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Toxic psychosis? Duration of untreated psychosis, symptomatology and cognitive deterioration in first episode psychosis

Published online by Cambridge University Press:  13 June 2014

Richard Lawoyin ,
Keith Gaynor ,
Barbara Dooley ,
Elizabeth Lawlor ,
Mary Clarke  and
Eadbhard O'Callaghan
Richard Lawoyin
Affiliation:
Cluain Mhuire Service, Blackrock, Co Dublin, Ireland
Keith Gaynor*
Affiliation:
Cluain Mhuire Service, Blackrock, Co Dublin University College Dublin, School of Psychology, Dublin 4, Ireland
Barbara Dooley
Affiliation:
University College Dublin, School of Psychology, Dublin 4, Ireland
Elizabeth Lawlor
Affiliation:
Cluain Mhuire Service, Blackrock, Co Dublin and DELTA/DETECT, Early Psychosis Intervention Project, Dun Laoghaire, Ireland
Mary Clarke
Affiliation:
St John of God Hospital, Stillorgan, Co Dublin, Ireland
Eadbhard O'Callaghan
Affiliation:
St John of God Hospital, Stillorgan, Co Dublin DELTA/DETECT, Early Psychosis Intervention Project, Dun Laoghaire and University College Dublin, School of Medicine, Dublin 4, Ireland
*
Correspondence Email: [email protected]
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Abstract

Objectives: To examine the relationship between cognitive deficits, the duration of untreated psychosis (DUP) and positive and negative symptoms in a first episode psychosis sample.

Method: We assessed a consecutive sample of first episode psychosis participants from a catchment area service with a comprehensive neuropsychology battery, a family and service-user based measure of DUP and measures of symptomatology.

Results: Using correlations and stepwise linear regressions, we found strong relationships between measures of DUP and positive symptomatology. We found that positive and negative symptoms were associated with different time periods within DUP. However, we did not find evidence of a relationship between DUP and cognitive factors.

Conclusions: There was no evidence of a relationship between DUP and cognitive deterioration. However, there does appear to be evidence of a relationship between positive symptoms and aspects of DUP. These results highlight the importance of the heterogeneity of DUP and the potential to reduce positive symptoms through early intervention.

Keywords

PsychosisSchizophreniaDuration of untreated psychosisDUPCognitive functioning.
Type
Brief Report
Information
Irish Journal of Psychological Medicine , Volume 24 , Issue 4 , December 2007 , pp. 145 - 148
Copyright
Copyright © Cambridge University Press 2007

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