids and related compounds. Handbook of Experimental Pharmacology, vol. 49. Berlin: Springer-Verlag.Google Scholar
Biggio, P., Gessa, G. L. & Pinetti, P. (1964). Azione protettiva esercitata dalla griseofulvina sulla necrosi ischemia da ergotamina della coda del ratto. Rassegna Medica Sarda 67, 55–62.Google Scholar
Corbett, K., Dickerson, A. G. & Mantle, P. G. (1974). Metabolic studies on Claviceps purpurea during parasitic development on rye. Journal of General Microbiology 84, 39–58.CrossRefGoogle ScholarPubMed
Cunningham, I. J., McIntosh, I. G. & Swan, J. B. (1944). The non-toxicity of milk and meat from ergotised cattle. New Zealand Journal of Science and Technology 26, 125–136.Google Scholar
Dinnusson, W. E., Haugse, C. N. & Knutson, R. D. (1971). Ergot in rations for fattening cattle. North Dakota Farm Research 29, 20–22.Google Scholar
Eastcott, A. (1972). Influence of restricting the diet on breeding of genetically obese mice. Laboratory Animals 6, 9–18.CrossRefGoogle ScholarPubMed
Greatorex, J. C. & Mantle, P. G. (1973). Experimental ergotism in sheep. Research in Veterinary Science 15, 337–346.CrossRefGoogle ScholarPubMed
Mantle, P. G. (1978). Ergotism in cattle, sheep and swine. In Mycotoxic Fungi, Mycotoxins, Mycotoxices, vol. 2 (ed. Wyllie, T. D. and Morehouse, L. G.). New York: Marcel Dekker.Google Scholar
Mantle, P. G., Shaw, S. & Doling, D. A. (1977). Role of weed grasses in the etiology of ergot disease in wheat. Annals of Applied Biology 86, 339–351.CrossRefGoogle Scholar
Skarland, A. S. & Thomas, O. O. (1972). Effect of ergot on performance of beef heifers. Proceedings of the Western Section of the American Society of Animal Science 23, 426–431.Google Scholar
Whittemore, C. T., Macer, R. C. F., Miller, J. K. & Mantle, P. G. (1976). Some consequences of the ingestion by young and growing pigs of feed contaminated ergot. Research in Veterinary Science 20, 61–69.CrossRefGoogle Scholar
Whittemore, C. T., Miller, J. K. & Mantle, P. G. (1977). Further studies concerning the toxicity of ingested ergot selerotia (Claviceps purpurea) to young and growing pigs. Research in Veterinary Science 22, 46–150.CrossRefGoogle Scholar
Wlllingale, J., Atwell, S. M. & Mantle, P. G. (1983). Unusual ergot alkaloid biosynthesis in selerotia of a Claviceps purpurea mutant. Journal of General Microbiology 129, 2109–2115.Google Scholar