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Adinazolam sustained release formulation in the treatment of panic disorder: a pilot study

Published online by Cambridge University Press:  13 June 2014

David V. Sheehan ,
Ashok B Raj ,
K. Harnett-Sheehan ,
Sonia Soto  and
Carl P. Lewis
David V. Sheehan
Affiliation:
Professor of Psychiatry and Director of Research, Department of Psychiatry and Behavioural Medicine, University of South Florida College of Medicine, Tampa, Florida.
Ashok B Raj
Affiliation:
Associate Professor Psychiatry, Department of Psychiatry and Behavioural Medicine, University of South Florida College of Medicine, Tampa, Florida.
K. Harnett-Sheehan
Affiliation:
Assistant Professor of Psychiatry, Department of Psychiatry and Behavioural Medicine, University of South Florida College of Medicine, Tampa, Florida.
Sonia Soto
Affiliation:
Instructor of Psychiatry and Behavioural Medicine, University of South Florida College of Medicine, Tampa, Florida.
Carl P. Lewis
Affiliation:
Clinical Development, The Upjohn Company, Kalamazoo, Michigan.
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Abstract

This is the first report on the use of the sustained release formulation of adinazolam in the treatment of panic disorder. A six week open lable trial followed by a 1-6 week taper/discontinuation phase was used to assess the safety and efficacy of adinazolam (Deracyn-SR) in the treatment of 10 outpatients with panic disorder and agoraphobia. Adinazolam-SR was well tolerated and produced a rapid improvement in panic and limited symptom attacks, anxiety, phobias, disability, and depressive symptoms. Mean ±S.D. duration of therapeutic action of each dose of this formulation was 12.2±2.3 hours. This is longer than the duration of therapeutic action of other benzodiazepine formulations studied to date for the treatment of panic disorder. Frequency of relapse, rebound and withdrawal symptoms was similar to that found on taper/discontinuation from alprazolam.

Keywords

AdinazolamPanic DisorderAgoraphobiaPanic AttacksAnxietyDuration of Action.
Type
Original Papers
Information
Irish Journal of Psychological Medicine , Volume 7 , Issue 2 , September 1990 , pp. 124 - 128
Copyright
Copyright © Cambridge University Press 1990

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