Food is essential for human survival. When the right quantity and quality is taken, it ensures growth and an adequate supply of nutrition to the body, which results in basic effectiveness in all spheres of life. Genetically modified crops have the potential to alleviate hunger and provide more food, especially in developing countries that have high levels of hunger, malnutrition and poverty. Although the debates on genetically modified crops generally focus on intellectual property, other issues include health and environmental concerns. This article examines these issues with the aim of providing holistic knowledge of the subject matter, which is important for stakeholders, particularly in developing countries, in deciding to protect plant variety rights. The article concludes that it is essential for developing countries to consider food security issues in fulfilling their obligations under the TRIPS Agreement.