Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-03T04:59:08.716Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of lα-hydroxycholecalciferol on calcium and phosphorus metabolism in sheep given high or low calcium diets

Published online by Cambridge University Press:  27 March 2009

G. D. Braithwaite
G. D. Braithwaite
Affiliation:
National Institute for Research in Dairying, Shinfield, Reading, RG2 9AT
Get access Rights & Permissions [Opens in a new window]

Summary

The relationship between calcium and phosphorus metabolism in wether sheep given high or low Ca diets, with or without 1α-hydroxycholecalciferol (1α-0H-D3) has been studied by a mineral balance and radioactive technique.

Ca absorption was not related to Ca intake but was stimulated by 1α-OH-D3. More Ca was absorbed by treated animals from the high Ca diet than from the low diet and all the extra Ca absorbed was retained, increased retention being brought about largely by an increase in the rate of bone accretion.

P absorption was increased to approximately the same extent from both diets suggesting that stimulation was due to the 1 α-0H-D3 treatment rather than increased Ca absorption. Whereas the extra P absorbed from the high Ca diet was retained, together with Ca, in bone and soft tissues, that absorbed from the low Ca diet was largely excreted in the urine. It is suggested that this difference in P retention reflects a difference in availability of Ca for retention in bone and P retention was in fact found to be directly related to Ca retention.

The roles of secretion of P into the gut, absorption of P from the gut and urinary excretion of P are discussed in relation to P homoeostasis.

