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Sporadic Creutzfeldt-Jakob disease: a description of two cases

Published online by Cambridge University Press:  21 March 2012

Kavita Das ,
Rebecca Davis ,
Brett DuToit  and
Brian Parsons
Kavita Das*
Affiliation:
Department of Old Age Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, Surrey, UK Department of Psychological Medicine, Institute of Psychiatry, London, UK
Rebecca Davis
Affiliation:
Department of Old Age Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, Surrey, UK
Brett DuToit
Affiliation:
Department of Old Age Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, Surrey, UK
Brian Parsons
Affiliation:
Department of Old Age Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, Leatherhead, Surrey, UK
*
Correspondence should be addressed to: Kavita Das, Department of Old Age Psychiatry, Surrey and Borders Partnership NHS Foundation Trust, UK. Phone: + 44-01932-722467; Fax: + 44-01932-875128. Email: [email protected].
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Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare and devastating illness. It is the most frequently encountered form of the spongiform encephalopathies with 50 new cases a year in the UK. It presents with a myriad of symptoms reflecting central nervous system dysfunction and is characterized by a rapidly progressive dementia leading to death. The disease process can pose multiple challenges: diagnostic conundrums, complexities in management, and palliative care issues. Good coordinated care between services and information is paramount in adequate management and delivery of care for patients suffering from sCJD.

Psychiatry services frequently become involved in the assessment and management of sCJD.

Keywords

CJDsporadic CJDdementiaBPSDpalliative care
Type
Case Report
Information
International Psychogeriatrics , Volume 24 , Issue 7 , July 2012 , pp. 1183 - 1185
Copyright
Copyright © International Psychogeriatric Association 2012

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References

Aksamit, A. J., Preissner, C. and Homburger, H. (2001). Quantitation of 14-3-3 and neuron-specific enolase proteins in CSF in Creutzfeltd-Jakob disease. Neurology, 57, 728–730.CrossRefGoogle Scholar
Butler, R. and Fleminger, S. (2001). Creutzfeldt-Jakob disease and its implication for psychiatric management. Advances in Psychiatric Treatment, 7, 50–56.CrossRefGoogle Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). “Mini-mental state:” a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.Google Scholar
Henry, E. et al. (2002). Creutzfeldt-Jakob disease in elderly people. Age and Ageing, 31, 7–10.CrossRefGoogle ScholarPubMed
Lemstra, A. W. et al. (2000). 14-3-3 testing in diagnosing Creutzfeldt-Jakob disease. Neurology, 55, 514–516.CrossRefGoogle ScholarPubMed
Mioshi, E. et al. (2006). The Addenbooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. International Journal of Geriatric Psychiatry, 21, 1078–1085.CrossRefGoogle Scholar
Rosenbloom, M. H. and Atri, A. (2011). The evaluation of rapidly progressive dementia. Neurologist, 17, 67–74.CrossRefGoogle ScholarPubMed
Wall, A. C. et al. (2005). Psychiatric manifestations of Creutzfeldt-Jakob disease: a 25-year analysis. Journal of Neuropsychiatry and Clinical Neurosciences, 17, 489–495.CrossRefGoogle ScholarPubMed
Young, G. S. et al. (2005). Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis. Amerian Journal of Neuroradiology, 26, 1551–1562.Google ScholarPubMed