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Effect of alkaloid-free ergot on the growth of obese and lean mice

Published online by Cambridge University Press:  27 March 2009

P. G. Mantle  and
Julia Willingale
P. G. Mantle
Affiliation:
Biochemistry Department, Imperial College, London SW7
Julia Willingale
Affiliation:
Biochemistry Department, Imperial College, London SW7
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Summary

Young Lean And Obese Mice given diets containing, respectively, 5% reducing to 3% and 5% rising to 7% of typical alkaloid-containing ergot (Claviceps purpurea) showed inappetence, failed to grow during the period of 19 days and some individuals died. In contrast, ergot of a strain which cannot biosynthesize ergoline alkaloids was generally well accepted in dietary proportions, rising stepwise from 5 to 12% over the same period; growth rates of animals on control and alkaloid-free ergot diets did not differ significantly. The findings provide a context in which to discuss differentiation of ergoline alkaloids from the inappetence which is a prominent feature of ergot poisoning.

Type
Research Article
Information
The Journal of Agricultural Science , Volume 105 , Issue 2 , October 1985 , pp. 407 - 411
Copyright
Copyright © Cambridge University Press 1985

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References

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