As absorption of P from the intestine and loss of P to bone, soft tissues and urine increased, so endogenous faecal loss decreased until it reached a value of approximately 35 mg/day per kg body weight when it remained constant. It is suggested that this value may represent the inevitable loss of endogenous P in the faeces from a hay and concentrates diet and that this minimum value may have a bearing on the calculation of P requirements.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 96 , Issue 2 , April 1981 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Agricultural Research Council (1965). The Nutrient Requirements of Farm Livestock. No. 2, Ruminants. London: H.M. Stationery Office.Google Scholar
Aubert, J.-P. & Milhaud, G. (1960). Méhode de mosure des principles voies du méabolisme calcique chez l'homme. Biochimica et Biophysica Acta 39, 122–139.CrossRefGoogle Scholar
Barlet, J.-P. (1977). Prophylaxie et théapeutique de l'hypocalcéie vitulaire par les isomées ou les méabolites de la vitamine D. 11 Le 1α-hydroxycholéalciféol. Annales de Biologie Animate, Biochimie, Biophysique 17, 363–371.CrossRefGoogle Scholar
Braithwaite, G. D. (1974). The effect of changes of dietary calcium concentration on calcium metabolism in sheep. British Journal of Nutrition 31, 319–331.CrossRefGoogle ScholarPubMed
Braithwaite, G. D. (1976). Reviews of the progress of Dairy Science. Calcium and phosphorus metabolism in ruminants with special reference to parturient paresis. Journal of Dairy Research 43, 501–520.CrossRefGoogle Scholar
Braithwaite, G. D. (1978). The effect of 1 α-hydroxyoholecalciferol on calcium and phosphorus metabolism in the lactating ewe. British Journal of Nutrition 40, 387–392.CrossRefGoogle ScholarPubMed
Braithwaite, G. D. (1979 a). The effect of dietary intake of calcium and phosphorus on their absorption and retention by mature Ca-replete sheep. Journal of Agricultural Science, Cambridge 92, 337–342.CrossRefGoogle Scholar
Braithwaite, G. D. (1979 b). Calcium and phosphorus metabolism in sheep. Annales de Recherches Vétérinaires 10, 359–361.Google ScholarPubMed
Braithwaite, G. D. (1980). The effect of dose rate of 1α-hydroxycholecalciferol on calcium and phosphorus metabolism in sheep. British Journal of Nutrition 44, 183–191.CrossRefGoogle Scholar
Braithwaite, G. D. & Glascock, R. F. (1976). Metabolism of calcium in the sheep. Biennial Reviews. National Institute for Research in Dairying, pp. 43–59.Google Scholar
Braithwaite, G. D., Glascock, R. F. & Riazuddin, Sh. (1969). Calcium metabolism in lactating ewes. British Journal of Nutrition 23, 827–834.CrossRefGoogle ScholarPubMed
Braithwaite, G. D., Glascock, R. F. & Riazuddin, Sh. (1970). Calcium metabolism in pregnant ewes. British Journal of Nutrition 24, 661–670.CrossRefGoogle ScholarPubMed
Braithwaite, G. D. & Riazuddin, Sh. (1971). The effect of age and level of dietary calcium intake on calcium metabolism in sheep. British Journal of Nutrition 26, 215–225.CrossRefGoogle ScholarPubMed
Chen, T. C., Castillo, L., Korycka-Dahl, M. & Deluca, H. F. (1974). Role of vitamin D metabolites in phosphate transport. Journal of Nutrition 98, 1056–1060.CrossRefGoogle Scholar
Fiske, C. H. & Subbarow, Y. (1925). The colorimetric determination of phosphorus. Journal of Biological Chemistry 66, 375–400.CrossRefGoogle Scholar
Fox, J. & Care, A. D. (1976). The effects of hydroxylated derivatives of vitamin D3 and of extracts of Solanum malacoxylon on the absorption of calcium, phosphate and water from the jejunum of pigs. In Calcified Tissues ‘1975’ (ed. Nielson, S. Pors and Hjorting-Hanson, E.), pp. 147–152. Copenhagen: FADL Publishing Co.Google ScholarPubMed
Gast, D. R., Marquardt, J. P., Jorgensen, N. A. & Deluca, H. F. (1977). Efficacy and safety of 1α-hydroxyvitamin D3 for prevention of parturient paresis. Journal of Dairy Science 60, 1910—1920.CrossRefGoogle ScholarPubMed
Harrison, H. E. & Harrison, H. C. (1961). Intestinal transport of phosphate: action of vitamin D, calcium and phosphorus. American Journal of Physiology 201, 1007–1012.CrossRefGoogle Scholar
Holick, M. F., Taleva, T. E., Holick, S. A., Schnoes, H. K., Deluca, H. F. & Gallagher, B. M. (1976). Synthesis of 1α-hydroxy[6-3H]-vitamin D3 and its metabolism to 1α,25-dihydroxy[6-3H]-vitamin D3 in the rat. Journal of Biological Chemistry 251, 1020–1024.CrossRefGoogle Scholar
Lueker, C. E. & Lofgreen, G. P. (1961). Effects of intake and calcium to phosphorus ratio on absorption of these elements by sheep. Journal of Nutrition 74, 233–238.CrossRefGoogle Scholar
Manston, R. (1966). The effects of large doses of vitamin A on calcium and phosphorus metabolism in the cow. British Veterinary Journal 122, 443–449.CrossRefGoogle Scholar
Manston, R. & Vagg, M. J. (1970). Urinary phosphate excretion in the dairy cow. Journal of Agricultural Science, Cambridge 74, 161–167.CrossRefGoogle Scholar
Meyer, H. (1972). An anomaly in renal phosphorus excretion in sheep. Deutsche Tierärztliche Wochenschrift 79, 426–427.Google ScholarPubMed
National Research Council (1968). Nutrient Requirements of Domestic Animals. No. 5, Nutrient Requirements of Sheep. Publication 1693, National Academy of Sciences, Washington, D.C.Google Scholar
Norman, A. W. (1978). Calcium and phosporus absorption. In Vitamin D (ed. Lawson, D. E. M.), pp. 93–132. New York and London: Academic Press.Google ScholarPubMed
Parsons, D. H. (1968). Calculation of the parameters of calcium metabolism. Mathematical Biosciences 2, 191–197.CrossRefGoogle Scholar
Preston, R. L. & Pfander, W. H. (1964). Phosphorus metabolism in lambs fed varying phosphorus intakes. Journal of Nutrition 83, 369–378.CrossRefGoogle ScholarPubMed
Sachs, M., Bar, A., Cohen, R., Mazur, Y., Mayer, E.Hurwitz, S. (1977). Use of 1α-hydroxycholecalciferol in the prevention of bovine parturient paresis. The American Journal of Veterinary Research 38, 2039–2041.Google ScholarPubMed
Sansom, B. F., Allen, W. M., Davies, D. C., Hoare, M. H., Stenton, J. R. & Vagg, M. J. (1976). Use of 1α-OH cholecalciferol in preventing post parturient hypooalcaemia and its potential value for prevention of milk fever in dairy cows. The Veterinary Record 99, 310–312.CrossRefGoogle ScholarPubMed
Sykes, A. R. & Dingwall, R. A. (1976). The phosphorus requirement of pregnant sheep. Journal of Agricultural Science, Cambridge 86, 587–594.CrossRefGoogle Scholar
Technicon Instruments Corporation (1967). Inorganic phosphate. Technicon Methods Sheet, N-4B. Tarry Town, New York: Technicon Instruments Corporation.Google Scholar
Tomas, F. M. & Somers, M. (1974). Phosphorus homeostasis in sheep. I. Effect of ligation of parotid salivary ducts. Australian Journal of Agricultural Research 25, 475–483.CrossRefGoogle Scholar
Towns, K. M., Boston, R. C. & Leaver, D. D. (1978). The effect of intravenous administration of phosphorus on phosphorus and calcium metabolism in sheep. Australian Journal of Agricultural Research 29, 587–593.CrossRefGoogle Scholar
Wasserman, R. H. (1975). Metabolism, function and clinical aspects of vitamin D. The Cornell Veterinarian 65, 3–25.Google ScholarPubMed
Wasserman, R. H. & Taylor, A. N. (1973). Intestinal absorption of phosphate in the chick: effect of vitamin Ds and other parameters. Journal of Nutrition 103, 586–599.CrossRefGoogle Scholar
Young, V. R., Lofgreen, G. P. & Luick, J. R. (1966). The effects of phosphorus depletion, and of calcium and phosphorus intake, on the endogenous excretion of these elements by sheep. British Journal of Nutrition 20, 795–805.CrossRefGoogle ScholarPubMed
Young, V. R., Richards, W. P. C., Lofgreen, G. P. & Luick, J. R. (1966). Phosphorus depletion in sheep and the ratio of calcium to phosphorus in the diet with reference to calcium and phosphorus absorption. British Journal of Nutrition 20, 783–794.CrossRefGoogle ScholarPubMed