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Pharmacogenetics of the hepatic cytochrome P450 enzyme system: its relevance for prescribing in psychiatry

Published online by Cambridge University Press:  13 June 2014

Alan O'Donohoe  and
Michael Gill
Alan O'Donohoe
Affiliation:
Department of Psychiatry, St. James's Hospital, James's St, Dublin 8, Ireland
Michael Gill
Affiliation:
Department of Psychiatry, St. James's Hospital, James's St, Dublin 8, Ireland
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Abstract

This article reviews the current knowledge regarding the hepatic cytochrome P450 system, with particular reference to its effect on psychotherapeutic medication. The metabolic processes – by which drugs are broken down in the liver by cytochrome P450 enzymes – are affected by genetic variation between individuals, inhibition and induction of these enzymes by other drugs, disease and age. Genetic influences and enzyme inhibition/induction are discussed in particular detail in this article.

Keywords

Cytochrome P450PharmacogeneticsPsychopharmacologyGenotypeEnzyme inhibition
Type
Review
Information
Irish Journal of Psychological Medicine , Volume 15 , Issue 3 , September 1998 , pp. 96 - 99
Copyright
Copyright © Cambridge University Press 1998

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