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RE: Hypertension and increased serum clozapine associated with clozapine and fluoxetine in combination

Published online by Cambridge University Press:  13 June 2014

Siow-Ann Chong
Affiliation:
Fellow
Gary Remington
Affiliation:
Schizophrenia Division, Clarke Institute of Psychiatry, Toronto, Ontario, Canada
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Abstract

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Type
Letter to the Editor
Copyright
Copyright © Cambridge University Press 1998

References

1.Sloan, D, O'Boyle, J. Hypertension and increased serum clozapine associated with clozapine and fluoxetine in combination. Ir J Psych Med 1997; 14:151–2.CrossRefGoogle Scholar
2.Fisher, V, Vogels, B, Maurer, G, Tynes, R. The antipsychotic clozapine is metabolised by the polymorphic human microsomal and recombinant cytochrome P450 2D6. J Pharmacol Exp Ther 1992; 260: 1355–60.Google Scholar
3.Dahl, M, Llerena, A, Bondesson, Uet al.Disposition of clozapine in man: lack of association with debrisoquine and S-mephenytoin hydroxylation polymorphism. Br J Clin Pharmacol 1994; 37: 71–4.CrossRefGoogle Scholar
4.De, Leon J, Wedlund, P, Ehlers, Ret al.Cytochrome P450 2D6 (CYP2D6) genotype: relationship with clozapine and haloperidol metabolism. Biol Psychiatry 1996; 39: 591.Google Scholar
5.Glue, P, Banfield, C. Psychiatry, psychopharmacology and P-450s. Human Psychopharmacology 1996; 11: 97114.3.0.CO;2-7>CrossRefGoogle Scholar