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Spatial navigation measured by the Floor Maze Test in patients with subjective cognitive impairment, mild cognitive impairment, and mild Alzheimer's disease

Published online by Cambridge University Press:  03 February 2015

Gro Gujord Tangen ,
Knut Engedal ,
Astrid Bergland ,
Tron Anders Moger ,
Oskar Hansson  and
Anne Marit Mengshoel
Gro Gujord Tangen*
Affiliation:
Department of Health Sciences, University of Oslo, Norway
Knut Engedal
Affiliation:
Norwegian Centre for Ageing and Health, Vestfold Health Trust, Tønsberg, Norway
Astrid Bergland
Affiliation:
Oslo and Akershus University College of Applied Sciences, Oslo, Norway
Tron Anders Moger
Affiliation:
Department of Health Management and Health Economics, University of Oslo, Oslo, Norway
Oskar Hansson
Affiliation:
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden Memory Clinic, Skåne University Hospital, Lund and Malmö, Sweden
Anne Marit Mengshoel
Affiliation:
Department of Health Sciences, University of Oslo, Norway
*
Correspondence should be addressed to: Gro Gujord Tangen, Department of Health Sciences, University of Oslo, P.O. Box 1089 Blindern, 0317 Oslo, Norway. Phone: +00 47 22 84 53 71; Fax: +00 47 22 84 50 91. Email: [email protected].
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Abstract

Background:

Impaired spatial navigation is an early sign of Alzheimer's disease (AD), but this can be difficult to assess in clinical practice. We examined how the performance on the Floor Maze Test (FMT), which combines navigation with walking, differed between patients with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and mild AD. We also explored if there was a significant relationship between the FMT and the cognitive tests or sociodemographic factors.

Methods:

The study included 128 patients from a memory clinic classified as having SCI (n = 19), MCI (n = 20), and mild AD (n = 89). Spatial navigation was assessed by having the patients walk through the FMT, a two-dimensional maze. Both timed measures and number of errors were recorded. Cognitive function was assessed by the Word List Memory test, the Clock Drawing test, the Trail Making tests (TMT) A and B, and the Mini Mental Status Examination (MMSE).

Results:

The patients with MCI were slower than those with SCI, while the patients with mild AD more frequently completed the FMT with errors or gave up than the patients with MCI. Performance on the FMT was significantly associated with executive function (measured by TMT-B).

Conclusions:

The performances on the FMT worsened with increasing severity of cognitive impairment, and the FMT was primarily associated with executive function. The explained variance was relatively low, which may indicate that the standard cognitive test battery does not capture impairments of spatial navigation.

Keywords

spatial navigationcognitionAlzheimermild cognitive impairmentsubjective cognitive impairment
Type
Research Article
Information
International Psychogeriatrics , Volume 27 , Issue 8 , August 2015 , pp. 1401 - 1409
Copyright
Copyright © International Psychogeriatric Association 2015 

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