Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-25T05:37:12.307Z Has data issue: false hasContentIssue false
  • English
  • Français

Treating behavioral and psychological symptoms in patients with psychosis of Alzheimer's disease using risperidone

Published online by Cambridge University Press:  31 July 2006

Jonathan Rabinowitz ,
Ira Katz ,
Peter Paul De Deyn ,
Andrew Greenspan  and
Henry Brodaty
Jonathan Rabinowitz
Affiliation:
Bar Ilan University, Ramat Gan, Israel
Ira Katz
Affiliation:
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Peter Paul De Deyn
Affiliation:
Department of Neurology, Memory Clinic, Middelheim Hospital, ZNA, and Laboratory of Neurochemistry and Behavior, Born Bunge Institute, Biomedical Sciences, University of Antwerp, Wilrijk-Antwerp, Belgium
Andrew Greenspan
Affiliation:
Johnson & Johnson Pharmaceutical Research & Development, Titusville, NJ, USA
Henry Brodaty
Affiliation:
Academic Department for Old Age Psychiatry, University of New South Wales, Euroa Centre, Prince of Wales Hospital, Sydney, Australia
Get access

Abstract

Objectives: To examine the effect of risperidone on specific behavioral and psychological symptoms of dementia (BPSD) among patients with psychosis of Alzheimer's disease (AD).

Methods: Post hoc exploratory analysis of data on 479 nursing-home patients with psychosis of AD from three 12-week, double-blind, placebo-controlled clinical trials. Criteria for psychosis of AD were a diagnosis of AD or mixed dementia and a rating of ≥ 2 on any delusion or hallucination item of the Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) rating scale when entering the trial. Mean changes from baseline to endpoint were examined for items on the Cohen-Mansfield Agitation Inventory (CMAI) and BEHAVE- AD.

Results: On the CMAI, risperidone was significantly more effective than placebo in treating cursing or verbal aggression (p = 0.004), hitting (p < 0.001), performing repetitious mannerisms (p < 0.001), pacing, aimless wandering (p = 0.017), hoarding things (p = 0.02), hiding things (p = 0.02) and repetitive sentences or questions (p = 0.025). On the BEHAVE-AD, risperidone was significantly more effective than placebo in treating physical threats and/or violence (p = 0.001), agitation (other) (p = 0.001) and verbal outbursts (p = 0.026). Although analysis on individual hallucination and delusional items did not demonstrate specific responses, analyses of a composite of delusional items revealed significant drug-placebo differences.

Conclusions: These data indicate that risperidone is effective in treating a variety of symptoms associated with psychosis of AD.

Keywords

BPSDdementiaatypical antipsychoticsnursing homes
Type
Research Article
Information
International Psychogeriatrics , Volume 19 , Issue 2 , April 2007 , pp. 227 - 240
Copyright
International Psychogeriatric Association 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)