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The relationship of circulating glucose, ketones, and F.F.A. to milk production in Awassi ewes

Published online by Cambridge University Press:  27 March 2009

J. H. Adler  and
E. Lotan
J. H. Adler
Affiliation:
Department of Physiology, Hebrew University—Hadassah Medical School, Jerusalem, Israel
E. Lotan
Affiliation:
Hahaklait Degania A.
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Extract

The relationship between milk production, blood glucose, blood ketones and free fatty acids (F.F.A.) were studied in lactating Awassi ewes. Increased milk production in ewes was associated with diminished blood glucose and increased serum F.F.A. Clinical cases of ketosis were not observed.

The ewes studied here could be divided into two metabolic populations depending on their blood ketone levels. Those with blood ketone levels of 11 mg % or more, did not show a significant increase in serum F.F.A. or a decrease in blood glucose values with increased milk production. The group of ewes with less than 11 mg % blood ketones showed a significant decrease in blood glucose and a significant increase in serum F.F.A. as milk production increased. Ketonemia of the high ketone group of ewes, was associated with relatively low serum F.F.A. levels. It is suggested that these ketones not originate from depot fat via serum F.F.A. These ketones and/or their precursors, acetic and butyric acids probably participate in caloric homeostasis and are associated with a glucose sparing serum F.F.A. suppressing mechanism.

The suggestion that ketones derived from rumen (R.D.K.) should be distinguished from those derived from adipose tissue (A.D.K.) is discussed.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 69 , Issue 3 , December 1967 , pp. 349 - 354
Copyright
Copyright © Cambridge University Press 1967

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References

Adler, J. H. & Dye, J. A. (1956). The mechanism of ketogenesis in ruminants. Cornell Vet. 46, 58—63.Google ScholarPubMed
Adler, J. H. & Wertheimer, E. (1962). A reciprocal relationship between blood glucose and plasma free fatty acids (FFA) in dairy cows and its significance for problems of fat metabolism in ruminants. Bull. Res. Coun. Israel 10E, 97–101.Google Scholar
Adler, J. H., Wertheimer, E., Bartana, U. & Flesh, J. (1963). Free fatty acids (FFA) and the origin of ketone bodies in cows. Vet. Rec. 75, 304–7.Google Scholar
Annison, E. F. (1960). Plasma non-esterified fatty acids in sheep. Aust. J. agric. Res. 11, 58–64.CrossRefGoogle Scholar
Annison, E. F., Hill, K. J. & Lewis, D. (1957). Absorption of volatile fatty acids from the rumen of the sheep. Biochem. J. 66, 592–9.CrossRefGoogle ScholarPubMed
Behre, J. A. & Benedict, S. R. (1926). A colorimetric method for the determination of acetone bodies in blood and urine. J. biol. Chem. 70, 487–94.CrossRefGoogle Scholar
Carlson, L. A., Boberg, J. & Högstedt, B. (1965). Some physiological and clinical implications of lipid mobilization from adipose tissue. Handbook of Physiology, 5, 625–44. American Physiological Society, Washington, D.C.Google Scholar
Dole, V. P. (1956). A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. din. Invest. 35, 150–4.Google ScholarPubMed
Dole, V. P. (1958). Fat metabolism in diabetes. Bull. N.Y. Acad. Med. 34, 21–5.Google ScholarPubMed
Finct, M. (1957). The Improvement of the Awassi breed of sheep in Israel. Jerusalem: Weizmann Sci. Press of Israel, pp. 72–86.Google Scholar
Gordon, R. S. & Cherkes, A. (1956). Unesterified fatty acid in human blood plasma. J. din. Invest. 35, 206–12.Google ScholarPubMed
Hestin-Lerner, S. & Ben-Yonah, Sh. (1963). Routine determination of blood glucose with glucose oxidase. Bull. Res. Coun. Israel 10 E.Google Scholar
Hirsoh, S. (1933). Sheep Rearing in Israel, p. 19. (Hebrew). Hapoel Hazair, Tel-Aviv.Google Scholar
Hodson, H. H., McGillaed, A. D., Jacobson, N. L. & Allen, R. S. (1965). Metabolic role of rumen mucosa in absorption of butyrate. J. Dairy Sci. 48, 1652–6.CrossRefGoogle Scholar
Keston, A. S. (1956). Specific colorimetric enzymatic analytical reagents for glucose. Meeting Am. chem. Soc. Abstr. 129, 31C.Google Scholar
Kronfield, D. S. (1965). Plasma non-esterified fatty acid concentrations in the dairy cow. Vet. Rec. 77, 30–5.Google Scholar
Patterson, D. S. P., Burns, K. N., Cunningham, N. F., Herert, N. C. & Saba, N. (1964). Plasma concentrations of glucose and non-esterified fatty acids (N.E.F.A.) in the pregnant and lactating ewe and the effect of dietary restriction. J. agric. Sci. Camb. 62, 253–61.CrossRefGoogle Scholar
Patterson, D. S. P. (1964). The effect of intravenous glucose on depot fat mobilization in the sheep. Res. vet. Sci. 5, 286–93.CrossRefGoogle Scholar
Pennington, R. J. (1952). Fatty acid utilization and ketone body production by rumen epithelium and other tissues. Biochem. J. 51, 251–8.CrossRefGoogle ScholarPubMed
Radloff, H. D., Schultz, L. H. & Hoekstra, W. G. (1966). Relationship of plasma free fatty acids to other blood components in ruminants under various physiological conditions. J. Dairy Sci. 48, 179–82.CrossRefGoogle Scholar
Reid, R. L. & Hinks, N. T. (1962 a). The metabolism of glucose, free fatty acids, ketones and amino acids in the late pregnancy and lactation. Aust. J. agric. Res. 13, 1112–23.CrossRefGoogle Scholar
Reid, R. L. & Hinks, N. T. (1962 b). The metabolism of glucose, free fatty acids, and ketones after feeding and during fasting or undernourishment of nonpregnant, pregnant and lactating ewes. Aust. J. agric. Res. 13, 1124–36.CrossRefGoogle Scholar
Roe, W. E., Bergman, E. N. & Kon, K. (1966). Absorption of ketone bodies and other metabolites via the portal blood of sheep. Am. J. vet. Res. 27, 729–36.Google ScholarPubMed
Udall, D. H. (1947). The Practice of Veterinary Medicine, 5th ed., p. 365, Published by author, New YorkGoogle Scholar