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Recent developments in the genetics of schizophrenia

Published online by Cambridge University Press:  13 June 2014

Kieran C Murphy  and
Michael Gill
Kieran C Murphy
Affiliation:
Department of Psychological Medicine and Medical Genetics, University of Wales, College of Medicine, Heath Park, Cardiff CF4 4XN, Wales
Michael Gill
Affiliation:
Department of Psychiatry, Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Ireland
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Abstract

Objectives: To examine the evidence concerning the recent developments in the genetics of schizophrenia.

Methods: An extensive literature search was performed and relevant papers were examined and analysed.

Findings: There is overwhelming evidence that schizophrenia shows familial aggregation. Recent molecular genetic studies support the presence of susceptibility genes on chromosomes 6 and 22. In addition, an association between schizophrenia, the dopamine D3 receptor gene and the 5-HT2a receptor gene has also been demonstrated.

Conclusions: Recent advances in DNA technology have paved the way for the detection of genes of major and minor effects in the aetiology of schizophrenia. If the presence of the recently identified susceptibility genes is confirmed, it is likely that these genes will be recognised in the near future.

Keywords

SchizophreniaMolecular geneticsChromosome 6Chromosome 22D3 receptor5-HT2a receptor
Type
Reviews
Information
Irish Journal of Psychological Medicine , Volume 13 , Issue 4 , December 1996 , pp. 151 - 154
Copyright
Copyright © Cambridge University Press 1996

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