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Brain blood flow abnormalities associated with oral cocaine use

Published online by Cambridge University Press:  13 June 2014

Bankole Johnson ,
Lamk Lamki ,
Bruce Barron ,
Ralph Spiga ,
Richard Chen ,
Richard Meisch  and
Neera Khilnani
Bankole Johnson
Affiliation:
Clinical Laboratory and Experimental Alcohol Research
Lamk Lamki
Affiliation:
Prof Dept of Nuclear Medicine
Neera Khilnani
Affiliation:
University of Texas, Health Science Center at Houston, Mental Sciences Institute, 1300 Moursund, Houston, Texas 77030, USA
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Abstract

Single photon emission tomography (SPECT) is the prototypical tool for measuring cerebral blood flow (CBF) in discrete areas of the brain. Compared with when a male ‘crack’ cocaine user received placebo, oral cocaine (1mg/kg) ingestion was associated with non-uniformity of overall CBF with hypoperfusion of discrete brain regions, particularly of the frontal, temporo-parietal, basal ganglia, and thalamic areas. While these results should be viewed as preliminary, they do suggest that oral cocaine use may be associated with CBF abnormalities in ‘crack’ users.

Keywords

SPECTTc-HMPAONeuroimagingOral cocaineCerebral blood flowBrain
Type
Case Reports
Information
Irish Journal of Psychological Medicine , Volume 14 , Issue 2 , June 1997 , pp. 72 - 73
Copyright
Copyright © Cambridge University Press 1997

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References

1.Tumeh, SS, Nagel, JS, English, RJ, Moore, M, Holman, BL. Cerebral abnormalities in cocaine abusers: demonstration by SPECT perfusion brain scintigraphy. Radiology 1990; 176: 821–4.CrossRefGoogle ScholarPubMed
2.London, ED. The effects of drug abuse on glucose metabolism. J Neuropsychiatry Clin Neurosci 1989; 1: S30–S6.Google ScholarPubMed
3.London, ED, Broussolle, EP, JM, Linkset al.Morphine induced metabolic changes in human brain. Arch Gen Psychiatry 1990a; 47: 73–81.CrossRefGoogle ScholarPubMed
4.London, ED, NG, Cascella, DF, Wonget al.Cocaine-induced reduction of glucose utilisation in the human brain. Arch Gen Psychiatry 1990b; 47: 567–74.CrossRefGoogle Scholar
5.Holman, BL, Carvalho, PA, Mendelson, Jet al.Brain perfusion is abnormal in cocaine-dependent polydrug users: a study using technetium-99m-HMPAO and SPECT. J Nucl Med 1991; 32: 1206–10.Google Scholar
6.Woods, SW, O'Malley, SS, BL, Martiniet al.SPECT regional cerebral blood flow and neuropsychological testing in nondemented HIV-positive drug abusers: preliminary results. Prog Neuropsychopharmacol Biol Psychiatry 1991; 15: 649–62.CrossRefGoogle ScholarPubMed
7.Woods, SW. Regional cerebral blood flow imaging with SPECT in psychiatric disease: focus on schizophrenia, anxiety disorders, and substance abuse. J Clin Psychiatry 1992; 53: S20–S5.Google ScholarPubMed
8.Lamki, LM, Tran, HD, Barron, BJ. Pitfalls and artifacts in high resolution Tc-99m-Exametazime brain SPECT imaging and some solutions. Clin Nucl Med 1993; 18:174.CrossRefGoogle Scholar
9.Jensen, R, Olsen, TS, Wintrier, BB. Severe non-occlusive ischemic stroke in young heroin addicts. Acta Neurol Scand 1990; 81: 354–7.CrossRefGoogle ScholarPubMed
10.Holman, BL, Garada, B, KA, Johnsonet al.A comparison of Brain perfusion SPECT in cocaine abuse and AIDS dementia complex. J Nucl Med 1992; 33: 1312–5.Google ScholarPubMed
11.Volkow, ND, Fowler, JS, Wang, GJ, Hitzemann, R, Logan, J, Schlyer, DJ, SL, Dewey, AP, Wolf. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 1993; 15: 246–9.Google Scholar
12.Isner, JM, Chokshi, SK. Cocaine and vasospasm. N Engl J Med 1989; 321: 1604–6.CrossRefGoogle ScholarPubMed
13.Neirinckx, RD, Burke, JF, Harrison, RC, Forster, AM, Andersen, AR, NA, Lassen. The retention mechanism of Tc-99m HMPAO: intra cellular reaction with glutathione. J Cereb Blood Flow and Metab 1988; 8: 4–12.CrossRefGoogle Scholar